Altered exercise ventilatory responses by apparent propranolol-diminished glucose metabolism: Implications concerning impaired physical training benefit in coronary patients

Hossack, Kenneth F.; Bruce, Robert A.; Kusumi, Fusako

doi:10.1016/0002-8703(81)90313-6

Cited by 14 publications

(3 citation statements)

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“…Bruce et al, 1979;Hossack et al, 1981;Sklar et al, 1982;Sable et al, 1982and more recently Petersen et al, 1983and Wilmore et al, 1983, observed no change, or a slight decrease in V02 max in normal subjects after acute injection or oral administration of a beta blocker.…”

Section: Discussionmentioning

confidence: 94%

“…A number of authors, Wasserman et al, 1973;Wasserman and Whipp, 1975;Davis et al, 1979;Matsumura et al, 1983, have defined anaerobic threshold as the level of work or oxygen consumption just below the point at which metabolic acidosis and other associated changes in S. N. Koyal M. H. El/estad gas exchange take place. Hossack et al, 1981, in their studies on propanolol on exercise training "prescription" demonstrated a minor but insignificant change in the ratio of maximal oxygen uptake to maximum heart rate. Contrary to Hossack et al, 1981;Obma et al, 1979;Thadani and Parker, 1979;Pratt et al, 1981;Vanhees et al, 1982;and recently Gordon et al, 1983, showed an improved cardiovascular and ventilatory responses after training in patients with coronary heart disease during beta-adrenergic blockade.…”

Section: Introductionmentioning

confidence: 99%

“…Hossack et al, 1981, in their studies on propanolol on exercise training "prescription" demonstrated a minor but insignificant change in the ratio of maximal oxygen uptake to maximum heart rate. Contrary to Hossack et al, 1981;Obma et al, 1979;Thadani and Parker, 1979;Pratt et al, 1981;Vanhees et al, 1982;and recently Gordon et al, 1983, showed an improved cardiovascular and ventilatory responses after training in patients with coronary heart disease during beta-adrenergic blockade. Table I represents the mean values with the standard deviation of physical characteristics and responses to maximal treadmill test before and after training in patients with coronary artery disease (CAD).S The data demonstrate a significant increase in V02 max, m4ximum 02 pulse, absolute treadmill time (duration) and reduction in maximum heart rate before and after training of 12-16 weeks.…”

Section: Introductionmentioning

confidence: 99%

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Does exercise alter anaerobic threshold in coronary artery disease during beta blockade?

Koyal¹,

Stuart²,

Lundstrom³

et al. 1985

Br J Sports Med

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The effect of propanolol on cardiac patients undergoing exercise training is reported to increase exercise tolerance and maximum oxygen uptake (O2 max) but its effect on anaerobic threshold (AT) is unknown. It was the purpose of this study to determine the role of exercise training with propanolol on AT in patients with coronary artery disease (CAD). Eight men and one woman with significant (CAD),were selected for this study. Each patient completed a maximum treadmill stress test (MTST) following the Bruce protocol on propanolol 40-160 mg/day as a control study. Cardiorespiratory variables were measured at rest and at each stage of the treadmill test. These patients underwent an exercise training programme for 12-16 weeks on the same dose of propanolol. Training sessions were for a minimum of 30-40 minutes, 3 times a week, with training heart rate of 75%-85% of the pretraining peak heart rate. Training heart rate ranged from 98 to 128 beats/min. They were retested with a MTST after the training programme, on the same dose of propanolol. AT was calculated noninvasively by measuring respiratory variables every 30 seconds in relation to work increment. AT was identified by measuring the time course of VE, VCO2, VE/V02, etc. in relation to incremental work. The mean values of V02, 02 P and % V02 max at AT before and after training on propanolol were as follows: V02 = 1.43 L/min ± .25 and 1.86 L/min ± .44, 02P = 14.35 ± 2.40 and 18.73 ± 4.00 ml/beat, % of V02 max = 68.20 ± 6.31 and 73.59 5.84. The mean changes of VO2 02 P, and % of VO2 max were + 0.43 L/min ± 0.20 (P < .003), + 4.38 ± 2.55 (P < 0.03) and ± 5.07% + 4.84 (P < .0011). After exercise training on propanolol, the mean peak exercise tolerance time and absolute V02 max increased by 2.8 min (from 9.0 to 11.8 min) (P <.001) and 22.7% (P <.007), respectively. We conclude that the increase in anaerobic threshold in patients with coronary artery disease may be due to improvement in V02 max, increased stroke volume, and peripheral 02 extraction.

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Section: Discussionmentioning

confidence: 94%