Altered Ets transcription factor activity in prostate tumor cells inhibits anchorage-independent growth, survival, and invasiveness

Foos, Gabriele; Hauser, Craig A.

doi:10.1038/sj.onc.1203946

Cited by 36 publications

(30 citation statements)

References 42 publications

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“…Furthermore, ErbB2/PDEF and CSF-1R/PDEF cells formed highly invasive structures in three-dimensional cultures. The ability of PDEF to induce invasive activity is consistent with previous reports that other Ets factors including Ets1, Ets2, and ESE-1 also promote invasion (1,7,10,(33)(34)(35). Because expression of ErbB2 or CSF-1R/ CSF-1 alone does not stimulate motility or invasion of MCF-10A cells, our findings suggest that PDEF can synergize with hyperstimulated RTKs, such as ErbB2 or CSF-1R/CSF-1, to promote these cellular processes.…”

Section: Discussionsupporting

confidence: 79%

“…Several Ets factors including Ets1, Ets2, and ESE-1 are overexpressed in both murine and human mammary tumors and are thought to be predictors of poor prognosis (1)(2)(3)(4)(5). In addition, overexpression of an inhibitory mutant of Ets2 was sufficient to revert Ras transformation of NIH 3T3 cells and to block anchorage-independent growth and invasion in various breast tumor cell lines (6)(7)(8)(9)(10). Notably, both Ets1 and Ets2 are primarily detected in the stromal compartment of tumors and thought to alter the tumor microenvironment by regulating matrix-remodeling proteins (3,(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

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Novel Role for PDEF in Epithelial Cell Migration and Invasion

et al. 2005

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Cell migration and invasion are two critical cellular processes that are often deregulated during tumorigenesis. To identify factors that contribute to oncogenic progression by stimulating cell migration, we conducted a powerful retroviral based migration screen using an MCF7 cDNA library and the immortalized human breast epithelial cell line MCF-10A. We identified prostate derived Ets factor (PDEF), an Ets transcription factor that is overexpressed in both prostate and breast carcinoma, as a candidate promigratory gene from this screen. Whereas PDEF induced limited motility of MCF-10A

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Novel Role for PDEF in Epithelial Cell Migration and Invasion

et al. 2005

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“…In the same system, HGF induced invasion was partially dependent upon PEA3/E1AF mediated induction of MMP9 (Hanzawa et al, 2000). Dominant-negative constructs consisting of the Ets domain of Ets-2 inhibit anchorage independent growth and invasion of BT20 breast carcinoma cells (Sapi et al, 1998) and PPC-1 prostate carcinoma cells (Foos and Hauser, 2000). These studies confirm that expression of Ets family members, particularly, Ets-1, Ets-2 and PEA3/E1AF, is necessary and sufficient for invasiveness in metastatic human tumor cells.…”

Section: Etsmentioning

confidence: 95%

Transcription factors control invasion: AP-1 the first among equals

et al. 2006

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“…Overexpression of wild type Ets-2 in neuronal cells (44), the prostate tumor cell line PPC-1 (45), and in transgenic thymocytes that express Ets-2 from the sheep metallothionein promoter results in an increase in cell death (46). Zaldumbide et al (27) also overexpressed wild type Ets-2 in developing thymocytes, but they used the proximal Lck promoter and did not observe an increase in apoptosis.…”

Section: Discussionmentioning

confidence: 99%