1989
DOI: 10.1111/j.1600-0765.1989.tb02002.x
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Altered distribution of type I collagen mRNA in periodontal disease

Abstract: Earlier studies on collagen metabolism in the periodontium have suggested that periodontal disease is associated with reduced amounts of type I collagen in the pocket walls, and with an overall increase in collagen synthesis. In this study we analyzed gingival biopsies of patients suffering from adult type chronic periodontal disease by in situ hybridization, which permitted localization of fibroblasts containing different amounts of proa(I) collagen mRNA. The results showed that expression of type I collagen … Show more

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Cited by 18 publications
(9 citation statements)
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“…Apart from the endothelial cell the plasma cell was the most heavily stained cell type in all of the sections. Other cell types stained to a lesser extent confirming the observations of previous studies (Takahashi et al 1996, Larjava et al 1989, Abe et al 1994.…”
Section: Discussionsupporting
confidence: 90%
“…Apart from the endothelial cell the plasma cell was the most heavily stained cell type in all of the sections. Other cell types stained to a lesser extent confirming the observations of previous studies (Takahashi et al 1996, Larjava et al 1989, Abe et al 1994.…”
Section: Discussionsupporting
confidence: 90%
“…In addition, IL-10, which is produced primarily by macrophages, was detected among the vast array of cytokines induced by P. gingivalis infection. IL-10 tends to upregulate the M2 macrophage phenotype, which potentially could lead to an increase in arginase production, resulting in collagen accumulation and fibrosis of gingival tissue, which is a common clinical characteristic of chronic periodontitis (101)(102)(103)(104). A significant reduction in the level of P. gingivalis infection was observed in the mice treated with clodronate liposomes relative to the untreated, but infected, animals (Fig.…”
Section: Figurementioning
confidence: 77%
“…M2 macrophages have been shown play a role in tissue remodelling by increasing the production of effectors that both synthesize and degrade collagen (59) and are becoming the focus of research in fibrotic diseases (60,61). Fibrotic gingival tissue is commonly observed in chronic periodontitis (25), and gingival fibroblasts have been thought to be largely responsible for collagen remodelling during disease (62). However, an M2 macrophage marker, CD163 (RM3/1), found associated with healthy gingival tissue, also has been found in chronically inflamed periodontal tissue (63,64).…”
Section: Discussionmentioning
confidence: 99%