Altered distribution of NK and NKT cells in follicular fluid is associated with IVF outcome

Křižan, J; Cuchalová, Lucie; Šíma, Petr; Králíčková, Milena; Madar, J; Větvička, Václav

doi:10.1016/j.jri.2009.05.005

Cited by 21 publications

(10 citation statements)

References 19 publications

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“…Cytotoxic peptides, such as defensins, have been detected in human follicular fluid, but there was no correlation between defensin concentration and fertility in those patients 22 . Pregnancy outcomes after IVF were greater in women who had fewer NKT (CD56 + CD3 + ) cells and more immunoregulatory NK (CD56 + CD16 − ) cells 23 . In summary, data collected using multiple species – rodents, rabbits, cows and humans – collectively point to an important role for leukocytes in follicular development and ovulation; however, domestic animal models have been less well studied in regard to the involvement of the immune system in follicular development.…”

Section: Leukocytes In Follicular Development Ovulation and Luteinizmentioning

confidence: 99%

The Interface of the Immune and Reproductive Systems in the Ovary: Lessons Learned from the Corpus Luteum of Domestic Animal Models

Pate

Toyokawa

Walusimbi

et al. 2010

American J Rep Immunol

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Citation Pate JL, Toyokawa K, Walusimbi S, Brzezicka E. The interface of the immune and reproductive systems in the ovary: lessons learned from the corpus luteum of domestic animal models. Am J Reprod Immunol 2010 The dynamic changes that characterize the female reproductive system are regulated by hormones. However, local cell‐to‐cell interactions may mediate responsiveness of tissues to hormonal signals. The corpus luteum (CL) is an excellent model for understanding how immune cells are recruited into tissues and the role played by those cells in regulating tissue homeostasis or demise. Leukocytes are recruited into the CL throughout its lifespan, and leukocyte‐derived cytokines have been found in corpora lutea of all species examined. The proinflammatory cytokines inhibit gonadotropin‐stimulated steroidogenesis, profoundly stimulate prostaglandin synthesis by luteal cells, and promote apoptosis. However, there is mounting evidence that leukocytes and luteal cells communicate in different ways to maintain homeostasis within the functional CL. Domestic animals have provided important information regarding the presence and role of immune cells in the CL.

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Section: Leukocytes In Follicular Development Ovulation and Luteinizmentioning

confidence: 99%

The Interface of the Immune and Reproductive Systems in the Ovary: Lessons Learned from the Corpus Luteum of Domestic Animal Models

Pate

Toyokawa

Walusimbi

et al. 2010

American J Rep Immunol

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“…However, the success rate of IVF on the firstattempt,especiallyinolderfemales,islow.Predictivecriteria to select the best embryo for a single embryo transfer remain elusive. Tools for selecting embryos for transfer, such as visual morphological assessments, including blastocyst and blastocoels, and measurement of the hormone concentrations in follicular fluid, are often inadequate for identifying the embryo with the best potential to establish a pregnancy [4,14,15,20].…”

Section: Introductionmentioning

confidence: 99%

A proteomic analysis of human follicular fluid: comparison between fertilized oocytes and non-fertilized oocytes in the same patient

Bayasula

Iwase

Kobayashi

et al. 2013

J Assist Reprod Genet

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Purpose Human follicular fluid constitutes the microenvironment of follicles and includes various biological active proteins that can affect follicle growth and oocyte fertilization. Conducting proteomic evaluations of human follicular fluid may be helpful for identifying potential biomarkers possibly possessing a predictive value for oocyte quality and the success of in vitro fertilization. Method We performed proteomic profiling of human follicular fluids containing oocytes that were fertilized and resulted in pregnancy and follicular fluids containing oocytes that were not fertilized in the same patients undergoing intracytoplasmic sperm injection using the LTQ Orbitrap coupled with liquid chromatography-tandem mass spectrometry (LC/MS/MS) analyses. ResultsWe identified a total of 503 proteins in human follicular fluids containing fertilized and non-fertilized oocytes obtained from 12 patients. We also found that 53 proteins exhibited significantly different spectral counts between the two groups, including heparan sulfate proteoglycan perlecan, which showed significant upregulation in the follicular fluids containing fertilized oocytes in comparison with that observed in the follicular fluids containing non-fertilized oocytes. Conclusion Our results suggest a possibility that proteins identified by LC/MS/MS in follicular fluid might not only be involved in folliculogenesis, but also function as biomarkers possessing predictive potential for oocyte maturation and the success of IVF when their expression levels are significantly different between fertilized and non-fertilized oocytes, although no distinctive biomarkers were identified in the current study.

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“…In PE, iNKT cells have a stronger tendency to activate signals than those in normal pregnancy, and the population of activated iNKT cells that secrete IFN‐γ in PE is significantly higher. J. Krizan et al reported that increased NKT cells in blood may result in recurrent pregnancy abortion . In normal pregnancy, there is an accumulation of iNKT cells that produce IFN‐γ in the decidua, while iNKT cells in the peripheral blood show a TH2 profile.…”

Section: Innate Immunitymentioning

confidence: 99%

The role of immunity in the pathogenesis and development of pre‐eclampsia

2019

Scand J Immunol

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Pre-eclampsia (PE) is a leading cause of maternal and perinatal morbidity and mortality; however, the aetiology of PE still remains unclear. It has been widely accepted that the disease results from insufficient spiral artery remodelling, leading to placental ischaemia and the release of a variety of factors. In recent decades, a large number of studies have observed an abnormal immune response in preeclamptic women and studies of both patients and animal models have shown alterations in the function or the number of immune agents. Thus, researchers believe that alterations in the immune system may contribute to the genesis and pathophysiology of PE. Therefore, identifying the role of the immune system can not only shed light on the nature of PE but also contribute to the development of diagnostic and therapeutic methods for PE. This review focuses on the current knowledge of the immune system including both innate and adaptive immunity and sheds light on their role in PE. Additionally, advances in potential therapeutic measures are discussed.

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Altered distribution of NK and NKT cells in follicular fluid is associated with IVF outcome

Cited by 21 publications

References 19 publications

The Interface of the Immune and Reproductive Systems in the Ovary: Lessons Learned from the Corpus Luteum of Domestic Animal Models

The Interface of the Immune and Reproductive Systems in the Ovary: Lessons Learned from the Corpus Luteum of Domestic Animal Models

A proteomic analysis of human follicular fluid: comparison between fertilized oocytes and non-fertilized oocytes in the same patient

The role of immunity in the pathogenesis and development of pre‐eclampsia

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