Altered cytokine production in the elderly

Rink, Lothar; Cakman, Irem; Kirchner, Holger

doi:10.1016/s0047-6374(97)00153-x

Cited by 340 publications

(190 citation statements)

References 30 publications

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“…Age-related changes show an increased responses and inflammation. Previous studies have shown decreased secretion of IFN-γ and IL-2 in the aged, which are known to be correlated to a change of differentiation and proliferation of the lymphocytes (Rink et al, 1998). In our data, the proliferative response of spleen lymphocytes to ConA stimuli was significantly decreased in the aged mice.…”

Section: Discussionsupporting

confidence: 71%

“…In vitro studies on the effects of age on cell-mediated immunity have mainly focused on the response of T lymphocytes to mitogenic stimuli. The age-related decline of immunity is manifested mainly by impairment in the lymphoproliferative response (Solana et al, 1991;Song et al, 1993) and cytokine secretion (Rink et al, 1998) to mitogenic stimuli. Cytokines are a key component in the regulatory communication among immune cells; they are responsible for the differentiation, proliferation and survival of the lymphoid cells and play an important role in immune sensitized mice.…”

Section: Hemohim Recovers the Declined Nk Cell Activity In Aged Micementioning

confidence: 99%

“…Murine models of aging demonstrated that there was an ageassociated dysregulation in the cytokine production, as evidenced by the consistently decreased production of IL-2 (Shearer, 1997) and a generally increased production of IL-4 (Hobbs et al, 1993;Albright et al, 1995). Also, up-regulated IL-4, IL-5 and IL-10 production due to aging have been reported (Rink et al, 1998). These results suggest that aging is associated with a shift that can be at least partially attributed to a change in the phenotypic profile of T cells.…”

Section: Introductionmentioning

confidence: 99%

“…Another serious problem is that aging involves a shift towards a dominance of a Th2 related response (Shearer, 1997;Rink et al, 1998;Albers et al, 2005;Alberti et al, 2006). The impact of age on cytokine production was examined in both animal and human models in an effort to elucidate the possible mechanisms of age-associated changes in immunity.…”

Section: Introductionmentioning

confidence: 99%

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Restoration of the immune functions in aged mice by supplementation with a new herbal composition, HemoHIM

Park¹,

Jo²,

Jung³

et al. 2007

Phytotherapy Research

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The effect of a new herbal composition, HemoHIM, on immune functions was examined in aged mice, in which various immune responses had been impaired. The composition HemoHIM was prepared by adding the ethanol-insoluble fraction to the total water extract of a mixture of three edible herbs, Angelica Radix, Cnidium Rhizoma and Paeonia Radix. Supplementation to the aged mice with HemoHIM restored the proliferative response and cytokine production of splenocytes with a response to ConA. Also, HemoHIM recovered the NK cell activity which had been impaired in the aged mice. Meanwhile aging is known to reduce the Th1-like function, but not the Th2-like function, resulting in a Th1/Th2 imbalance. HemoHIM restored the Th1/Th2 balance in the aged mice through enhanced IFN-γ γ γ γ γ and IgG2a production, and conversely a reduced IL-4 and IgG1 production. It was found that one factor for the Th1/Th2 imbalance in the aged mice was a lower production of IL-12p70. However, HemoHIM restored the IL-12p70 production in the aged mice. These results suggested that HemoHIM was effective for the restoration of impaired immune functions of the aged mice and therefore could be a good recommendation for immune restoration in elderly humans.

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Section: Discussionsupporting

confidence: 71%

Section: Hemohim Recovers the Declined Nk Cell Activity In Aged Micementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Restoration of the immune functions in aged mice by supplementation with a new herbal composition, HemoHIM

Park¹,

Jo²,

Jung³

et al. 2007

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…The production of the type 1 cytokine IFN-␥ has been reported to be increased (32)(33)(34) or decreased (35)(36)(37) in aged mice and humans. Also, the production of type 2 cytokines such as IL-4 and IL-5 has been reported to be increased (38,39) or decreased (33,35) in vitro.…”

mentioning

confidence: 99%

Impaired GATA3-Dependent Chromatin Remodeling and Th2 Cell Differentiation Leading to Attenuated Allergic Airway Inflammation in Aging Mice

Hasegawa

Miki

Hosokawa

et al. 2006

The Journal of Immunology

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Age-related changes in lymphocytes are most prominent in the T cell compartment. There have been substantial numbers of reports on T cell function in aged mice and humans, such as on the production of Th1 and Th2 cytokines, but the results show considerable variation and contradictions. In the present study, we used 8- to 12-mo-old aging mice and a well-established in vitro Th1/Th2 cell differentiation culture system to identify molecular defects in Th1/Th2 cell differentiation that can be detected in the relatively early stages of aging. The capability to differentiate into Th2 cells is reduced in aging mouse CD4+ T cells. Decreased activation of the ERK MAPK cascade upon TCR stimulation, but normal intracellular-free calcium ion concentration mobilization and normal IL-4-induced STAT6 activation were observed in aging mouse CD4+ T cells. In addition, reduced expression of GATA3 was detected in developing Th2 cells. Chromatin remodeling of the Th2 cytokine gene locus was found to be impaired. Th2-dependent allergic airway inflammation was milder in aging mice compared with in young adult mice. These results suggest that the levels of Th2 cell differentiation and resulting Th2-dependent immune responses, including allergic airway inflammation, decline during aging through defects in the activation of the ERK MAPK cascade, expression of GATA3 protein and GATA3-dependent chromatin remodeling of the Th2 cytokine gene locus. In the present study, we provide the first evidence indicating that a chromatin-remodeling event in T cells is impaired by aging.

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