Altered coupling of default-mode, executive-control and salience networks in Internet gaming disorder

Zhang, J.T.; Ma, Shan-Shan; Chen, Yan; Zhang, S.; Liu, L.; Wang, L.-J.; Liu, B.; Yao, Yuan‐Wei; Yang, Yihong; Fang, Xiaoyi

doi:10.1016/j.eurpsy.2017.06.012

Cited by 33 publications

(39 citation statements)

References 76 publications

(127 reference statements)

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“…Altered interaction between the SN and other brain networks has been suggested to contribute to the motivational, affective, and cognitive characteristics observed in addiction ( 62 ). Our current results and previous evidence ( 63 ) indicate that FC alterations in the SN, especially hyperconnectivity between the DMN and the SN, play pivotal roles in the pathophysiology of IGD. IGD subjects without comorbid depression also showed stronger sgACC FC with the left dlPFC than the other groups.…”

Section: Discussionsupporting

confidence: 80%

Subregions of the Anterior Cingulate Cortex Form Distinct Functional Connectivity Patterns in Young Males With Internet Gaming Disorder With Comorbid Depression

Lee

Namkoong

et al. 2018

Front. Psychiatry

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Depression is one of the most common comorbid conditions in Internet Gaming Disorder (IGD). Although there have been many studies on the pathophysiology of IGD, the neurobiological basis underlying the close association between depression and IGD has not been fully clarified. Previous neuroimaging studies have demonstrated functional and structural abnormalities in the anterior cingulate cortex (ACC) in IGD patients. In this study, we explored functional connectivity (FC) abnormalities involving subregions of the ACC in IGD subjects with comorbid depression. We performed a resting state seed-based FC analysis of 21 male young adults with IGD with comorbid depression (IGDdep+ group, 23.6 ± 2.4 years), 22 male young adults without IGD with comorbid depression (IGDdep− group, 24.0 ± 1.6 years), and 20 male age-matched healthy controls (24.0 ± 2.2 years). ACC-seeded FC was evaluated using the CONN-fMRI FC toolbox. The dorsal ACC (dACC), the pregenual ACC (pgACC), and the subgenual ACC (sgACC) were selected as seed regions. Both IGD groups had stronger pgACC FC with the right precuneus, the posterior cingulate cortex, and the left inferior frontal gyrus/insula than the control group. The IGDdep+ group had stronger dACC FC with the left precuneus and the right cerebellar lobule IX than the control and IGDdep- groups. The IGDdep+ group also had weaker pgACC FC with the right dorsomedial prefrontal cortex and the right supplementary motor area and had weaker sgACC FC with the left precuneus, the left lingual gyrus, and the left postcentral gyrus than the other groups. The strength of the connectivity between the sgACC and the left precuneus correlated positively with a higher omission error rate in the continuous performance test in the IGDdep+ group. In addition, the IGDdep– group had stronger sgACC FC with the left dorsolateral prefrontal cortex than the other groups. Our findings suggest that young males with IGD comorbid with depression have FC alterations of the default mode network and diminished FC with the prefrontal cortex. This altered FC pattern may be involved in the close association of IGD and depression.

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Section: Discussionsupporting

confidence: 80%

Subregions of the Anterior Cingulate Cortex Form Distinct Functional Connectivity Patterns in Young Males With Internet Gaming Disorder With Comorbid Depression

Lee

Namkoong

et al. 2018

Front. Psychiatry

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“…The precuneus comprises a central region of the default mode network 79 , which has the highest metabolic response during rest 80 and strong connections with adjacent and remote regions 81 . A dysfunctional default mode network has been reported in chronic cocaine users 82 , 83 , people with Internet use disorders 84 – 86 , and heroin dependent patients 87 . A recent review of addiction and precuneus function summarized evidence that the precuneus has been repeatedly implicated in exteroceptive processes, which play a critical role in the conditioned cue response in addiction 88 .…”

Section: Discussionmentioning

confidence: 99%

Effects of early ketamine exposure on cerebral gray matter volume and functional connectivity

Hung

Liu²,

Huang

et al. 2020

Sci Rep

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Ketamine has been used for medical purposes, most typically as an anesthetic, and recent studies support its use in the treatment of depression. However, ketamine tends to be abused by adolescents and young adults. In the current study, we examined the effects of early ketamine exposure on brain structure and function. We employed MRI to assess the effects of ketamine abuse on cerebral gray matter volume (GMV) and functional connectivity (FC) in 34 users and 19 non-users, employing covariates. Ketamine users were categorized as adolescent-onset and adult-onset based on when they were first exposed to ketamine. Imaging data were processed by published routines in SPM and AFNI. The results revealed lower GMV in the left precuneus in ketamine users, with a larger decrease in the adolescent-onset group. The results from a seed-based correlation analysis show that both ketamine groups had higher functional connectivity between left precuneus (seed) and right precuneus than the control group. Compared to controls, ketamine users showed decreased GMV in the right insula, left inferior parietal lobule, left dorsolateral prefrontal cortex/superior frontal gyrus, and left medial orbitofrontal cortex. These preliminary results characterize the effects of ketamine misuse on brain structure and function and highlight the influence of earlier exposure to ketamine on the development of the brain. The precuneus, a structure of central importance to cerebral functional organization, may be particularly vulnerable to the influences of early ketamine exposure. How these structural and functional brain changes may relate to the cognitive and affective deficits remains to be determined with a large cohort of participants.

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“…Growing evidence suggests that addictions are not only associated with structural and functional breakdown of isolated regions but rather with system-level alterations between brain regions 14 . Functional brain imaging data have revealed that the human brain is topologically organized into a set of coherent spatio-temporal networks, such as default-mode network (DMN) 15 . The DMN was first mentioned by Shulman in 1997 16 who noted several brain areas in the cerebral cortex that constantly decreased their activity while performing highly demanding tasks.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies revealed altered DMN in addictions. These researches focused primarily on gambling disorder 20 and Internet gaming disorder 15,20 or substance addictions, such as heroin 21 , alcohol 22 , nicotine 23 , and cannabis 24 . It was also demonstrated that functional connectivity within DMN may predict successful quitting 25 , the intensity of withdrawal-induced craving 26 and the degree of cognitive decline 27 in addictions.…”

Section: Introductionmentioning

confidence: 99%

Internet addiction and functional brain networks: task-related fMRI study

Darnai

Perlaki

Zsidó

et al. 2019

Sci Rep

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A common brain-related feature of addictions is the altered function of higher-order brain networks. Growing evidence suggests that Internet-related addictions are also associated with breakdown of functional brain networks. Taking into consideration the limited number of studies used in previous studies in Internet addiction (IA), our aim was to investigate the functional correlates of IA in the default mode network (DMN) and in the inhibitory control network (ICN). To observe these relationships, task-related fMRI responses to verbal Stroop and non-verbal Stroop-like tasks were measured in 60 healthy university students. The Problematic Internet Use Questionnaire (PIUQ) was used to assess IA. We found significant deactivations in areas related to the DMN (precuneus, posterior cingulate gyrus) and these areas were negatively correlated with PIUQ during incongruent stimuli. In Stroop task the incongruent_minus_congruent contrast showed positive correlation with PIUQ in areas related to the ICN (left inferior frontal gyrus, left frontal pole, left central opercular, left frontal opercular, left frontal orbital and left insular cortex). Altered DMN might explain some comorbid symptoms and might predict treatment outcomes, while altered ICN may be the reason for having difficulties in stopping and controlling overuse.

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Altered coupling of default-mode, executive-control and salience networks in Internet gaming disorder

Abstract: These findings suggest that the deficient modulation of ECN versus DMN by SN might provide a mechanistic framework to better understand the neural basis of IGD and might provide novel evidence for the triple-network model in IGD.

Cited by 33 publications

References 76 publications

Subregions of the Anterior Cingulate Cortex Form Distinct Functional Connectivity Patterns in Young Males With Internet Gaming Disorder With Comorbid Depression

Subregions of the Anterior Cingulate Cortex Form Distinct Functional Connectivity Patterns in Young Males With Internet Gaming Disorder With Comorbid Depression

Effects of early ketamine exposure on cerebral gray matter volume and functional connectivity

Internet addiction and functional brain networks: task-related fMRI study

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