Altered Corticostriatal Functional Connectivity in Obsessive-compulsive Disorder

Harrison, Ben J; Soriano‐Mas, Carles; Pujol, Jesús; Ortiz, Héctor; López‐Solà, Marina; Hernández‐Ribas, Rosa; Deus, Joan; Alonso, Pino; Yücel, Murat; Pantelis, Christos; Menchón, José M.; Cardoner, Narcı́s

doi:10.1001/archgenpsychiatry.2009.152

Cited by 514 publications

(523 citation statements)

References 87 publications

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“…Compared to healthy individuals, the patients with OCD showed excessive coupling between the caudate and midline frontal areas such as the sgACC, vmPFC, and dmPFC [68]. Thus, it is likely that a dys-regulated prediction error can result in an urge-toreact with excessive caudate activation and functional coupling between the caudate and the sgACC, vmPFC, and dmPFC.…”

Section: Dys-regulation Of the Agir Modelmentioning

confidence: 99%

Healing Dysfunctional Identity: Bridging Mind-Body Intervention to Brain Systems

Ho¹,

Nakamura²

2017

JBBS

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In this paper, we aim to use an innovative model to integrate applied work on a fast-acting mind-body intervention, Mind-Body Bridging (MBB), with theoretical work based on psychology and neuroscience. In an affect-object generative inference and regulation (AGIR) model, we propose that functional dynamics between two systems, the affect-object thought generation system and the cognitive control system, can guide an individual to achieve homeostasis within self and harmonious relationships with others. We used Neurosynth (www.neurosynth.org), an automated meta-analysis database, to identify potential brain substrates underlying the key components in the AGIR model. Based on the findings, some brain regions are implicated as the key cortical substrates in this model, corroborating our central hypothesis that a hallmark of mind-body wellbeing can be characterized as a low-frequency anti-correlantion between 1) the cognitive control system including the dorsal anterior/middle cingulate cortex, and 2) the affect-object thought generation system including the ventromedial prefrontal cortex and posterior cingulate cortex. MBB provides an efficient strategy for responding to and dissolving a fundamental problem that impairs mind-body wellbeing, i.e., unrealistic identity-grasping consisting of self-centered embodied expectations of self and others. We demonstrated how theoretical and applied work could be integrated by drawing evidence from the neuroscience literature to support the AGIR model, and then we applied the AGIR model to elucidate how MBB might work.

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Section: Dys-regulation Of the Agir Modelmentioning

confidence: 99%

Healing Dysfunctional Identity: Bridging Mind-Body Intervention to Brain Systems

Ho¹,

Nakamura²

2017

JBBS

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show abstract

“…The symptoms are debilitating, and involve a variety of unwanted thoughts and urges, and associated compulsions. Neuroimaging investigations have shown that OCD symptoms are associated with abnormally enhanced functional connectivity between the ventral caudate/nucleus accumbens and the anterior orbitofrontal cortex in the resting state (Harrison et al, 2009(Harrison et al, , 2013. In line with this, there is evidence to suggest that activity in OFC is increased in OCD (for review see A c c e p t e d M a n u s c r i p t Sale et al,26 engagement might also be a good candidate for reducing context-driven symptoms of OCD.…”

Section: Obsessive-compulsive Disordermentioning

confidence: 99%

Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation

Sale¹,

Mattingley²,

Zalesky³

et al. 2015

Neuroscience & Biobehavioral Reviews

121

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“…The core alteration involves enhancement of functional connectivity between the prefrontal cortex and the ventral stria tum that co-occurs with an opposite pattern of reduced connectivity in surrounding cortical areas. 10,11 The morphology of the frontobasal systems is also subtly altered in patients with OCD. [12][13][14] In patients with Prader Willi syndrome, measurements of brain regional tissue volume, 15,16 perfusion,…”

Section: Introductionmentioning

confidence: 99%

Anomalous basal ganglia connectivity and obsessive–compulsive behaviour in patients with Prader Willi syndrome

Pujol

Blanco‐Hinojo

Esteba-Castillo

et al. 2016

jpn

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Altered Corticostriatal Functional Connectivity in Obsessive-compulsive Disorder

Abstract: This study directly supports the hypothesis that OCD is associated with functional alterations of brain corticostriatal networks. Specifically, our findings emphasize abnormal and heightened functional connectivity of ventrolimbic corticostriatal regions in patients with OCD.

Cited by 514 publications

References 87 publications

Healing Dysfunctional Identity: Bridging Mind-Body Intervention to Brain Systems

Healing Dysfunctional Identity: Bridging Mind-Body Intervention to Brain Systems

Imaging human brain networks to improve the clinical efficacy of non-invasive brain stimulation

Anomalous basal ganglia connectivity and obsessive–compulsive behaviour in patients with Prader Willi syndrome

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