Altered cortical thickness, degree centrality, and functional connectivity in middle-age type 2 diabetes mellitus

Kang, Shangyu; Chen, Yuna; Wu, Jinjian; Liang, Yi; Rao, Yawen; Yue, Xiaomei; Lyu, Wenjiao; Li, Yifan; Tan, Xin; Huang, Haoming; Qiu, Shijun

doi:10.3389/fneur.2022.939318

Cited by 3 publications

(3 citation statements)

References 65 publications

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“…Except for the correlations between rs-fMRI indices, no significant correlation between rs-fMRI indices and clinical parameters or cognitive performance was observed. Studies focusing on T2DM patients without cognitive impairment detected little direct relationship between cognitive performances and rs-fMRI measurements (Liu et al, 2017Kang et al, 2022). A task-fMRI based study indicated mediation effects among olfactory dysfunction, pancreatic function and executive function in T2DM patients without cognitive impairment (Zhang et al, 2018).…”

Section: Discussionmentioning

confidence: 98%

Alterations of spontaneous brain activity in type 2 diabetes mellitus without mild cognitive impairment: a resting-state functional magnetic resonance study

Wang,

Hou,

Jiang

et al. 2024

Front. Hum. Neurosci.

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BackgroundType 2 diabetes mellitus (T2DM) has been demonstrated an increased risk factor of cognitive impairment or even dementia. Kinds of resting-state functional magnetic resonance imaging indices have been proposed and used to investigate the brain mechanism underlying diabetic cognitive impairment. This study aimed to explore the early changes in spontaneous neural activity among T2DM patients without cognitive impairment by means of multiple rs-fMRI indices.MethodsT2DM patients without cognitive impairment and age-, sex-, and education matched control subjects were included in this study. Three rs-fMRI indices, namely amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo) and voxel-mirrored homotopic connectivity (VMHC) were computed after image pre-processing. The Montreal Cognitive Assessment (MoCA) was performed to distinguish normal cognition. Brain volume was also evaluated. Correlation analyses were conducted to explore any relationship among rs-fMRI indices and clinical characteristics.ResultsThe T2DM patients were detected significantly decreased neural activity in right angular and left prefrontal gyrus including middle and superior frontal gyrus. Increased activities were also observed in left caudate and the supplementary motor area. No correlation between rs-fMRI indices and clinical characteristics was survived after multiple comparison correction. But we observed a significant, but decreased correlation between ALFF and ReHo values in the reported brain areas.ConclusionThe combination of ALFF, ReHo and VMHC analyses demonstrated abnormal spontaneous neural activity in brain regions which were reported in T2DM patients without cognitive impairment. These results may enhance our understanding of the diabetic brain changes at the early stage.

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Section: Discussionmentioning

confidence: 98%

Alterations of spontaneous brain activity in type 2 diabetes mellitus without mild cognitive impairment: a resting-state functional magnetic resonance study

Wang,

Hou,

Jiang

et al. 2024

Front. Hum. Neurosci.

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“…The differences in the node topological properties showing significant differences between the T2DM and HC groups. Functional impairments (represented by DC values) and structural impairments of the precuneus region have been widely reported in T2DM patients (Chen et al, 2015Kang et al, 2022). The precuneus is a highly connected network hub region and an important part of the default mode network, and is involved in many high-order complex cognitive processes (Cavanna and Trimble, 2006).…”

Section: Altered Nodal Properties In Cortical Structural Network In T2dmmentioning

confidence: 99%

Altered cortical thickness-based structural covariance networks in type 2 diabetes mellitus

Huang,

Zhang,

Cheng

et al. 2024

Front. Neurosci.

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Cognitive impairment is a common complication of type 2 diabetes mellitus (T2DM), and early cognitive dysfunction may be associated with abnormal changes in the cerebral cortex. This retrospective study aimed to investigate the cortical thickness-based structural topological network changes in T2DM patients without mild cognitive impairment (MCI). Fifty-six T2DM patients and 59 healthy controls underwent neuropsychological assessments and sagittal 3-dimensional T1-weighted structural magnetic resonance imaging. Then, we combined cortical thickness-based assessments with graph theoretical analysis to explore the abnormalities in structural covariance networks in T2DM patients. Correlation analyses were performed to investigate the relationship between the altered topological parameters and cognitive/clinical variables. T2DM patients exhibited significantly lower clustering coefficient (C) and local efficiency (Elocal) values and showed nodal property disorders in the occipital cortical, inferior temporal, and inferior frontal regions, the precuneus, and the precentral and insular gyri. Moreover, the structural topological network changes in multiple nodes were correlated with the findings of neuropsychological tests in T2DM patients. Thus, while T2DM patients without MCI showed a relatively normal global network, the local topological organization of the structural network was disordered. Moreover, the impaired ventral visual pathway may be involved in the neural mechanism of visual cognitive impairment in T2DM patients. This study enriched the characteristics of gray matter structure changes in early cognitive dysfunction in T2DM patients.

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“…SBM has been applied to investigate cerebral cortical abnormalities in neuropsychiatric disorders, such as Alzheimer’s disease ( Nho et al, 2012 ), schizophrenia ( Palaniyappan and Liddle, 2012 ), autism ( Nordahl et al, 2007 ), etc. Several studies have recently begun to explore alterations in SBM indices in T2DM patients ( Kang et al, 2022 ; Shao et al, 2022 ). In addition, it has also been demonstrated that cytokines and brain-derived neurotrophic factor (BDNF) levels may be associated with the development of T2DM-related cognitive impairment ( Zhen et al, 2013 ; Simo et al, 2017 ; Sun et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Alterations of peripheral cytokines, BDNF, and surface-based morphometry indices in T2DM patients without cognitive impairment

et al. 2023

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PurposeThis study aimed to investigate potential biological mechanisms underlying cognitive function alterations in Type 2 diabetes mellitus (T2DM) patients by integrating cortical morphology with peripheral cytokine levels and brain-derived neurotrophic factor (BDNF) levels, and to offer potential insights for the early detection of T2DM-related cognitive impairment.MethodsThis study included 16 T2DM patients with a Montreal Cognitive Assessment (MoCA) score of at least 26 points, as well as 16 healthy controls with normal cognitive function. The participants also completed the digit span test and digit symbol substitution test. Participants’ serum levels of Interleukin 4 (IL-4), IL-6, IL-10, tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), and BDNF were also examined. Each subject underwent a high-resolution 3T structural brain MRI scan. Based on the aparc. a2009s atlas, we calculated the cortical thickness, sulcus depth, gyrification index, and fractal dimension for each participant using surface-based morphometry (SBM). Correlation analysis between cognitive measures, serum levels of cytokines and BDNF, and SBM indices were further performed.ResultsThe levels of IL-4 and BDNF showed significant group differences. In the T2DM group, the sulcus depth exhibited a significant decrease in the left transverse frontopolar gyri and sulci, as well as in the right pole-occipital; the fractal dimension showed a significant increase in the right posterior-dorsal part of the cingulate gyrus; and the gyrification index significantly increased in the left inferior part of the precentral sulcus and right triangular part of the inferior frontal gyrus. Correlation analysis revealed a significant positive correlation between IL-10 levels and the sulcus depth of left transverse frontopolar gyri and sulci; a significant positive correlation between the sulcus depth of the right pole-occipital and the digit span test-forward scores, and a significant negative correlation between the gyrification index of the left inferior part of the precentral sulcus and the digit span test-backward scores among T2DM participants.ConclusionT2DM patients without cognitive impairment displayed reductions in IL 4 and BDNF levels, as well as significant alterations in their SBM indices, indicating that prior to the emergence of cognitive impairment, the SBM indices, peripheral cytokines, and BDNF may have altered in T2DM patients. IL-10 may lessen inflammation-related brain edema and preserve sulcus depth in T2DM patients through its anti-inflammatory activity.

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Altered cortical thickness, degree centrality, and functional connectivity in middle-age type 2 diabetes mellitus

Cited by 3 publications

References 65 publications

Alterations of spontaneous brain activity in type 2 diabetes mellitus without mild cognitive impairment: a resting-state functional magnetic resonance study

Alterations of spontaneous brain activity in type 2 diabetes mellitus without mild cognitive impairment: a resting-state functional magnetic resonance study

Altered cortical thickness-based structural covariance networks in type 2 diabetes mellitus

Alterations of peripheral cytokines, BDNF, and surface-based morphometry indices in T2DM patients without cognitive impairment

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