Altered cortical thickness and emotional dysregulation in adolescents with borderline personality disorder

Xiao, Qian; Fu, Yan; Yi, Xiaoping; Ding, Jun; Han, Zaide; Zhang, Zhejia; Tan, Ze-ming; Wang, Jing; Wu, Zihao; Pi, Jingying; Chen, Bihong T.

doi:10.1080/20008066.2022.2163768

Cited by 4 publications

(1 citation statement)

References 38 publications

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“…We obtained CT by calculating the shortest distance from the gray/white boundary to the gray/cerebrospinal fluid boundary at each vertex. The SA of each hemisphere is calculated by adding up the area of all tessellations on the gray matter surface (Deng et al ., 2019 ; Qiu et al ., 2014 ; Xiao et al ., 2023 ).…”

Section: Methodsmentioning

confidence: 99%

Sex differences of brain cortical structure in major depressive disorder

Mou,

Zheng,

Long

et al. 2023

Psychoradiology

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Background Major depressive disorder (MDD) has different clinical presentations in males and females. However, the neuroanatomical mechanisms underlying these sex differences are not fully understood. Methods High-resolution T1-weighted images were acquired from 61 patients with MDD and 61 healthy controls (36 females and 25 males, both). The sex differences in cortical thickness (CT) and surface area (SA) were obtained using the FreeSurfer software and compared between every two groups by post-hoc test. Spearman correlation analysis was also performed to explore the relationships between these regions and clinical characteristics. Results In male patients with MDD, the CT of the right precentral was thinner compared to female patients, although not survive Bonferroni correction. The SA of several regions, including right superior frontal, medial orbitofrontal gyrus, inferior frontal gyrus triangle, superior temporal, middle temporal, lateral occipital gyrus, and inferior parietal lobule in female patients with MDD was smaller than that in male patients (p < 0.01 after Bonferroni correction). In female patients, the SA of the right superior temporal (r = 0.438, p = 0.008), middle temporal (r = 0.340, p = 0.043), and lateral occipital gyrus (r = 0.372, p = 0.025) were positively correlated with illness duration. Conclusion The current study provides evidence of sex differences in CT and SA in patients with MDD, which may improve our understanding of the sex-specific neuroanatomical changes in the development of MDD.

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Section: Methodsmentioning

confidence: 99%

Sex differences of brain cortical structure in major depressive disorder

Mou,

Zheng,

Long

et al. 2023

Psychoradiology

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Alteration of prefrontal cortex and its associations with emotional and cognitive dysfunctions in adolescent borderline personality disorder

Xiao,

Shen,

et al. 2024

Eur Child Adolesc Psychiatry

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BackgroundThe neurobiological mechanism of borderline personality disorder (BPD) in adolescents remains unclear. The study aimed to assess the alterations in neural activity within prefrontal cortex in adolescents with BPD and investigate the relationship of prefrontal activity with cognitive function and emotional regulation. MethodsThis study enrolled 50 adolescents aged 12-17 years with BPD and 21 gender and age-matched healthy control (HC) participants. Study assessment for each participant included a brain resting-state functional MRI (rs-fMRI), cognitive testing with Stroop Color-Word Test (SCWT) and clinical assessment questionnaires such as Borderline Personality Features Scale (BPFS), Di culties in Emotion Regulation Scale (DERS), Ottawa Self-Injury Inventory and Childhood Trauma Questionnaire (CTQ). Fractional amplitude of low-frequency uctuations (fALFF) and seed-based functional connectivity (FC) were obtained from rs-fMRI analysis. Correlative analysis was also performed to evaluate the associations of the neuroimaging metrics such as fALFF and FC with cognitive testing scores and clinical assessment questionnaire scores. ResultsAdolescents with BPD showed increased fALFF values in the right inferior frontal gyrus and decreased activity in the left middle frontal gyrus as compared to the HC group (p < 0.05, cluster size ≥ 100, FWE correction). In adolescents with BPD, the reduced fALFF in the left middle frontal gyrus was associated with SCWT-A (reading characters) and SCWT-B (reading color). Increased fALFF in the right inferior frontal gyrus was related to BPFS, DERS-F and Ottawa Self-Injury Inventory-4C. Additionally, both the fALFF values in the left middle frontal gyrus and the right inferior frontal gyrus were related to the CTQ-D (emotional neglect) (p < 0.05). The left middle frontal gyrus exhibited increased FC with the right hippocampus, left inferior temporal gyrus and right inferior frontal gyrus (voxel p < 0.001, cluster p < 0.05, FWE correction). The increased FC between the left middle frontal gyrus and the right hippocampus was related to SCWT-C (cognitive exibility). ConclusionsWe observed diverging changes in intrinsic brain activity in prefrontal cortex, and neural compensatory FC changes to maintain function in adolescents with BPD. In addition, increased neural function as indicated by brain activity and FC was associated with cognitive dysfunction, while decreased neural Page 4/24 function was closely associated with emotional dysregulation. These results indicated that alterations of intrinsic brain activity may be one of the underlying neurobiological markers for clinical symptoms in adolescents with BPD.

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