Altered coordination of the neuroendocrine response during psychosocial stress in subjects with high trait anxiety

Dunčko, Roman; Makatsori, Aikaterini; Ficková, Emília; Selko, Dusan; Ježová, Daniela

doi:10.1016/j.pnpbp.2006.04.002

Cited by 50 publications

(37 citation statements)

References 43 publications

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“…On the other hand, inadequate cortisol responses may occur in response to huge stress stimuli activating several hormonal systems such as insulin-induced hypoglycemia used in the present study. This suggestion is supported by our previous observation of blunted plasma and salivary cortisol responses to an intensive psychosocial stress paradigm in subjects with high trait anxiety [32,33]. Actually, a relatively low activation of the HPA axis with respect to concomitant changes in subjective anxiety has been repeatedly observed in patients with panic disorder, particularly in response to panicogenic agents [11].…”

Section: Discussionsupporting

confidence: 58%

Attenuated Neuroendocrine Response to Hypoglycemic Stress in Patients with Panic Disorder

Ježová¹,

Vigaŝ

Hlavacova³

et al. 2010

Neuroendocrinology

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Background/Aims: There is a lack of information on the effects of metabolic stress exposure on hormone release in patients with panic disorder. The aim of this study was to test the hypothesis that neuroendocrine activation during hypoglycemic stress is altered in panic disorder patients compared to healthy subjects. Methods: Hormone responses to an intravenous bolus of insulin (0.1 IU/kg) were evaluated in both fully remitted, medication-free panic disorder patients and healthy controls (n = 9/group). Blood samples for determination of cortisol, growth hormone, prolactin, adrenaline and noradrenaline concentrations were obtained at rest and over a 90-min period after insulin injection. Results: In patients with panic disorder, basal prestress hormone levels were comparable to those in healthy subjects with the exception of plasma adrenaline, which was higher in panic disorder patients compared to controls. The degree of hypoglycemia induced by insulin administration was similar in patients and healthy subjects. Hypoglycemia-induced increases in growth hormone, prolactin and cortisol concentrations were significantly attenuated in panic disorder patients compared to healthy individuals. No differences between patients and controls were observed in adrenalin release induced by hypoglycemia. Conclusions: The present data demonstrate that somatotropic, lactotropic and corticotropic activation during hypoglycemic stress is blunted in patients with panic disorder. It is suggested that in contrast to the effects of relatively mild stress conditions used in other studies published in the literature, intensive stressors inducing a broad spectrum of hormonal changes fail to provoke an adequate neuroendocrine response in patients with panic disorder.

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Section: Discussionsupporting

confidence: 58%

Attenuated Neuroendocrine Response to Hypoglycemic Stress in Patients with Panic Disorder

Ježová¹,

Vigaŝ

Hlavacova³

et al. 2010

Neuroendocrinology

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“…A high basal cortisol and an increased basal sympathetic tone lead to psychological pathologies and blunt normal responsiveness of both the hypothalamo-pituitary-adrenal and the sympathetic axes to stress exposure (4,6,10,12,43) as seen in clinical anxiety (6). Thus, we postulate that the reduction of basal cortisol and chromogranin-A by Lys/Arg contributed to a lower anxiety and to an improved responsiveness of both axes to acute mental stress in the Lys/Arg-treated males, as attested by the stressspecific responses of cortisol and chromogranin-A.…”

Section: Discussionmentioning

confidence: 99%

Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans

et al. 2007

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Dietary supplementation with an essential amino acid L-lysine has been shown to reduce chronic anxiety in humans with low dietary intake of L-lysine. A combination of L-lysine and L-arginine has been documented to normalize hormonal stress responses in humans with high trait anxiety. The present study was carried out in one hundred eight healthy Japanese adults. The aim of study was to find out whether a week-long oral treatment with L-lysine (2.64 g per day) and L-arginine (2.64 g per day) reduces trait and stress-induced state anxiety and basal levels of stress hormones. We confirmed that, without regard to gender, the amino acid treatment significantly reduced both trait anxiety and state anxiety induced by cognitive stress battery. In addition, we found that the treatment with L-lysine and L-arginine decreased the basal levels of salivary cortisol and chromogranin-A (a salivary marker of the sympatho-adrenal system) in male subjects. These results of this double-blind, placebo controlled and randomized study confirm the previous findings in humans and animals and point to a combination of L-lysine and L-arginine as a potentially useful dietary intervention in otherwise healthy humans with high subjective levels of mental stress and anxiety.

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“…In contrast to the original description of the stress response as generalized and uniform (Selye 1975), it is now viewed as more complex and variable, depending on the nature of the stressor and the current status of the stressed subject (Kopin 1995;Pacak and Palkovits 2001;Duncko et al 2006). The main organ systems involved in these physiological responses are the sympathetic autonomic system (SAS) and the hypothalamic-pituitaryadrenocortical (HPA) axis.…”

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confidence: 99%

Acute exposure to stress improves performance in trace eyeblink conditioning and spatial learning tasks in healthy men

Dunčko¹,

Cornwell²,

Cui³

et al. 2007

Learn. Mem.

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The present study investigated the effects of acute stress exposure on learning performance in humans using analogs of two paradigms frequently used in animals. Healthy male participants were exposed to the cold pressor test (CPT) procedure, i.e., insertion of the dominant hand into ice water for 60 sec. Following the CPT or the control procedure, participants completed a trace eyeblink conditioning task followed by a virtual navigation Morris water task (VNMWT). Hypothalamic-pituitary-adrenocortical (HPA) axis and sympathetic autonomic system (SAS) activity were assessed by measuring salivary cortisol, heart rate, and skin conductance at selected timepoints. Results revealed positive effects of stress on performance in both tasks. The stress group showed significantly more conditioned blinks than the control group during acquisition of trace eyeblink conditioning. The stress group also performed significantly better in the VNMWT than the control group, with the former showing significantly fewer failures to locate the hidden platform in the allotted time and smaller heading errors than the latter. Regression analyses revealed positive relationships between HPA axis and SAS activity during stress and eyeblink conditioning performance. Our results directly extend findings from animal studies and suggest potential physiological mechanisms underlying stress and learning.

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Altered coordination of the neuroendocrine response during psychosocial stress in subjects with high trait anxiety

Cited by 50 publications

References 43 publications

Attenuated Neuroendocrine Response to Hypoglycemic Stress in Patients with Panic Disorder

Attenuated Neuroendocrine Response to Hypoglycemic Stress in Patients with Panic Disorder

Oral treatment with L-lysine and L-arginine reduces anxiety and basal cortisol levels in healthy humans

Acute exposure to stress improves performance in trace eyeblink conditioning and spatial learning tasks in healthy men

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