Altered cerebellar and caudate gray‐matter volumes and structural covariance networks preceding dual cognitive and mobility impairments in older people
Pei‐Lin Lee,
Kun‐Hsien Chou,
Wei‐Ju Lee
et al.
Abstract:INTRODUCTIONThe neuroanatomical changes driving both cognitive and mobility impairments, an emerging preclinical dementia syndrome, are not fully understood. We examined gray‐matter volumes (GMVs) and structural covariance networks (SCNs) abnormalities in community‐based older people preceding the conversion to physio‐cognitive decline syndrome (PCDS).METHODSVoxel‐wise brain GMV and established SCNs were compared between PCDS and non‐PCDS converters.RESULTSThe study included 343 individuals (60.2 ± 6.9 years, … Show more
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