Altered Caveolin-1 Dynamics Result in Divergent Mineralization Responses in Bone and Vascular Calcification

Bakhshian Nik, Amirala; Kaiser, Katherine; Sun, Patrick; Khomtchouk, Bohdan B.; Hutcheson, Joshua D.

doi:10.1007/s12195-023-00779-7

Cited by 1 publication

(1 citation statement)

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“…The calcification observed in the pulp may be comparable to the "calcification paradox", which often refers to the paradoxical phenomenon of the simultaneous occurrence of vascular calcification and osteoporosis [55]. Research on the calcification paradox is currently limited, and there is insufficient evidence to support the notion that macrophages [56], various extracellular vesicles [55], caveolin-1 [57], vitamin K2 [58], and other factors play distinct roles in different anatomical sites. According to our research findings, which indicate the significant contribution of sensory nerves in maintaining pulp homeostasis and the distinct phenotypes observed in pulp with the bone following sensory denervation, it is plausible to propose that sensory nerves may have a role in the perplexing phenomenon of "calcification paradox", either through direct or indirect involvement.…”

Section: Discussionmentioning

confidence: 99%

The Role of Sensory Nerves in Dental Pulp Homeostasis: Histological Changes and Cellular Consequences after Sensory Denervation

Wang,

Liu,

Zhou

et al. 2024

IJMS

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Homeostatic maintenance is essential for pulp function. Disrupting pulp homeostasis may lead to pulp degeneration, such as fibrosis and calcifications. Sensory nerves constitute a crucial component of the dental pulp. However, the precise involvement of sensory nerves in pulp homeostasis remains uncertain. In this study, we observed the short-term and long-term histological changes in the dental pulp after inferior alveolar nerve transection. Additionally, we cultured primary dental pulp cells (DPCs) from the innervated and denervated groups and compared indicators of cellular senescence and cellular function. The results revealed that pulp fibrosis occurred at 2 w after the operation. Furthermore, the pulp area, as well as the height and width of the pulp cavity, showed accelerated reductions after sensory denervation. Notably, the pulp area at 16 w after the operation was comparable to that of 56 w old rats. Sensory denervation induced excessive extracellular matrix (ECM) deposition and increased predisposition to mineralization. Furthermore, sensory denervation promoted the senescence of DPCs. Denervated DPCs exhibited decelerated cell proliferation, arrest in the G2/M phase of the cell cycle, imbalance in the synthesis and degradation of ECM, and enhanced mineralization. These findings indicate that sensory nerves play an essential role in pulp homeostasis maintenance and dental pulp cell fate decisions, which may provide novel insights into the prevention of pulp degeneration.

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