Altered brain rhythms and functional network disruptions involved in patients with generalized fixation-off epilepsy

Solana, Ana Beatriz; Martínez, Kenia; Hernández-Tamames, Juan Antonio; Antonio‐Arce, Victoria San; Toledano, Rafael; García‐Morales, Irene; Álvarez‐Linera, Juan; Gil‐Nagel, Antonio; Pozo, Francisco del

doi:10.1007/s11682-015-9404-6

Cited by 8 publications

(2 citation statements)

References 35 publications

(62 reference statements)

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“…8 Altered brain rhythms through different networks in generalized FOS appear to be associated with impaired spontaneous brain activity. 25 In this study, impairment in frontal tasks was observed in the neuropsychometric evaluation of two patients with posterior lesions; this result is indicative of a complex network disorder. This abnormal pattern may also be important for understanding the physiology of visual and perceptual systems.…”

Section: Discussionmentioning

confidence: 51%

Electroclinical Presentations of Fixation-off Sensitivity in Adults With Symptomatic Epilepsy

Pektezel

Tezer

Saygı

2021

Journal of Clinical Neurophysiology

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Purpose: Fixation-off sensitivity (FOS) is a discharge pattern on EEG that occurs owing to the loss of central vision or fixation. Knowledge regarding the relationship between FOS and symptomatic epilepsy is limited. Therefore, we aimed to evaluate the electroclinical features of FOS in adult patients with symptomatic epilepsy.Methods: Outpatient video-EEG records of the Hacettepe University Faculty of Medicine were reviewed from 2009 to 2019. Patients aged .18 years with symptomatic epilepsy with a FOS pattern were included. Demographic, clinical, EEG, and neuroimaging data were retrospectively evaluated from an electronic database and patient files.Results: Eight patients (50% female) were included in this study; seven (87%) had refractory epilepsy. Prominent risk factors were family history of epilepsy in five patients and prenatal/natal insult in four patients. Notable MRI signs included cortical developmental malformation, posterior gliosis, and frontoparietal porencephalic cyst.The FOS pattern was generalized with posterior emphasis in two patients and lateralized or localized in six patients: frontocentroparietal (n ¼ 1) and temporoparietooccipital (n ¼ 5). Fixation-off sensitivity discharges were found to be increased by hyperventilation and decreased by drowsiness and sleep in 50% of patients. Fixation-off sensitivity disappeared in one patient with good seizure control.Conclusions: In this study, the disappearance of FOS in an epileptic patient with a structural lesion and detection of FOS activity related to a frontoparietal porencephalic cyst were remarkable. Family history of epilepsy was also substantially high. Our results indicate that the underlying mechanism of FOS is much more complicated than previously thought.

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Section: Discussionmentioning

confidence: 51%

Electroclinical Presentations of Fixation-off Sensitivity in Adults With Symptomatic Epilepsy

Pektezel

Tezer

Saygı

2021

Journal of Clinical Neurophysiology

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“…The common approach to EEG classification is based on the analysis in frequency bands, that are proven to be related to various types of mental and physical conditions [40,49]. For example, delta waves (2-4 Hz) are related to consciousness and attention, theta (4-7 Hz) and alpha (8)(9)(10)(11)(12)(13)(14)(15) Hz) reflect thinking, focus, and attention.…”

Section: Eeg Signal Processing Approachesmentioning

confidence: 99%

Real and imaginary motion classification based on rough set analysis of EEG signals for multimedia applications

Szczuko

2017

Multimed Tools Appl

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Rough set-based approach to the classification of EEG signals of real and imaginary motion is presented. The pre-processing and signal parametrization procedures are described, the rough set theory is briefly introduced, and several classification scenarios and parameters selection methods are proposed. Classification results are provided and discussed with their potential utilization for multimedia applications controlled by the motion intent. Accuracy metrics of classification for real and imaginary motion obtained with different parameter sets are compared. Results of experiments employing recorded EEG signals are commented and further research directions are proposed.

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Comparison of Methods for Real and Imaginary Motion Classification from EEG Signals

Szczuko

Lech

Czyżewski

2018

Studies in Big Data

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Altered brain rhythms and functional network disruptions involved in patients with generalized fixation-off epilepsy

Cited by 8 publications

References 35 publications

Electroclinical Presentations of Fixation-off Sensitivity in Adults With Symptomatic Epilepsy

Electroclinical Presentations of Fixation-off Sensitivity in Adults With Symptomatic Epilepsy

Real and imaginary motion classification based on rough set analysis of EEG signals for multimedia applications

Comparison of Methods for Real and Imaginary Motion Classification from EEG Signals

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