Altered brain neurotrophins at birth: consequence of imbalance in maternal folic acid and vitamin B12 metabolism

Sable, Pratiksha; Dangat, Kamini; Kale, Anvita; Joshi, Sadhana

doi:10.1016/j.neuroscience.2011.05.010

Cited by 49 publications

(33 citation statements)

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“…The results presented here show that the expression of memory-and-learning-related genes is in phase with daily patterns of key molecular clock factors, however, such temporal organization would be susceptible to the nutritional vitamin A deficiency. Even though, it has been reported vitamin A, as well as other vitamin deficiencies, reduce BDNF and RC3 expression in the hippocampus (Husson et al, 2004, Sable et al, 2011), no study describes the consequences of nutritional deficiencies on temporal profiles of synaptic-plasticity-related genes. Here, we observed BDNF and RC3 oscillating expression was phase shifted and, in the case of BDNF, also attenuated, in the hippocampus of vitamin A-deficient rats.…”

Section: Discussionmentioning

confidence: 99%

Daily patterns of clock and cognition‐related factors are modified in the hippocampus of vitamin A‐deficient rats

et al. 2012

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The circadian expression of clock and clock-controlled cognition-related genes in the hippocampus would be essential to achieve an optimal daily cognitive performance. There is some evidence that retinoid nuclear receptors (RARs and RXRs) can regulate circadian gene expression in different tissues. In this study, Holtzman male rats from control and vitamin A-deficient groups were sacrificed throughout a 24-h period and hippocampus samples were isolated every 4 or 5 h. RARα and RXRβ expression level was quantified and daily expression patterns of clock BMAL1, PER1, RORα and REVERB genes, RORα and REVERB proteins, as well as temporal expression of cognition-related RC3 and BDNF genes were determined in the hippocampus of the two groups of rats. Our results show significant daily variations of BMAL1, PER1, RORα and REVERB genes, RORα and REVERB proteins and, consequently, daily oscillating expression of RC3 and BDNF genes in the rat hippocampus. Vitamin A deficiency reduced RXRβ mRNA level as well as the amplitude of PER1, REVERB gene and REVERB protein rhythms, and phase-shifted the daily peaks of BMAL1 and RORα mRNA, RORα protein and RC3 and BDNF mRNA levels. Thus, nutritional factors, such as vitamin A and its derivatives the retinoids, might modulate daily patterns of BDNF and RC3 expression in the hippocampus and they could be essential to maintain an optimal daily performance at molecular level in this learning-and-memory-related brain area.

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Section: Discussionmentioning

confidence: 99%

Daily patterns of clock and cognition‐related factors are modified in the hippocampus of vitamin A‐deficient rats

et al. 2012

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“…The detailed description of the animal protocol has been published by us earlier [12–15]. The animals were bred at 3 months of age, till which they were fed control diet.…”

Section: Methodsmentioning

confidence: 99%

Expression of Genes Encoding Enzymes Involved in the One Carbon Cycle in Rat Placenta is Determined by Maternal Micronutrients (Folic Acid, Vitamin B₁₂) and Omega-3 Fatty Acids

Khot

Kale

Joshi

et al. 2014

BioMed Research International

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We have reported that folic acid, vitamin B12, and omega-3 fatty acids are interlinked in the one carbon cycle and have implications for fetal programming. Our earlier studies demonstrate that an imbalance in maternal micronutrients influence long chain polyunsaturated fatty acid metabolism and global methylation in rat placenta. We hypothesize that these changes are mediated through micronutrient dependent regulation of enzymes in one carbon cycle. Pregnant dams were assigned to six dietary groups with varying folic acid and vitamin B12 levels. Vitamin B12 deficient groups were supplemented with omega-3 fatty acid. Placental mRNA levels of enzymes, levels of phospholipids, and glutathione were determined. Results suggest that maternal micronutrient imbalance (excess folic acid with vitamin B12 deficiency) leads to lower mRNA levels of methylene tetrahydrofolate reductase (MTHFR) and methionine synthase , but higher cystathionine b-synthase (CBS) and Phosphatidylethanolamine-N-methyltransferase (PEMT) as compared to control. Omega-3 supplementation normalized CBS and MTHFR mRNA levels. Increased placental phosphatidylethanolamine (PE), phosphatidylcholine (PC), in the same group was also observed. Our data suggests that adverse effects of a maternal micronutrient imbalanced diet may be due to differential regulation of key genes encoding enzymes in one carbon cycle and omega-3 supplementation may ameliorate most of these changes.

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“…Studies have confirmed BDNF as being implicated in a wide spectrum of neurological and neurodegenerative diseases, such as mood disorders and neurological disorders (Autry and Monteggia, 2012;Balaratnasingam and Janca, 2012;Boulle et al, 2012;Duman, 2004;Lu et al, 2013). Furthermore, it has been shown in rodent models that BDNF expression is sensitive to early environmental challenges and is reduced by a variety of adverse influences known to be risk factors for neurodevelopmental disorders such as maternal nutrient deficiency (Sable et al, 2011(Sable et al, , 2014, prenatal alcohol exposure (Caldwell et al, 2008;Feng et al, 2005;Maier et al, 1999) and early life stress (Roceri et al, 2002).…”

Section: Bdnf As Therapeuticmentioning

confidence: 98%

7,8-Dihydroxyflavone as a pro-neurotrophic treatment for neurodevelopmental disorders

Hill

2015

Neurochemistry International

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Altered brain neurotrophins at birth: consequence of imbalance in maternal folic acid and vitamin B12 metabolism

Cited by 49 publications

References 50 publications

Daily patterns of clock and cognition‐related factors are modified in the hippocampus of vitamin A‐deficient rats

Daily patterns of clock and cognition‐related factors are modified in the hippocampus of vitamin A‐deficient rats

Expression of Genes Encoding Enzymes Involved in the One Carbon Cycle in Rat Placenta is Determined by Maternal Micronutrients (Folic Acid, Vitamin B₁₂) and Omega-3 Fatty Acids

7,8-Dihydroxyflavone as a pro-neurotrophic treatment for neurodevelopmental disorders

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Altered brain neurotrophins at birth: consequence of imbalance in maternal folic acid and vitamin B12 metabolism

Cited by 49 publications

References 50 publications

Daily patterns of clock and cognition‐related factors are modified in the hippocampus of vitamin A‐deficient rats

Daily patterns of clock and cognition‐related factors are modified in the hippocampus of vitamin A‐deficient rats

Expression of Genes Encoding Enzymes Involved in the One Carbon Cycle in Rat Placenta is Determined by Maternal Micronutrients (Folic Acid, Vitamin B12) and Omega-3 Fatty Acids

7,8-Dihydroxyflavone as a pro-neurotrophic treatment for neurodevelopmental disorders

Contact Info

Product

Resources

About

Expression of Genes Encoding Enzymes Involved in the One Carbon Cycle in Rat Placenta is Determined by Maternal Micronutrients (Folic Acid, Vitamin B₁₂) and Omega-3 Fatty Acids