Altered Brain Network Dynamics in Schizophrenia: A Cognitive Electroencephalography Study

Naim-Feil, Jodie; Rubinson, Mica; Freche, Dominik; Grinshpoon, Alexander; Peled, Alva; Moses, Elisha; Levit‐Binnun, Nava

doi:10.1016/j.bpsc.2017.03.017

Cited by 23 publications

(15 citation statements)

References 54 publications

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“…74 New advances in temporal network construction utilizing neuroimaging techniques with higher temporal resolution (ie, electroencephalography/magnetoencephalography) are therefore of interest to reveal dynamic reconfiguration of networks in prominent cognitive disturbance in schizophrenia at fine timescale. 73,75 Finally, to increase the credibility of the current work, we used 2 independent datasets and mainly focused on the interpretation of the comparable findings. Although this is an advantage of the study, the included patients subsequently have different scanning settings and heterogeneous clinical characteristics.…”

Section: Discussionmentioning

confidence: 99%

Dynamic Reorganization of Functional Connectivity Reveals Abnormal Temporal Efficiency in Schizophrenia

Sun

Collinson

Suckling

et al. 2018

Schizophrenia Bulletin

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Emerging evidence suggests that schizophrenia is associated with brain dysconnectivity. Nonetheless, the implicit assumption of stationary functional connectivity (FC) adopted in most previous resting-state functional magnetic resonance imaging (fMRI) studies raises an open question of schizophrenia-related aberrations in dynamic properties of resting-state FC. This study introduces an empirical method to examine the dynamic functional dysconnectivity in patients with schizophrenia. Temporal brain networks were estimated from resting-state fMRI of 2 independent datasets (patients/controls = 18/19 and 53/57 for self-recorded dataset and a publicly available replication dataset, respectively) by the correlation of sliding time-windowed time courses among regions of a predefined atlas. Through the newly introduced temporal efficiency approach and temporal random network models, we examined, for the first time, the 3D spatiotemporal architecture of the temporal brain network. We found that although prominent temporal small-world properties were revealed in both groups, temporal brain networks of patients with schizophrenia in both datasets showed a significantly higher temporal global efficiency, which cannot be simply attributable to head motion and sampling error. Specifically, we found localized changes of temporal nodal properties in the left frontal, right medial parietal, and subcortical areas that were associated with clinical features of schizophrenia. Our findings demonstrate that altered dynamic FC may underlie abnormal brain function and clinical symptoms observed in schizophrenia. Moreover, we provide new evidence to extend the dysconnectivity hypothesis in schizophrenia from static to dynamic brain network and highlight the potential of aberrant brain dynamic FC in unraveling the pathophysiologic mechanisms of the disease.

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Section: Discussionmentioning

confidence: 99%

Dynamic Reorganization of Functional Connectivity Reveals Abnormal Temporal Efficiency in Schizophrenia

Sun

Collinson

Suckling

et al. 2018

Schizophrenia Bulletin

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“…One possible next step in this line of EEG research, aimed at better understanding the neurophysiological mechanisms contributing to atypical ERP responses to others’ pain in schizophrenia, is to examine patterns of whole‐brain functional connectivity, across low‐ and high‐frequency bands, within the context of an empathy for pain paradigm. This is particularly warranted considering (1) current imaging evidence (particularly from fMRI studies) implicates a complex network of dissociable, yet interdependent neural regions, in the affective and cognitive aspects of empathic processing (Abu‐Akel & Shamay‐Tsoory, ; Bernhardt & Singer, ), (2) global, network functional coordination underlies almost all cognitive function (Dehaene & Changeux, ; Varela, Lachaux, Rodriguez, & Martinerie, ) and the high temporal specificity of EEG allows for examination of the dynamics of this coordination, (3) there is increasing evidence demonstrating the influence of background oscillatory dynamics on ERPs (Karakaş, Erzengin, & Başar, ; Li et al ., ; Schneider & Maguire, ), and (4) there is a large body of evidence from EEG studies demonstrating atypical oscillatory, and functional connectivity, patterns in schizophrenia across multiple frequency bands that underlie cognitive processing (Gonzalez‐Burgos, Cho, & Lewis, ; McNally & McCarley, ; Naim‐Feil et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Empathy for others’ pain is disrupted at the neurophysiological level in schizophrenia

Varcin

Grainger

Bailey

et al. 2019

British J Clinic Psychol

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Objective. Previous research has shown that empathy for pain is disrupted at the neural level in people with schizophrenia. However, many of these studies have failed to assess key background contextual variables that have previously been linked to neurophysiological responding. Moreover, no study to date has examined the potential influence of schizotypal characteristics on neurophysiological responding in non-clinical individuals.Methods. People with schizophrenia (N = 17) were compared to demographically matched controls (N = 19) on an event-related potential (ERP) empathy for pain paradigm. The control group also completed a measure of schizotypal personality traits.Results. People with schizophrenia exhibited atypical neural responding at early, emotion-sharing (frontal N110), and late, cognitive (central late positive potential [LPP]) processing stages of pain empathy, relative to controls. In the control group, positive schizotypy traits were significantly negatively related to reduced ERP amplitude in the late, cognitive (central LPP) processing stage of empathy.Conclusions. These data cross-validate previous studies that have shown that schizophrenia is associated with atypicalities in bottom-up automatic resonance processes that likely contribute to empathic and socio-emotional processing deficits, and indicate that these findings cannot be easily attributed to background contextual differences between the two groups. The results also point to a potential relationship between positive schizotypal characteristics and neurophysiological responding. Implications for simulation theories of empathy and social functioning in schizophrenia are discussed. Practitioner pointsEmpathic processing has been consistently linked to well-being and mental health in many groups, including people with schizophrenia.

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“…Schizophrenia is associated with an alteration in brain structure and function (Naim‐Feil et al . ), and antipsychotic medication can have a positive impact on both these aspects (Hutcheson et al . ).…”

Section: Discussionmentioning

confidence: 99%

An international survey of Psychiatric‐Mental‐Health Nurses on the content validity of the International Classification of Functioning, Disability and Health Core Sets for Schizophrenia

Nuño

Barrios

Moller

et al. 2019

Int J Mental Health Nurs

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The International Classification of Functioning, Disability and Health (ICF) Core Sets for schizophrenia describe the key problems in functioning that are experienced by individuals with this disorder. This study examines the content validity of these Core Sets and aims to identify the most frequent problems faced by people with schizophrenia, considering for this analysis the perspective of Psychiatric-Mental-Health Nurses. The study complied with the COREQ checklist for qualitative studies. A total of 101 nurses from 30 countries covering all six World Health Organization regions participated in a Delphi study. Their responses in Round 1 were linked to ICF categories, retaining those reported by at least 5% of participants. In Round 2, they were asked to rate the relevance of each of these categories to the nursing care of patients with schizophrenia. This process was repeated in Round 3. A total of 2327 concepts were extracted in Round 1 and linked to ICF categories. Following the analysis, 125 categories and 31 personal factors were presented to the experts in rounds 2 and 3. Consensus (defined as agreement ≥75%) was reached for 97 of these categories and 29 personal factors. These categories corresponded to all those (N = 25) in the Brief Core Set and 87 of the 97 categories of the bs_bs_banner Comprehensive Core Set for schizophrenia. Ten new categories emerged. The Delphi process identified the problems in functioning that nurses encounter when treating individuals with schizophrenia, and the results supported the content validity of the Core Sets. We conclude that these Core Sets offer a comprehensive framework for structuring clinical information and guiding the treatment process.

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Altered Brain Network Dynamics in Schizophrenia: A Cognitive Electroencephalography Study

Cited by 23 publications

References 54 publications

Dynamic Reorganization of Functional Connectivity Reveals Abnormal Temporal Efficiency in Schizophrenia

Dynamic Reorganization of Functional Connectivity Reveals Abnormal Temporal Efficiency in Schizophrenia

Empathy for others’ pain is disrupted at the neurophysiological level in schizophrenia

An international survey of Psychiatric‐Mental‐Health Nurses on the content validity of the International Classification of Functioning, Disability and Health Core Sets for Schizophrenia

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