Altered Blood Proteome in Girls with High Urine Concentrations of Bisphenol A, Genistein, Mono-Ethyl Hexylphthalate and Mono-Benzyl Phthalate

Wang, Jun; Betancourt, Angela M.; Jenkins, Sarah; Biro, Frank M.; Pinney, Susan M.; Chen, Dongquan; Russo, José; Lamartiniere, Coral A.

doi:10.15406/mojpb.2015.02.00040

Cited by 6 publications

(5 citation statements)

References 60 publications

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“…A cross-sectional study by Wang et al [85] may provide the basis for such a study. These authors found that cancer-related proteins in the circulation were favorably altered in girls excreting large amounts of genistein and small amounts of bisphenol A (BPA) when compared to girls excreting small amounts of genistein and large amounts of BPA [85]. In rodents, these changes reflect decreases and increases in cancer risk, respectively [86,87].…”

Section: Discussionmentioning

confidence: 99%

Impact of Soy Foods on the Development of Breast Cancer and the Prognosis of Breast Cancer Patients

Messina

2016

Complement Med Res

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The relationship between soy food intake and breast cancer has been rigorously investigated for more than 25 years. The identification of isoflavones as possible chemopreventive agents helped fuel this line of investigation. These diphenolic compounds, which are found in uniquely-rich amounts in soy beans, possess both estrogen-dependent and -independent properties that potentially inhibit the development of breast cancer. Observational studies show that among Asian women higher soy consumption is associated with an approximate 30% reduction in risk of developing breast cancer. However, evidence suggests that for soy to reduce breast cancer risk consumption must occur early in life, that is during childhood and/or adolescence. Despite the interest in the role of soy in reducing breast cancer risk concerns have arisen that soy foods, because they contain isoflavones, may increase the likelihood of high-risk women developing breast cancer and worsen the prognosis of breast cancer patients. However, extensive clinical and epidemiologic data show these concerns to be unfounded. Clinical trials consistently show that isoflavone intake does not adversely affect markers of breast cancer risk, including mammographic density and cell proliferation. Furthermore, prospective epidemiologic studies involving over 11,000 women from the USA and China show that postdiagnosis soy intake statistically significantly reduces recurrence and improves survival.

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Section: Discussionmentioning

confidence: 99%

Impact of Soy Foods on the Development of Breast Cancer and the Prognosis of Breast Cancer Patients

Messina

2016

Complement Med Res

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“…Omics: transcriptomics [119][120][121], exposomics and epigenomics [122,123], blood proteomics [124], organoid proteomics [125], metabolomics [126] Postmenopausal HRT/oral contraceptives/ hormone treatment/ endocrine therapy increase of 20-30% in BCR associated with current or recent use of either oral combined or progestagen-only contraceptives [127] increases epithelial proliferation in postmenopausal TDLUs [128] benign breast biopsies [128] IHC, comparative breast epithelial density [128] Bisphenols (BPA, BPAF, BPF, BPS) increased BCR in mice [129] BC cell growth, proliferation and migration, activation of signal transduction pathways (STAT3, PI3K/AKT, GPER/EGFR/ERK1/2; MEK/ERK), epigenetic silencing of tumor suppressor genes, apoptosis, OS, glucose metabolism, angiogenesis, resistance to endocrine therapy [119,122,130]; in utero BPA exposure alters the stroma to increase ECM density and mammary gland stiffness [120]; BPA alter the proteolysis and isoform expression by alternative splicing [125] hBC cell lines, animal models, clinical studies, human blood samples, mouse mammary organoids [119,124,125] RT-qPCR, ChIP-qPCR [119], TMT-MS [124], LC-MS/MS [125], RNA-seq profiling of adult primary fibroblasts, SHIM and collagen fiber analysis [120] Diethylstilbestrol (DES) increased BCR in pregnant women, daughters, and granddaughters [123,131] deregulation of mammary gland differentiation and development-related genes may be induced and cause the increased number of TDLUs in human mammary glands [132]; epigenetic alterations: increased DNA methylation, modification in histones and miRNA expression [123] animal models/tissue samples [132] RT-qPCR, IF [132] Phthalates (MEHP, MBzP, DEHP, DBP) and phthalates substitutes (ATBC)…”

Section: Exogenous Hormones and Edcsmentioning

confidence: 99%

“…PT [126], high-level DBP exposure associated with 2-fold increase in the rate of ER + -BC [133] ATBC may be involved in cell proliferation [126]; promotes BC cells growth through ER signaling [133] human plasma samples [126], mice mammary organoid cultures [125], cohort studies [133,134] TMT-MS [124], LC-MS [126] Table 1. Cont.…”

Section: Exogenous Hormones and Edcsmentioning

confidence: 99%

Onco-Breastomics: An Eco-Evo-Devo Holistic Approach

Neagu,

Whitham,

Bruno

et al. 2024

IJMS

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Known as a diverse collection of neoplastic diseases, breast cancer (BC) can be hyperbolically characterized as a dynamic pseudo-organ, a living organism able to build a complex, open, hierarchically organized, self-sustainable, and self-renewable tumor system, a population, a species, a local community, a biocenosis, or an evolving dynamical ecosystem (i.e., immune or metabolic ecosystem) that emphasizes both developmental continuity and spatio-temporal change. Moreover, a cancer cell community, also known as an oncobiota, has been described as non-sexually reproducing species, as well as a migratory or invasive species that expresses intelligent behavior, or an endangered or parasite species that fights to survive, to optimize its features inside the host’s ecosystem, or that is able to exploit or to disrupt its host circadian cycle for improving the own proliferation and spreading. BC tumorigenesis has also been compared with the early embryo and placenta development that may suggest new strategies for research and therapy. Furthermore, BC has also been characterized as an environmental disease or as an ecological disorder. Many mechanisms of cancer progression have been explained by principles of ecology, developmental biology, and evolutionary paradigms. Many authors have discussed ecological, developmental, and evolutionary strategies for more successful anti-cancer therapies, or for understanding the ecological, developmental, and evolutionary bases of BC exploitable vulnerabilities. Herein, we used the integrated framework of three well known ecological theories: the Bronfenbrenner’s theory of human development, the Vannote’s River Continuum Concept (RCC), and the Ecological Evolutionary Developmental Biology (Eco-Evo-Devo) theory, to explain and understand several eco-evo-devo-based principles that govern BC progression. Multi-omics fields, taken together as onco-breastomics, offer better opportunities to integrate, analyze, and interpret large amounts of complex heterogeneous data, such as various and big-omics data obtained by multiple investigative modalities, for understanding the eco-evo-devo-based principles that drive BC progression and treatment. These integrative eco-evo-devo theories can help clinicians better diagnose and treat BC, for example, by using non-invasive biomarkers in liquid-biopsies that have emerged from integrated omics-based data that accurately reflect the biomolecular landscape of the primary tumor in order to avoid mutilating preventive surgery, like bilateral mastectomy. From the perspective of preventive, personalized, and participatory medicine, these hypotheses may help patients to think about this disease as a process governed by natural rules, to understand the possible causes of the disease, and to gain control on their own health.

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“…Using the search term "proteomics and endocrine disrupters" on PubMed results in only 57 publications (as of February 2020). Further analysis of the results reveals as few as 7 studies related to primary research focused on human studies [38][39][40][41][42][43][44]. Of the limited number of thyroid proteomic studies, a large proportion is focused on describing the differences between the proteomes of normal vs. neoplastic thyroid tissue.…”

Section: State Of the Art On Proteomics For Investigation Of The Thyroid Tissuementioning

confidence: 99%

SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner

Moroni

Barbaro

Caiment

et al. 2020

IJMS

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Endocrine disruptors (EDs) are chemicals that contribute to health problems by interfering with the physiological production and target effects of hormones, with proven impacts on a number of endocrine systems including the thyroid gland. Exposure to EDs has also been associated with impairment of the reproductive system and incidence in occurrence of obesity, type 2 diabetes, and cardiovascular diseases during ageing. SCREENED aims at developing in vitro assays based on rodent and human thyroid cells organized in three different three-dimensional (3D) constructs. Due to different levels of anatomical complexity, each of these constructs has the potential to increasingly mimic the structure and function of the native thyroid gland, ultimately achieving relevant features of its 3D organization including: (1) a 3D organoid based on stem cell-derived thyrocytes, (2) a 3D organoid based on a decellularized thyroid lobe stromal matrix repopulated with stem cell-derived thyrocytes, and (3) a bioprinted organoid based on stem cell-derived thyrocytes able to mimic the spatial and geometrical features of a native thyroid gland. These 3D constructs will be hosted in a modular microbioreactor equipped with innovative sensing technology and enabling precise control of cell culture conditions. New superparamagnetic biocompatible and biomimetic particles will be used to produce “magnetic cells” to support precise spatiotemporal homing of the cells in the 3D decellularized and bioprinted constructs. Finally, these 3D constructs will be used to screen the effect of EDs on the thyroid function in a unique biological sex-specific manner. Their performance will be assessed individually, in comparison with each other, and against in vivo studies. The resulting 3D assays are expected to yield responses to low doses of different EDs, with sensitivity and specificity higher than that of classical 2D in vitro assays and animal models. Supporting the “Adverse Outcome Pathway” concept, proteogenomic analysis and biological computational modelling of the underlying mode of action of the tested EDs will be pursued to gain a mechanistic understanding of the chain of events from exposure to adverse toxic effects on thyroid function. For future uptake, SCREENED will engage discussion with relevant stakeholder groups, including regulatory bodies and industry, to ensure that the assays will fit with purposes of ED safety assessment. In this project review, we will briefly discuss the current state of the art in cellular assays of EDs and how our project aims at further advancing the field of cellular assays for EDs interfering with the thyroid gland.

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Altered Blood Proteome in Girls with High Urine Concentrations of Bisphenol A, Genistein, Mono-Ethyl Hexylphthalate and Mono-Benzyl Phthalate

Cited by 6 publications

References 60 publications

Impact of Soy Foods on the Development of Breast Cancer and the Prognosis of Breast Cancer Patients

Impact of Soy Foods on the Development of Breast Cancer and the Prognosis of Breast Cancer Patients

Onco-Breastomics: An Eco-Evo-Devo Holistic Approach

SCREENED: A Multistage Model of Thyroid Gland Function for Screening Endocrine-Disrupting Chemicals in a Biologically Sex-Specific Manner

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