Altered blood cytokines, CD4 T cells, NK and neutrophils in patients with obstructive sleep apnea

Said, Elias A.; Abri, Mohammed Al; Al-Saidi, Iman; Al-Balushi, Mohammed S.; Al-Busaidi, Jumaa Z.; Al-Reesi, Iman; Koh, Crystal Y.; Hasson, Sidgi S.; Idris, Mohamed A.; Al-Jabri, Ali A.; Habbal, Omar

doi:10.1016/j.imlet.2017.08.009

Cited by 20 publications

(18 citation statements)

References 35 publications

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“…The highest among these values was 43.5 pg/ml. [9][10][11][12][13][14][15][16][17] F I G U R E 2 Simplified flow chart showing the number of studies. The included studies were 140.…”

Section: Resultsmentioning

confidence: 99%

Defining IL‐6 levels in healthy individuals: A meta‐analysis

Said

Al-Reesi

Al-Shizawi

et al. 2020

Journal of Medical Virology

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Background Interleukin‐6 (IL‐6) is produced by and impacts different cell types in human. IL‐6 is associated with different diseases and viral infections, including COVID‐19. To our knowledge, no normal values were reported for IL‐6 in the blood of healthy individuals. We have reviewed and performed a meta‐analysis on a total of 140 studies, including 12,421 values for IL‐6 in the blood of healthy adult donors. Among these studies, 83 did not report a mean value and the standard deviation. Therefore, for the statistical analysis, we used the values reported in 57 studies, which included 3166 values for IL‐6. Results The reported values for IL‐6 in the blood of healthy donors varied between 0 and 43.5 pg/ml. The pooled estimate of IL‐6 was 5.186 pg/ml (95% confidence interval [CI]: 4.631, 5.740). As the age increased by 1 year, IL‐6 values increased by 0.05 pg/ml (95% CI: 0.02, 0.09; p < .01). Though the heterogenicity, as determined by I2 statistics, was high in our study, the differences in IL‐6 values are still at the level of a few pg/ml, which might be related to the differences in the conditions that influence IL‐6 production in the healthy population. Conclusions This is the first meta‐analysis reporting the levels of IL‐6 in the blood of healthy donors based on a large number of studies and donors. Therefore the 95% CI values determined in our study could well serve as a reference range for quick decision‐making in clinical interventions, particularly those aiming to inhibit IL‐6, especially urgent interventions, for example, COVID‐19.

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“…The highest among these values was 43.5 pg/ml. [9][10][11][12][13][14][15][16][17] F I G U R E 2 Simplified flow chart showing the number of studies. The included studies were 140.…”

Section: Resultsmentioning

confidence: 99%

Defining IL‐6 levels in healthy individuals: A meta‐analysis

Said

Al-Reesi

Al-Shizawi

et al. 2020

Journal of Medical Virology

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“…Another study by Said et al . showed a decreased phagocytotic capacity of neutrophils in OSA patients 22 . Therefore, it seems reasonable to postulate that OSA is likely to facilitate the occurrence of infection or to worsen infection-associated outcomes.…”

Section: Discussionmentioning

confidence: 91%

Impact of Intermittent Hypoxia on Sepsis Outcomes in a Murine Model

Chou

Cheng

Huang

et al. 2019

Sci Rep

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Sleep apnea has been associated with a variety of diseases, but its impact on sepsis outcome remains unclear. This study investigated the effect of intermittent hypoxia [IH]–the principal feature of sleep apnea–on murine sepsis. 5-week-old male C57BL6 mice were assigned to groups receiving severe IH (O2 fluctuating from room air to an O2 nadir of 5.7% with a cycle length of 90 seconds), mild IH (room air to 12%, 4 minutes/cycle), or room air for 3 weeks. Sepsis was induced by cecal ligation and puncture and survival was monitored. Sepsis severity was evaluated by murine sepsis scores, blood bacterial load, plasma tumor necrosis factor-α [TNF-α]/interleukin-6 [IL-6] levels and histopathology of vital organs. Compared with normoxic controls, mice subjected to severe IH had earlier mortality, a lower leukocyte count, higher blood bacterial load, higher plasma TNF-α and IL-6 levels, more severe inflammatory changes in the lung, spleen and small intestine. Mice subjected to mild IH did not differ from normoxic controls, except a higher IL-6 level after sepsis induced. The adverse impact of severe IH was reversed following a 10-day normoxic recovery. In conclusion, severe IH, not mild IH, contributed to poorer outcomes in a murine sepsis model.

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“…Several previous studies demonstrated that OSA may be associated with changes in T-cell activation and proliferation, leading to increased CD4+ and CD8+ cell counts [ 24 , 25 ]. A recent study reported that OSA affected the immune response by increasing the proliferative potential of CD4+ and natural killer cells and decreasing phagocytosis and NADPH oxidase activity in neutrophils [ 26 ]. Similar to those results, we found upregulated type 2 immune inflammation in patients with ECRSwNP and moderate-to-severe OSA.…”

Section: Discussionmentioning

confidence: 99%

Effect of Obstructive Sleep Apnea on Immunity in Cases of Chronic Rhinosinusitis With Nasal Polyps

Kim

Lee

Park

et al. 2021

Clin Exp Otorhinolaryngol

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Objective: Chronic rhinosinusitis (CRS) with nasal polyp (wNP) is a more severe inflammatory form of CRS that often coexists with obstructive sleep apnea (OSA). However, little is known the relationship between OSA and immunologic profile on patients with CRSwNP. We aimed to investigate the immune profile of patients with CRSwNP according to OSA severity.Methods: This study included 63 patients with CRSwNP and nine control subjects. Protein levels of inflammatory mediators were determined using multiplex immunoassay. All patients underwent standard polysomnography.Results: We found that, in patients with eosinophilic CRSwNP (ECRSwNP), IL-6 and CXCL-1 (type 1 immune-related markers) were upregulated in cases of moderate-to-severe OSA. Additionally, IL-4, IL-13, CCL-11, CCL-24 (type 2 immune-related markers), and IL-17A (type 3 immune-related marker) were increased in patients with moderate-to-severe OSA. Though there were no significant differences in type 1, 2, or 3 immune-related markers among patients with non-eosinophilic CRSwNP (NECRSwNP) according to the severity of OSA, TGF-

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Altered blood cytokines, CD4 T cells, NK and neutrophils in patients with obstructive sleep apnea

Cited by 20 publications

References 35 publications

Defining IL‐6 levels in healthy individuals: A meta‐analysis

Defining IL‐6 levels in healthy individuals: A meta‐analysis

Impact of Intermittent Hypoxia on Sepsis Outcomes in a Murine Model

Effect of Obstructive Sleep Apnea on Immunity in Cases of Chronic Rhinosinusitis With Nasal Polyps

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