Altered behaviour in adult mice orally exposed to tri- and tetrachloroethylene as neonates

Fredriksson, Anders; Danielsson, Bengt; Eriksson, Per

doi:10.1016/0378-4274(93)90074-8

Cited by 25 publications

(31 citation statements)

References 21 publications

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“…Because control levels of activity generally fell sharply over the 60-min test, control values for the last 20-min test interval are often not possible to read from the originally published bar graphs; therefore, only data for the first 20-min test interval are shown here. In order to limit experimental variability, the data shown are from studies of compounds that were administered orally in the egg lecithinpeanut oil emulsion vehicle to male NMRI mice on, or starting on, PND10 (Talts et al, 1998;Johansson et al, 1995;Fischer et al, 2008aFischer et al, , 2008bFredriksson et al, 1993aFredriksson et al, , 1993bAhlbom et al, 1994Ahlbom et al, , 1995Eriksson et al, 1990aEriksson et al, , 1990bEriksson et al, , 1992Eriksson et al, , 1993Eriksson et al, , 2001Eriksson et al, , 2002Eriksson et al, , 2006aEriksson et al, , 2006b, 1996Viberg et al, 2002Viberg et al, , 2003aViberg et al, , 2003bViberg et al, , 2006. Data from studies using other species or strains, other routes of exposure, other days of treatment, and other administration vehicles have been excluded from this analysis in order to minimize potential sources of inconsistency.…”

Section: Test Apparatus and Methodologymentioning

confidence: 99%

The Potential of Selected Brominated Flame Retardants to Affect Neurological Development

Williams

DeSesso

2010

Journal of Toxicology and Environmental Health, Part B

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Various brominated flame retardants (BFR), including polybrominated diphenyl ether (PBDE) congeners, hexabromocyclododecane (HBCD), and tetrabromobisphenol A (TBBPA), are commonly used in household items and electronics and have been detected in the environment and/or the bodily fluids of people, including children. Some studies in animals suggest that exposure to PBDE congeners, HBCD, or TBBPA during the perinatal period may affect locomotor activity and/or memory and learning. Epidemiological studies showing similar effects in humans, however, are lacking. To assess whether an association exists between perinatal exposure and development of consistent neurobehavioral alterations, published animal studies investigating perinatal exposure to PBDE congeners, HBCD, or TBBPA with specific neurobehavioral evaluations-particularly, assessments of motor activity-were reviewed for consistency of results. Our analysis shows that although the majority of studies suggest that perinatal exposure affects motor activity, the effects observed were not consistent. This lack of consistency includes the type of motor activity (locomotion, rearing, or total activity) affected, the direction (increase or decrease) and pattern of change associated with exposure, the existence of a dose response, the permanency of findings, and the possibility of gender differences in response. Interestingly, Good Laboratory Practices (GLP)-compliant studies that followed U.S. Environmental Protection Agency (EPA)/Organization for Economic Cooperation and Development (OECD) guidelines for developmental neurotoxicity testing found no adverse effects associated with exposure to PBDE209, HBCD, or TBBPA at doses that were orders of magnitude higher and administered over longer durations than those used in the other studies examined herein. The lack of consistency across studies precludes establishment of a causal relationship between perinatal exposure to these substances and alterations in motor activity.

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Section: Test Apparatus and Methodologymentioning

confidence: 99%

The Potential of Selected Brominated Flame Retardants to Affect Neurological Development

Williams

DeSesso

2010

Journal of Toxicology and Environmental Health, Part B

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“…However, the direction of effect varied. Exposures to halogenated organic compounds ammonium perfluorooctanoate, potassium perfluorooctane sulfonate, and brominated diethyl ethers 992 and 209 (BDE 992, BDE 209) (Eriksson et al, 1999, 2002; Johansson et al, 2008; Viberg et al, 2003, 2001) were associated with decreased or non-significant changes in motor activity levels, while exposure to tetrachloroethylene and DDT was associated with elevated motor activity (Eriksson et al, 1990a, 1990b; Fredriksson et al, 1993; Johansson et al, 1995, 1996). The NOAEL associated with the halogenated organic compounds derived from post-natal exposures occurring outside our derived window, with the exception of BDE 209 exposure to the highest dose (20.1 mg/kg/day versus 2.22 mg/kg/day) at PND 10 (Viberg et al, 2003, 2001).…”

Section: Review Of Toxicological Profilesmentioning

confidence: 99%

Windows of sensitivity to toxic chemicals in the motor effects development

Ingber

Pohl

2016

Regulatory Toxicology and Pharmacology

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Many chemicals currently used are known to elicit nervous system effects. In addition, approximately 2000 new chemicals introduced annually have not yet undergone neurotoxicity testing. This review concentrated on motor development effects associated with exposure to environmental neurotoxicants to help identify critical windows of exposure and begin to assess data needs based on a subset of chemicals thoroughly reviewed by the Agency for Toxic Substances and Disease Registry (ATSDR) in Toxicological Profiles and Addenda. Multiple windows of sensitivity were identified that differed based on the maturity level of the neurological system at the time of exposure, as well as dose and exposure duration. Similar but distinct windows were found for both motor activity (GD 8–17 [rats], GD 12–14 and PND 3–10 [mice]) and motor function performance (insufficient data for rats, GD 12–17 [mice]). Identifying specific windows of sensitivity in animal studies was hampered by study designs oriented towards detection of neurotoxicity that occurred at any time throughout the developmental process. In conclusion, while this investigation identified some critical exposure windows for motor development effects, it demonstrates a need for more acute duration exposure studies based on neurodevelopmental windows, particularly during the exposure periods identified in this review.

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“…For rodents exposed to perc after birth, one study of mice showed no neurobehavioral effects immediately after exposure ceased at PD17, but the mice exhibited increased locomotion and total activity and decreased rearing at PD 60 (Fredriksson et al, 1993).…”

Section: Postnatal Outcomesmentioning

confidence: 99%

Early lifestage exposure and potential developmental susceptibility to tetrachloroethylene

Dzubow

Makris

Scott

et al. 2009

Birth Defects Research Pt B

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The limited evidence on early lifestage exposure to perc does not provide sufficient evidence of this sensitive period as being more or less important than exposure at a later lifestage, such as during adulthood. However, there are a number of adverse health effects observed uniquely in early lifestages, and increased sensitivity to visual system deficits is suggested in children. Other outcomes observed in adults may not have been adequately assessed in children to directly compare sensitivity.

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Altered behaviour in adult mice orally exposed to tri- and tetrachloroethylene as neonates

Cited by 25 publications

References 21 publications

The Potential of Selected Brominated Flame Retardants to Affect Neurological Development

The Potential of Selected Brominated Flame Retardants to Affect Neurological Development

Windows of sensitivity to toxic chemicals in the motor effects development

Early lifestage exposure and potential developmental susceptibility to tetrachloroethylene

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