Altered attention networks in benign childhood epilepsy with centrotemporal spikes (BECTS): A resting-state fMRI study

Xiao, Fenglai; Li, Lei; An, Dongmei; Lei, Du; Tang, Yingying; Yang, Tianhua; Ren, Jiechuan; Chen, Sihan; Huang, Xiaoqi; Gong, Qiyong; Zhou, Dong

doi:10.1016/j.yebeh.2015.01.016

Cited by 37 publications

(41 citation statements)

References 44 publications

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“…Although studies of connectivity and white matter integrity are lacking in these groups, fMRI may afford an additional marker of comorbid disease. In children with benign childhood epilepsy and ADHD, resting‐state fMRI demonstrates a decrease in the blood oxygen level–dependent (BOLD) signal in the dorsal attention network (DAN) compared to children with epilepsy without ADHD, thereby implicating changes in the interplay between sensory stimuli and control of spatial attention . As with the findings described in patients with epilepsy and ID, no prospective studies are yet available to delineate the timeline of these anatomic and functional changes with regard to the development of the comorbidity.…”

Section: Imaging Biomarkers Of Comorbiditiesmentioning

confidence: 99%

WONOEP appraisal: Biomarkers of epilepsy‐associated comorbidities

et al. 2016

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Neurologic and psychiatric comorbidities are common in patients with epilepsy. Diagnostic, predictive, and pharmacodynamic biomarkers of such comorbidities do not exist. They may share pathogenetic mechanisms with epileptogenesis/ictogenesis, and as such are an unmet clinical need. The objectives of the subgroup on biomarkers of comorbidities at the XIII Workshop on the Neurobiology of Epilepsy (WONOEP) were to present the state-of-the-art recent research findings in the field that highlighting potential biomarkers for comorbidities in epilepsy. We review recent progress in the field, including molecular, imaging, and genetic biomarkers of comorbidities as discussed during the WONOEP meeting on August 31-September 4, 2015, in Heybeliada Island (Istanbul, Turkey). We further highlight new directions and concepts from studies on comorbidities and potential new biomarkers for the prediction, diagnosis, and treatment of epilepsy-associated comorbidities. The activation of various molecular signaling pathways such as the "Janus Kinase/Signal Transducer and Activator of Transcription," "mammalian Target of Rapamycin," and oxidative stress have been shown to correlate with the presence and severity of subsequent cognitive abnormalities. Furthermore, dysfunction in serotonergic transmission, hyperactivity of the hypothalamic-pituitary-adrenocortical axis, the role of the inflammatory cytokines, and the contributions of genetic factors have all recently been regarded as relevant for understanding epilepsy-associated depression and cognitive deficits. Recent evidence supports the utility of imaging studies as potential biomarkers. The role of such biomarker may be far beyond the diagnosis of comorbidities, as accumulating clinical data indicate that comorbidities can predict epilepsy outcomes. Future research is required to reveal whether molecular changes in specific signaling pathways or advanced imaging techniques could be detected in the clinical settings and correlate with epilepsy-associated comorbidities. A reliable biomarker will allow a more accurate diagnosis and improved treatment of epilepsy-associated comorbidities.

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Section: Imaging Biomarkers Of Comorbiditiesmentioning

confidence: 99%

WONOEP appraisal: Biomarkers of epilepsy‐associated comorbidities

et al. 2016

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“…Both increases and decreases of connectivity within frontal regions are reported, with the variability likely being related to choice of analytical method and specific ROIs. Finally, decreased within‐network connectivity involving the dorsal attention network is also reported …”

Section: Functional Network In Cectsmentioning

confidence: 68%

“…Specifically, increased connectivity between the left and right superior frontal cortices and decreased connectivity between the DMN and language‐related cortical regions have been observed. Another study dividing children with CECTS into groups with and without attention‐deficit/hyperactivity disorder (ADHD) found increased connectivity between DMN and regions of visual association cortex in both groups compared to healthy controls …”

Section: Functional Network In Cectsmentioning

confidence: 99%

“…A positive correlation between the segregation of DMN components, that is, the extent to which the anatomic network components were able to function independently, and intelligence quotient (IQ), verbal comprehension, and perceptual reasoning has been reported . In other studies, however, tests of correlation between connectivity measures and IQ reveal no significant results even when performance in one or more domains is decreased in the children with CECTS . None of the reviewed papers included targeted assessments of social cognition.…”

Section: Functional Network In Cectsmentioning

confidence: 99%

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The epileptic network and cognition: What functional connectivity is teaching us about the childhood epilepsies

2019

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Our objective was to summarize and evaluate the rapidly expanding body of literature studying functional connectivity in childhood epilepsy. In the self‐limited childhood epilepsies, awareness of cognitive comorbidities has been steadily increasing, and recent advances in our understanding of the network effects of these disorders promise insights into the underlying neurobiology. We reviewed publications addressing functional connectivity in children with epilepsy with an emphasis on studies of children with self‐limited childhood epilepsies. The majority of studies have been published in the past 10 years and predominantly examine childhood epilepsy with centrotemporal spikes and childhood absence epilepsy. Cognitive network alterations are commonly observed across the childhood epilepsies. Some of these effects appear to be nonspecific to epilepsy syndrome or even to category of neurological disorder. Other patterns, such as changes in the connectivity of cortical language areas in childhood epilepsy with centrotemporal spikes, provide clues to the underlying cognitive deficits seen in affected children. The literature to date is dominated by general observations of connectivity patterns without a priori hypotheses. These data‐driven studies build an important foundation for hypothesis generation and are already providing useful insights into the neuropathology of the childhood epilepsies. Future work should emphasize hypothesis‐driven approaches and rigorous clinical correlations to better understand how the knowledge of network alterations can be applied to guidance and treatment for the children in our clinics.

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“…Patients with BECTS that develop attention deficit hyperactivity disorder (ADHD) show decreased functional connectivity of the DAN and ventral attention network (VAN), as well as increased connectivity of the DMN. These findings indicate that network disruption underlies language and behavioral problems in children with BECTS that presents with a less benign form of the disorder (Xiao et al 2015b).…”

Section: Focal Epilepsiesmentioning

confidence: 81%