Altered amplitude of low‐frequency fluctuations and regional homogeneity in drug‐resistant epilepsy patients with vagal nerve stimulators under different current intensity

Zhu, Jin; Xu, Cuiping; Xi, Zhang; Qiao, Li; Wang, Xueyuan; Zhang, Xiaohua; Yan, Xiaoming; Ni, Duanyu; Yu, Tao; Zhang, Guojun; Li, Yongjie

doi:10.1111/cns.13449

Cited by 17 publications

(16 citation statements)

References 37 publications

(37 reference statements)

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“…Subsequently, it should be noted that before ALFF calculation, fMRI images were spatially smoothed with full-width at half maximum (FWHM) 6 mm × 6 mm × 6 mm Gaussian kernel [ 44 ]. Before ReHo calculation, fMRI images were temporally band-pass filtered (0.01–0.08 Hz) to reduce low frequency drift and physiological high frequency respiratory and cardiac noise [ 8 , 45 ], and we didn’t perform spatial smoothness before ReHo calculation.…”

Section: Methodsmentioning

confidence: 99%

“…It should be noted that several kinds of multiple comparison correction strategies on statistical maps of ALFF and ReHo were carried out to increase test-retest reliability. The first strategy was a two-tailed GRF correlation with a single-voxel threshold of p < 0.001 and cluster-defining threshold of p < 0.05 [ 45 , 48 , 49 ]. The second method was an FDR correction ( p < 0.05) [ 50 , 51 ].…”

Section: Methodsmentioning

confidence: 99%

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Altered spontaneous neural activity in the precuneus, middle and superior frontal gyri, and hippocampus in college students with subclinical depression

Zhang

Liu

et al. 2021

BMC Psychiatry

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Background Subclinical depression (ScD) is a prevalent condition associated with relatively mild depressive states, and it poses a high risk of developing into major depressive disorder (MDD). However, the neural pathology of ScD is still largely unknown. Identifying the spontaneous neural activity involved in ScD may help clarify risk factors for MDD and explore treatment strategies for mild stages of depression. Methods A total of 34 ScD subjects and 40 age-, sex-, and education-matched healthy controls were screened from 1105 college students. The amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) of resting-state fMRI were calculated to reveal neural activity. Strict statistical strategies, including Gaussian random field (GRF), false discovery rate (FDR), and permutation test (PT) with threshold-free cluster enhancement (TFCE), were conducted. Based on the altered ALFF and ReHo, resting-state functional connectivity (RSFC) was further analyzed using a seed-based approach. Results The right precuneus and left middle frontal gyrus (MFG) both showed significantly increased ALFF and ReHo in ScD subjects. Moreover, the left hippocampus and superior frontal gyrus (SFG) showed decreased ALFF and increased ReHo, respectively. In addition, ScD subjects showed increased RSFC between MFG and hippocampus compared to healthy controls, and significant positive correlation was found between the Beck Depression Inventory-II (BDI-II) score and RSFC from MFG to hippocampus in ScD group. Conclusion Spontaneous neural activities in the right precuneus, left MFG, SFG, and hippocampus were altered in ScD subjects. Functional alterations in these dorsolateral prefrontal cortex and default mode network regions are largely related to abnormal emotional processing in ScD, and indicate strong associations with brain impairments in MDD, which provide insight into potential pathophysiology mechanisms of subclinical depression.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Altered spontaneous neural activity in the precuneus, middle and superior frontal gyri, and hippocampus in college students with subclinical depression

Zhang

Liu

et al. 2021

BMC Psychiatry

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“…If yes, it would be safer and more convenient to achieve therapeutic effects than current used invasive therapies such as deep brain stimulation and vagal nerve stimulation. 38 , 39 In summary, music adjuvant therapy could enhance the anti‐seizure efficacy of sub‐dose AEDs and provide a promising and convenient noninvasive adjuvant therapy for TLE.…”

Section: Discussionmentioning

confidence: 99%

“…However, given the desirable adjuvant therapeutic effect on kindled seizures has been observed, we can optimistically speculate that patients with drug‐resistant TLE may also benefit from music adjuvant therapy. If yes, it would be safer and more convenient to achieve therapeutic effects than current used invasive therapies such as deep brain stimulation and vagal nerve stimulation 38,39 . In summary, music adjuvant therapy could enhance the anti‐seizure efficacy of sub‐dose AEDs and provide a promising and convenient noninvasive adjuvant therapy for TLE.…”

Section: Discussionmentioning

confidence: 99%

Long‐term music adjuvant therapy enhances the efficacy of sub‐dose antiepileptic drugs in temporal lobe epilepsy

Nao

Shen

et al. 2021

CNS Neurosci Ther

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Aims Noninvasive music adjuvant therapy shows great potential in improving seizure control when combined with routine antiepileptic drugs. However, the diversity of previous music protocols has resulted in disparate outcomes. The optimized protocol and features for music adjuvant therapy are still not fully understood which limits its feasibility. Methods By applying different regimens of music therapy in various temporal lobe epilepsy models, we evaluated the effect of music in combination with sub‐dose drugs on epileptic seizures to determine the optimized protocol. Results A subgroup of kindled mice that were responsive to music adjuvant therapy was screened. In those mice, sub‐dose drugs which were noneffective on kindled seizures, alleviated seizure severity after 12 h/day Mozart K.448 for 14 days. Shorter durations of music therapy (2 and 6 h/day) were ineffective. Furthermore, only full‐length Mozart K.448, not its episodes or other music varieties, was capable of enhancing the efficacy of sub‐dose drugs. This music therapeutic effect was not due to increasing cerebral drug concentration, but instead was related with the modulation of seizure electroencephalogram (EEG) spectral powers in the hippocampus. Conclusion These results indicate that long‐term full‐length Mozart K.448 could enhance the anti‐seizure efficacy of sub‐dose drugs and may be a promising noninvasive adjuvant therapy for temporal lobe epilepsy.

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“…It is found that the stimulation of the vagus nerve can improve the mood, consciousness, and memory in some patients, and thus further improve the quality of life in epileptic patients. It has been internationally recognized as a safe and effective treatment for children and adults with local and comprehensive intractable epilepsy, and its adaptive population is continuously increasing 102,104,110,111,113,114 …”

Section: Potential Alternative Therapies For Drug‐resistant Focal Epilepsymentioning

confidence: 99%

Potential surgical therapies for drug‐resistant focal epilepsy

et al. 2021

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Drug‐resistant focal epilepsy (DRFE), defined by failure of two antiepileptic drugs, affects 30% of epileptic patients. Epilepsy surgeries are alternative options for this population. Preoperative evaluation is critical to include potential candidates, and to choose the most appropriate procedure to maximize efficacy and simultaneously minimize side effects. Traditional procedures involve open skull surgeries and epileptic focus resection. Alternatively, neuromodulation surgeries use peripheral nerve or deep brain stimulation to reduce the activities of epileptogenic focus. With the advanced improvement of laser‐induced thermal therapy (LITT) technique and its utilization in neurosurgery, magnetic resonance‐guided LITT (MRgLITT) emerges as a minimal invasive approach for drug‐resistant focal epilepsy. In the present review, we first introduce drug‐resistant focal epilepsy and summarize the indications, pros and cons of traditional surgical procedures and neuromodulation procedures. And then, focusing on MRgLITT, we thoroughly discuss its history, its technical details, its safety issues, and current evidence on its clinical applications. A case report on MRgLITT is also included to illustrate the preoperational evaluation. We believe that MRgLITT is a promising approach in selected patients with drug‐resistant focal epilepsy, although large prospective studies are required to evaluate its efficacy and side effects, as well as to implement a standardized protocol for its application.

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Altered amplitude of low‐frequency fluctuations and regional homogeneity in drug‐resistant epilepsy patients with vagal nerve stimulators under different current intensity

Cited by 17 publications

References 37 publications

Altered spontaneous neural activity in the precuneus, middle and superior frontal gyri, and hippocampus in college students with subclinical depression

Altered spontaneous neural activity in the precuneus, middle and superior frontal gyri, and hippocampus in college students with subclinical depression

Long‐term music adjuvant therapy enhances the efficacy of sub‐dose antiepileptic drugs in temporal lobe epilepsy

Potential surgical therapies for drug‐resistant focal epilepsy

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