Altered amino acid homeostasis in subjects affected by fibromyalgia

Bazzichi, Laura; Palego, Lionella; Giannaccini, Gino; Rossi, Alessandra; Feo, Francesca De; Giacomelli, Camillo; Betti, Laura; Giusti, Laura; Mascia, G.; Bombardieri, Stefano; Lucacchini, Antonio

doi:10.1016/j.clinbiochem.2009.02.025

Cited by 26 publications

(25 citation statements)

References 41 publications

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“…The finding of increased methionine sulfoxide in women with FM vs. comparators may be linked to the lower levels of l-Met, as oxidation of Met by reaction oxygen species produces methionine sulfoxide (both the R and S diastereomers). 36 Similar to the present study, Bazzichi et al 37 reported that individuals with FM (n = 34) had significantly lower plasma concentration of Met (P < 0.0001) as compared with the comparison group (n = 18), again suggesting that lower levels of Met may reflect reduced protection against oxidative stress. Other studies have linked high levels of plasma methionine sulfoxide with aging and memory impairment.…”

Section: Metabolomic Differentials In Fibromyalgiasupporting

confidence: 87%

“…reported an association between higher plasma anthranilic acid and a greater risk of dementia. Other studies have reported elevated levels of KYN or lower levels of Trp in persons with FM. Together, these studies suggest that disruption of KP metabolic homeostasis may have potential clinical consequences in persons with FM, the symptomatology of which has been reported to include cognitive impairment described as “fibrofog” and distressed mood such as depression and anxiety .…”

Section: Discussionmentioning

confidence: 86%

See 1 more Smart Citation

Metabolomic Differentials in Women With and Without Fibromyalgia

Menzies

Starkweather

Yao

et al. 2019

Clinical Translational Sci

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A nontargeted plasma metabolomic analysis was conducted to compare differentially expressed metabolites in women with and without fibromyalgia (FM) using data and samples collected from two parent studies in women with FM (n = 20) and comparative data collected from newly recruited age‐matched women (n = 20). Blood plasma samples were analyzed for metabolite content using liquid chromatography mass spectrometry. Consolidation of positive and negative ion mode metabolomics data with fold change (>2 or <0.5) and variable importance of projection scores ≥1 revealed statistically significant metabolites comparing samples from women with and without FM. Metabolite profiles in patients with FM differed from the comparison group in energy, lipid and amino acid metabolites reflecting heightened oxidative stress, inflammation, and tryptophan degradation in patients with FM. Study results may contribute to further identification of unique metabolomic profiles enhancing understanding of the pathophysiology of FM and for the development of effective therapeutic options.

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Section: Metabolomic Differentials In Fibromyalgiasupporting

confidence: 87%

Section: Discussionmentioning

confidence: 86%

Metabolomic Differentials in Women With and Without Fibromyalgia

Menzies

Starkweather

Yao

et al. 2019

Clinical Translational Sci

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“…Our research group have been studying FM since 2003, publishing numerous articles about this item [7][8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Thyroid autoimmunity may represent a predisposition for the development of fibromyalgia?

et al. 2010

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In our previous study, we observed that the presence of autoimmune thyroid disease worsens fibromyalgia (FM) symptoms. The aims of this study are to evaluate whether there is a predisposition for the development of FM in patients with Hashimoto's thyroiditis (HT) with or without subclinical hypothyroidism (SCH) and in patients with SCH alone and what is the weight of antithyroid antibody positivity and SCH on FM comorbidity. Fifty-two patients, 39 affected by HT with or without SCH and 13 by SCH, were matched with 37 patients affected by FM and 25 healthy subjects. Blood samples were collected from all study subjects for the determination of serum TSH, free triiodothyronine, free thyroxine, antithyroperoxidase antibody (TPOAb), antithyroglobulin antibody (TgAb) and non-organ-specific autoantibodies. Clinical assessment of patients and controls included the "Fibromyalgia Impact Questionnaire" (FIQ), while pain severity was evaluated using a visual analogue scale (VAS). Patients and controls were also characterized by the presence of diffuse pain, fatigue, paresthesiae, muscle spasms, non-restful sleep, tension headache and presence of mood disorders. FM comorbidity resulted in twelve HT subjects (31%) and none in SCH patient. In particular, FM comorbidity in HT patients without SCH was 33.3% and in HT patients with SCH was 28.5%. Based on our data, we speculate that maybe there is more than a hypothesis regarding the cause-effect relation between thyroid autoimmunity and the presence of FM, thus suggesting a hypothetical role of thyroid autoimmunity in FM pathogenesis.

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“…Russel and colleagues discovered an abnormality in the conversion stage of 3-hydroxy kynurenine in the CNS in FM patients 39,48. Since then, research into the attributes of tryptophan in the context of CFS/FM has continued 42,43,56,57. A couple of subsequent studies examined amino acid urinary profiles and other biochemical parameters in CFS patients and controls, without specific mention of tryptophan 58,59…”

Section: Tryptophan Status In Cfs/fmmentioning

confidence: 99%

A Brief Historic Overview of Clinical Disorders Associated with Tryptophan: The Relevance to Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM).

Blankfield¹

2012

Int J�Tryptophan�Res

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Last century there was a short burst of interest in the tryptophan related disorders of pellagra and related abnormalities that are usually presented in infancy.1,2 Nutritional physiologists recognized that a severe human dietary deficiency of either tryptophan or the B group vitamins could result in central nervous system (CNS) sequelae such as ataxia, cognitive dysfunction and dysphoria, accompanied by skin hyperpigmentation.3,4 The current paper will focus on the emerging role of tryptophan in chronic fatigue syndrome (CFS) and fibromyalgia (FM).

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Altered amino acid homeostasis in subjects affected by fibromyalgia

Cited by 26 publications

References 41 publications

Metabolomic Differentials in Women With and Without Fibromyalgia

Metabolomic Differentials in Women With and Without Fibromyalgia

Thyroid autoimmunity may represent a predisposition for the development of fibromyalgia?

A Brief Historic Overview of Clinical Disorders Associated with Tryptophan: The Relevance to Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM).

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