Altered alanine aminotransferase and γ-glutamyl transpeptidase in women with history of preeclampsia: association with waist-to-hip ratio and body mass index

Portelinha, Ana; Cerdeira, Ana Sofia; Belo, Luı́s; Tejera, Eduardo; Pinto, Fátima; Pinto, A. C. S.; Rebelo, Irene

doi:10.1097/meg.0b013e32831d81a7

Cited by 3 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A study looking at 89 women 6 years after a preeclamptic pregnancy, with an average age of 29 years, found no difference in CRP levels when compared to those with a history of normal pregnancies [35]. However, another group reported that CRP was elevated in previously preeclamptic women (n=63) and in women with previous gestational hypertension (n=105), 8 years post-delivery, with an average age of 35 years, but this lost statistical significance when corrected for BMI [36].…”

Section: Discussionmentioning

confidence: 99%

Hypertension in pregnancy is associated with elevated C-reactive protein levels later in life

Brown¹,

Turner

Bailey

et al. 2013

Journal of Hypertension

View full text Add to dashboard Cite

Objectives We assessed if hypertension in pregnancy is associated with elevated CRP levels in later life, possibly reflecting an increased risk of CVD. Background Elevated C-reactive protein (CRP) levels have been associated with hypertension in pregnancy and with cardiovascular disease (CVD). Methods We studied 2463 women from the Genetic Epidemiology Network of Arteriopathy (GENOA) study. Subjects were categorized as nulliparous women (n=219), women with a history of normotensive pregnancies (n=1839), or women with a history of a hypertensive pregnancy (n=405). Using multiple linear regression models we compared mean CRP levels among the groups after adjusting for age, race, education, smoking, hypertension, personal history of CHD or stroke, diabetes, dyslipidemia, statins, hormone replacement therapy, and family history of CHD or stroke. As CRP levels may be influenced by body mass index (BMI), the model was fit both with and without adjusting for BMI. Results There was no significant difference in CRP levels between nulliparous women and those with a history of normotensive pregnancies, either with (p=0.82) or without (p=0.46) adjusting for BMI. In contrast, women with hypertensive pregnancies, compared to those with normotensive pregnancies, had higher CRP levels, both with (p=0.009) and without (p<0.001) adjusting for BMI. Conclusions A history of hypertension in pregnancy is associated with elevated CRP levels later in life, independent of traditional CVD risk factors and BMI. An elevated CRP may reflect an inflammatory state in women with a history of hypertensive pregnancy disorders who are at increased risk for CVD.

show abstract

Section: Discussionmentioning

confidence: 99%

Hypertension in pregnancy is associated with elevated C-reactive protein levels later in life

Brown¹,

Turner

Bailey

et al. 2013

Journal of Hypertension

View full text Add to dashboard Cite

show abstract

“…Plasma creatinine (Cr), uric acid (UA), and estimated glomerular filtration rate (eGFR) are widely used as indicators for renal dysfunction (9,10). Previous case-control studies have found that serum GGT, ALP, LDH, and UA levels are increased in women diagnosed with HDP (11)(12)(13)(14)(15)(16)(17). Recently, several studies have reported that lower AST/ALT was associated with insulin resistance, metabolic syndrome and cardiovascular disease (18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Increased Uric Acid, Gamma-Glutamyl Transpeptidase and Alkaline Phosphatase in Early-Pregnancy Associated With the Development of Gestational Hypertension and Preeclampsia

Chen

Ou²,

Lin³

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Background: Previous studies have reported that biomarkers of liver injury and renal dysfunction were associated with hypertensive disorders of pregnancy (HDP). However, the associations of these biomarkers in early pregnancy with the risk of HDP and longitudinal blood pressure pattern during pregnancy were rarely investigated in prospective cohort studies.Methods: A total of 1,041 pregnant women were enrolled in this prospective cohort study. BP was assessed in four stages throughout pregnancy. The following biomarkers were measured at early pregnancy before 18 weeks gestation: lactate dehydrogenase (LDH), aspartate aminotransferase to alanine aminotransferase ratio (AST/ALT), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), uric acid (UA), and estimated glomerular filtration rate (eGFR). Linear mixed-effects and logistic regression models were used to examine the associations of these biomarkers with longitudinal BP pattern during pregnancy and HDP incidence, respectively.Results: In unadjusted models, higher serum UA, GGT, ALP, and LDH levels, as well as lower eGFR and AST/ALT, were associated with higher BP levels during pregnancy and an increased risk of HDP. After adjustment for maternal age, pre-pregnancy BMI and other potential confounders, UA, GGT, ALP, and LDH remained positively associated with both BP and HDP. However, eGFR and AST/ALT were not associated with HDP after adjusting for potential confounders. When including all 6 biomarkers simultaneously in multivariable analyses, increased UA, GGT, and ALP significantly associated with gestational hypertension and preeclampsia.Conclusion: This study suggests that increased UA, GGT, and ALP in early-pregnancy are independent risk factors of gestational hypertension and preeclampsia.

show abstract

Preeclampsia and future maternal health

Carty

Delles

Dominiczak

2010

Journal of Hypertension

137

View full text Add to dashboard Cite

Preeclampsia is a multisystem disorder that complicates 3-8% of pregnancies in the Western world, and is a major source of morbidity and mortality worldwide. Although it is a disease unique to pregnancy, evidence has mounted in recent years that preeclampsia has important implications for future maternal health, in particular cardiovascular health. In this review we examine epidemiological evidence for this relationship, and examine potential mechanisms such as insulin resistance, genetic factors and endothelial dysfunction that may explain the relationship. In addition we explore potential future avenues of research into the field, such as genomics, proteomics and metabolomics.

show abstract

Altered alanine aminotransferase and γ-glutamyl transpeptidase in women with history of preeclampsia: association with waist-to-hip ratio and body mass index

Abstract: It is possible that the increase in ALT and gammaGT levels is due to being overweight or through accumulation of visceral fat. Unaltered values of CRP suggest that the higher ALT and gammaGT values found in women with history of PE are not associated with inflammation.

Cited by 3 publications

References 21 publications

Hypertension in pregnancy is associated with elevated C-reactive protein levels later in life

Hypertension in pregnancy is associated with elevated C-reactive protein levels later in life

Increased Uric Acid, Gamma-Glutamyl Transpeptidase and Alkaline Phosphatase in Early-Pregnancy Associated With the Development of Gestational Hypertension and Preeclampsia

Preeclampsia and future maternal health

Contact Info

Product

Resources

About