Altered adipocytokine profile predicts early stage of left ventricular remodeling in hypertensive patients with type 2 diabetes mellitus

Біловол, Олександр Миколайович; Knyazkova, І. І.; Al-Travneh, Olena V.; Bogun, Maryna; Berezin, Alexander E.

doi:10.1016/j.dsx.2020.01.011

Cited by 9 publications

(12 citation statements)

References 49 publications

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“…Recent studies showed the negative effects of acute hyperglycemia on systolic LV global longitudinal strain and multilayer longitudinal and circumferential strain in asymptomatic T2DM and unfavorable subclinical reductions in global and average circumferential strain in obese adolescents with dysglycemia, which may indicate the importance of intensive blood glucose control [24,25]. Moreover, epicardial adipose tissue may be associated with LV structural and functional abnormalities and exercise intolerance in T2DM patients with asymptomatic heart failure [26], and serum levels of omentin-1 and Zinc-α2-glycoprotein have been recently defined as the most important predictors for LV hypertrophy and LV diastolic dysfunction in T2DM patients [27]. Our study demonstrated that T2DM aggravated LV systolic dysfunction as represented by more severe impairment of GLPS and GRPS and the occurrence of impaired GCPS in the HTN (T2DM+) group, even though similar LVEF and LV geometries were observed between the hypertensive subgroups.…”

Section: Table 4 Multivariable Association Of Diabetes With First-pasmentioning

confidence: 99%

The additive effects of type 2 diabetes mellitus on left ventricular deformation and myocardial perfusion in essential hypertension: a 3.0 T cardiac magnetic resonance study

Jiang

Guo

et al. 2020

Cardiovasc Diabetol

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Background Type 2 diabetes mellitus (T2DM) increases the risks of heart failure and mortality in patients with hypertension, however the underlying mechanism is unclear. This study aims to investigate the impact of coexisting T2DM on left ventricular (LV) deformation and myocardial perfusion in hypertensive individuals. Materials and methods Seventy hypertensive patients without T2DM [HTN(T2DM−)], forty patients with T2DM [HTN(T2DM+)] and 37 age- and sex-matched controls underwent cardiac magnetic resonance examination. Left ventricular (LV) myocardial strains, including global radial (GRPS), circumferential (GCPS) and longitudinal peak strain (GLPS), and resting myocardial perfusion indices, including upslope, time to maximum signal intensity (TTM), and max signal intensity (MaxSI), were measured and compared among groups by analysis of covariance after adjusting for age, sex, body mass index (BMI) and heart rate followed by Bonferroni’s post hoc test. Backwards stepwise multivariable linear regression analyses were performed to determine the effects of T2DM on LV strains and myocardial perfusion indices in patients with hypertension. Results Both GRPS and GLPS deteriorated significantly from controls, through HTN(T2DM−), to HTN(T2DM+) group; GCPS in HTN(T2DM+) group was lower than those in both HTN(T2DM−) and control groups. Compared with controls, HTN(T2DM−) group showed higher myocardial perfusion, and HTN(T2DM+) group exhibited lower perfusion than HTN(T2DM−) group and controls. Multiple regression analyses considering covariates of systolic blood pressure, age, sex, BMI, heart rate, smoking, indexed LV mass and eGFR demonstrated that T2DM was independently associated with LV strains (GRPS: p = 0.002, model R2= 0.383; GCPS: p < 0.001, model R2= 0.472; and GLPS: p = 0.002, model R2= 0.424, respectively) and perfusion indices (upslope: p < 0.001, model R2= 0.293; TTM: p < 0.001, model R2= 0.299; and MaxSI: p < 0.001, model R2= 0.268, respectively) in hypertension. When both T2DM and perfusion indices were included in the regression analyses, both T2DM and TTM were independently associated with GRPS (p = 0.044 and 0.017, model R2= 0.390) and GCPS (p = 0.002 and 0.001, model R2= 0.424), and T2DM but not perfusion indices was independently associated with GLPS (p = 0.002, model R2= 0.424). Conclusion In patients with hypertension, T2DM had an additive deleterious effect on subclinical LV systolic dysfunction and myocardial perfusion, and impaired myocardial perfusion by coexisting T2DM was associated with deteriorated LV systolic dysfunction.

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Section: Table 4 Multivariable Association Of Diabetes With First-pasmentioning

confidence: 99%

The additive effects of type 2 diabetes mellitus on left ventricular deformation and myocardial perfusion in essential hypertension: a 3.0 T cardiac magnetic resonance study

Jiang

Guo

et al. 2020

Cardiovasc Diabetol

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“…Although there is a wide range of evidence regarding the positive impact of various antidiabetic drugs on the adipocytokine profile, there are not strong findings confirming CV risk modification in connection with up-regulation of irisin expression in target tissues (including VAT, liver, and myocardium) and peripheral blood among T2DM patients [39,40]. Interestingly, serum levels of irisin in the non-diabetic population were inversely associated with conventional CV risk factors and biomarkers of metabolic phenotype, while T2DM patients did not show these associations [41].…”

Section: Irisin and CV Risk In T2dm And Non-t2dm Populationsmentioning

confidence: 99%

The Hormone-like Myokines Irisin as Novel Biomarker for Cardiovascular Risk Stratification”,

Berezin¹,

Myrnyi²,

Myrnyi³

et al. 2021

Pharmacophore

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As a skeletal muscle cell-derived protein, Irisin regulates glucose and lipid metabolism, mitochondrial function, myogenesis, switching white adipocytes to brown fat-like cells, and thermogenesis and energy expenditure. The descriptive review aim is to summarize the knowledge regarding irisin as novel molecular mediators of energy metabolism of remote tissue with promising diagnostic and predictive values for CV risk in connection with a presence of metabolic conditions. The following database were used for searching of life science and biomedical information MEDLINE, the Web of Science, Medline (PubMed), the Cochrane Central, and EMBASE English publications to satisfy the keywords of this investigation. Lowered concentrations of irisin were found in the patients with known CV disease including heart failure, Type 2 Diabetes Mellitus (T2DM), but the levels of circulating irisin were increased in obesity and pre-diabetes patients compared to healthy volunteers. In the general population, low levels of irisin have closely predicted T2DM, atherosclerosis, and coronary artery disease. Circulating levels of irisin in patients that have incident Heart Failure (HF) with reduced ejection fraction were related to the severity of the disease and can be a marker of cardiac cachexia. In contrast, in acute HF patients increased the levels of irisin in peripheral blood positively related to a one-year CV mortality rate. Large clinical studies are needed to determ the predictive role of irisin in the natural evolution of CV disease including HF, myocardial infarction, and cardiac cachexia.

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“…There is an opinion that decreased level of omentin in circulation in the presence of excessive fat mass is a risk factor for obesity-associated AH. According to the some data, serum omentin level is the most important marker of LV hypertrophy and LV diastolic dysfunction in T2DM patients [50].…”

Section: A Number Of Studies Established a Correlation Between Omentin Level And The Risk Of Ah Developmentmentioning

confidence: 99%

The Role of Adipokines in Cardiovascular Pathology

Подзолков

Pokrovskaya

Bazhanova

et al. 2021

Open Access Maced J Med Sci

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The recent decades saw a steady growth of obesity incidence worldwide. Obesity is an independent risk factor for cardiovascular diseases (CVDs) and type 2 diabetes mellitus and is also associated with a shorter life expectancy. Not only hemodynamic but also hormone metabolic processes, arising from excessive accumulation of adipose tissue in human body, underlie the development of CVDs. Adipose tissue has now been proved to be a hormone-active substrate. Studies of the influence of adipokines will bring us closer to understanding cardiovascular pathogenesis and help personalize prophylactic strategies.

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Altered adipocytokine profile predicts early stage of left ventricular remodeling in hypertensive patients with type 2 diabetes mellitus

Cited by 9 publications

References 49 publications

The additive effects of type 2 diabetes mellitus on left ventricular deformation and myocardial perfusion in essential hypertension: a 3.0 T cardiac magnetic resonance study

The additive effects of type 2 diabetes mellitus on left ventricular deformation and myocardial perfusion in essential hypertension: a 3.0 T cardiac magnetic resonance study

The Hormone-like Myokines Irisin as Novel Biomarker for Cardiovascular Risk Stratification”,

The Role of Adipokines in Cardiovascular Pathology

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