Altered activation of the dorsal anterior cingulate cortex during oddball performance in individuals at risk for Alzheimer's disease

Chavarría-Elizondo, Pamela; del Río-Torné, Carla; Maturana-Quijada, Pablo; Martínez-Zalacaín, Ignacio; Juaneda, Asier; del Cerro, Inés; Guinea-Izquierdo, Andrés; Gascón-Bayarri, Jordi; Reñé-Ramírez, Ramón; Urretavizcaya, Mikel; Ferrer, Isidre; Menchón, José M.; Soria, Virginia; Soriano-Mas, Carles

doi:10.1016/j.sjpmh.2024.07.001

Spanish Journal of Psychiatry and Mental Health

2024

DOI: 10.1016/j.sjpmh.2024.07.001

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Altered activation of the dorsal anterior cingulate cortex during oddball performance in individuals at risk for Alzheimer's disease

Pamela Chavarría-Elizondo,

Carla del Río-Torné,

Pablo Maturana-Quijada

et al.

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Real-Time fMRI Neurofeedback Training of Selective Attention in Older Adults

Lin,

Rana,

Liu

et al. 2024

Brain Sciences

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Background: Selective attention declines with age, due to age-related functional changes in dorsal anterior cingulate cortex (dACC). Real-time functional magnetic resonance imaging (rtfMRI) neurofeedback has been used in young adults to train volitional control of brain activity, including in dACC. Methods: For the first time, this study used rtfMRI neurofeedback to train 19 young and 27 older adults in volitional up- or down-regulation of bilateral dACC during a selective attention task. Results: Older participants in the up-regulation condition (experimental group) showed greater reward points and dACC BOLD signal across training sessions, reflective of neurofeedback training success; and faster reaction time and better response accuracy, suggesting behavioral benefits on selective attention. These effects were not observed for older participants in the down-regulation condition (inverse condition control group), supporting specificity of volitional dACC up-regulation training in older adults. These effects were, unexpectedly, also not observed for young participants in the up-regulation condition (age control group), perhaps due to a lack of motivation to continue the training. Conclusions: These findings provide promising first evidence of functional plasticity in dACC in late life via rtfMRI neurofeedback up-regulation training, enhancing selective attention, and demonstrate proof of concept of rtfMRI neurofeedback training in cognitive aging.

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Real-Time fMRI Neurofeedback Training of Selective Attention in Older Adults

Lin,

Rana,

Liu

et al. 2024

Brain Sciences

View full text Add to dashboard Cite

show abstract

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Altered activation of the dorsal anterior cingulate cortex during oddball performance in individuals at risk for Alzheimer's disease

Cited by 1 publication

References 38 publications

Real-Time fMRI Neurofeedback Training of Selective Attention in Older Adults

Real-Time fMRI Neurofeedback Training of Selective Attention in Older Adults

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