2019
DOI: 10.1016/j.transci.2019.05.001
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Altered activation of integrin ɑIIbβ3 on platelets irradiated with ultraviolet C from pathogen-reducing xenon flash

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Cited by 2 publications
(2 citation statements)
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“…Swirling was maintained in both the XeF‐FP–treated and nontreated PCs until the end of the storage, suggesting that a discoid shape was maintained in both products . Furthermore, we previously showed that PAC‐1–positive PLTs induced by the UVC irradiation from Xe flash did not bind to fibrinogen under resting condition in suspension . The changes in the above parameters in XeF‐FP–treated PCs were statistically significant as compared with those in the nontreated ones, but the clinical significance of these changes is unclear at present.…”
Section: Discussionmentioning
confidence: 89%
“…Swirling was maintained in both the XeF‐FP–treated and nontreated PCs until the end of the storage, suggesting that a discoid shape was maintained in both products . Furthermore, we previously showed that PAC‐1–positive PLTs induced by the UVC irradiation from Xe flash did not bind to fibrinogen under resting condition in suspension . The changes in the above parameters in XeF‐FP–treated PCs were statistically significant as compared with those in the nontreated ones, but the clinical significance of these changes is unclear at present.…”
Section: Discussionmentioning
confidence: 89%
“…Our study showed no difference in the adhesion of PLTs to fibrinogen between flash UVC‐irradiated and nonirradiated groups. We previously reported that fibrinogen in soluble form bound to flash UVC‐irradiated PLTs upon ADP stimulation, although it did not bind to irradiated PLTs without ADP stimulation under liquid‐phase conditions 20 . These results suggest that flash UVC irradiation did not affect αIIbβ3‐fibrinogen interaction and subsequent signals in our limited observations.…”
Section: Discussionmentioning
confidence: 40%