Alterations of white matter integrity related to motor activity in schizophrenia

Walther, Sebastian; Federspiel, Andrea; Horn, Helge; Razavi, Nadja; Wiest, Roland; Dierks, Thomas; Strik, Werner; Müller, Thomas

doi:10.1016/j.nbd.2011.01.017

Cited by 90 publications

(63 citation statements)

References 90 publications

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“…The amount of motor activity a person engages himself/herself in is the end-point of many possible processes. Our hypothesis of the predictive value of qualitative motor disturbances was, on the one hand, based on the assumption that if successful movement execution is hampered in some way, this would lead to a diminishing in motor activity and, on the other hand, on neuroimaging studies reporting associations between motor AL and alterations in the brain motor pathways [5,6,7,8]. However, the results of this study suggest that other processes than qualitative motor performance are responsible for the diminished motor activity seen in patients with schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

“…Neurobiological research using actigraphy suggests that the reduced AL found in patients with schizophrenia are linked to basal ganglia dysfunction, which may be compensated by increased involvement of cortical motor areas (i.e. the supplementary motor area and the cingulate cortex) in the control of their voluntary motor behaviour [5,6,7,8]. …”

Section: Introductionmentioning

confidence: 99%

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Quantitative Psychomotor Dysfunction in Schizophrenia: A Loss of Drive, Impaired Movement Execution or Both?

et al. 2013

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Aims: The aim of the present study was to investigate the predictive value of qualitative psychomotor performance levels and subaspects of the negative syndrome for quantitative motor activity levels in patients with schizophrenia. Methods: Twenty-seven stabilized patients with schizophrenia and 22 age- and sex-matched healthy controls were included in the study. An extensive battery of psychomotor performance tests (Finger Tapping Test, Purdue Pegboard Test, Line Copying Test, Neurological Evaluation Scale, Salpêtrière Retardation Rating Scale), clinical rating scales (Positive and Negative Syndrome Scale) and 24-hour actigraphy were administered to all participants. Results: Correlational analyses showed that motor activity levels were associated with avolition as well as clinically assessed psychomotor slowing. However, in a regression model, only avolition was found to be a significant predictor for motor activity levels in patients with schizophrenia; none of the psychomotor performance tests nor the severity of emotional expressivity deficits contributed to the model. Conclusion: Qualitative and quantitative psychomotor deficits seem to be independent phenomena in stabilized patients with schizophrenia. The diminishing in motor activity in patients with schizophrenia is related to a loss of drive and not to problems in the quality of movement execution.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantitative Psychomotor Dysfunction in Schizophrenia: A Loss of Drive, Impaired Movement Execution or Both?

et al. 2013

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“…The t-IAF-BOLD correlates overlapped significantly with three FCNs: the DMN and the LWMN and RWMNs. The DMN is known to be related to attention, (error)-monitoring, and self-reference (Begre et al, 2008;Walther et al, 2011), while LWMN and RWMNs relate to working memory (Damoiseaux et al, 2006). This is interesting because there is also a functional overlap: alpha-band EEG activity has often been related to attention and working memory functions.…”

Section: Discussionmentioning

confidence: 99%

Linking Brain Connectivity Across Different Time Scales with Electroencephalogram, Functional Magnetic Resonance Imaging, and Diffusion Tensor Imaging

et al. 2012

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Structural and functional connectivity are intrinsic properties of the human brain and represent the amount of cognitive capacities of individual subjects. These connections are modulated due to development, learning, and disease. Momentary adaptations in functional connectivity alter the structural connections, which in turn affect the functional connectivity. Thus, structural and functional connectivity interact on a broad timescale. In this study, we aimed to explore distinct measures of connectivity assessed by functional magnetic resonance imaging and diffusion tensor imaging and their association to the dominant electroencephalogram oscillatory property at rest: the individual alpha frequency (IAF). We found that in 21 healthy young subjects, small intraindividual temporal IAF fluctuations were correlated to increased blood oxygenation level-dependent signal in brain areas associated to working memory functions and to the modulation of attention. These areas colocalized with functionally connected networks supporting the respective functions. Furthermore, subjects with higher IAF show increased fractional anisotropy values in fascicles connecting the above-mentioned areas and networks. Hence, due to a multimodal approach a consistent functionally and structurally connected network related to IAF was observed.

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“…15,16 However, the associations between positive symptoms and motor activity remain inconsistent. [14][15][16]18 Besides the analysis of average motor activity, one could also investigate the movement patterns over time, which may provide additional insight into the structure of behavior. Investigations of large-scale rhythms such as circadian rhythm disturbances, however, found no associations with psychopathology in schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Less Structured Movement Patterns Predict Severity of Positive Syndrome, Excitement, and Disorganization

Walther

Ramseyer

Horn

et al. 2013

Schizophrenia Bulletin

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Disorganized behavior is a key symptom of schizophrenia. The objective assessment of disorganized behavior is particularly challenging. Actigraphy has enabled the objective assessment of motor behavior in various settings. Reduced motor activity was associated with negative syndrome scores, but simple motor activity analyses were not informative on other symptom dimensions. The analysis of movement patterns, however, could be more informative for assessing schizophrenia symptom dimensions. Here, we use time series analyses on actigraphic data of 100 schizophrenia spectrum disorder patients. Actigraphy recording intervals were set at 2 s. Data from 2 defined 60-min periods were analyzed, and partial autocorrelations of the actigraphy time series indicated predictability of movements in each individual. Increased positive syndrome scores were associated with reduced predictability of movements but not with the overall amount of movement. Negative syndrome scores were associated with low activity levels but unrelated with predictability of movement. The factors disorganization and excitement were related to movement predictability but emotional distress was not. Thus, the predictability of objectively assessed motor behavior may be a marker of positive symptoms and disorganized behavior. This behavior could become relevant for translational research.

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Alterations of white matter integrity related to motor activity in schizophrenia

Cited by 90 publications

References 90 publications

Quantitative Psychomotor Dysfunction in Schizophrenia: A Loss of Drive, Impaired Movement Execution or Both?

Quantitative Psychomotor Dysfunction in Schizophrenia: A Loss of Drive, Impaired Movement Execution or Both?

Linking Brain Connectivity Across Different Time Scales with Electroencephalogram, Functional Magnetic Resonance Imaging, and Diffusion Tensor Imaging

Less Structured Movement Patterns Predict Severity of Positive Syndrome, Excitement, and Disorganization

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