Alterations of tryptophan metabolism induced by sleep deprivation

Kühn, Eduard; Rysánek, K; Brodan, V.

doi:10.1007/bf02138639

Cited by 14 publications

(9 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alterations of serum kynurenine pathway metabolites have been found in other neuropsychiatric disorders [ 16 ], have been linked to chronic stress [ 32 ] and sleep deprivation [ 33 ]. Although we did not recruit patients affected by psychiatric comorbidities, we cannot exclude that the chronic stress associated to the active CH condition, often associated with sleep disturbances, might have affected tryptophan metabolism.…”

Section: Discussionmentioning

confidence: 99%

Altered serum levels of kynurenine metabolites in patients affected by cluster headache

et al. 2016

View full text Add to dashboard Cite

BackgroundThe reported efficacy of memantine in the treatment of patients with cluster headache (CH) suggests that NMDA receptors are involved in mechanisms of nociceptive sensitization within the trigeminal system associated with CH. NMDA receptors are activated or inhibited by neuroactive compounds generated by tryptophan metabolism through the kynurenine pathway. In the accompanying manuscript, we have found that serum levels of all kynurenine metabolites are altered in patients with chronic migraine. Here, we have extended the study to patients affected by episodic or chronic CH as compared to healthy controls.MethodWe assessed serum levels of kynurenine (KYN), kynurenic Acid (KYNA), anthranilic acid (ANA), 3-hydroxy-anthranilic acid (3-HANA), 3-hydroxykynurenine (3-HK), xanthurenic acid (XA), quinolinic acid (QUINA), tryptophan (Trp) and 5-hydroxyindolacetic acid (5-HIAA) by means of a liquid chromatography/tandem mass spectrometry (LC/MS-MS) method in 21 patients affected by CH (15 with episodic and 6 with chronic CH), and 35 age-matched healthy subjects. Patients with psychiatric co-morbidities, systemic inflammatory, endocrine or neurological disorders, and mental retardation were excluded.ResultsLC/MS-MS analysis of kynurenine metabolites showed significant reductions in the levels of KYN (-36 %), KYNA (-34 %), 3-HK (-51 %), 3-HANA (-54 %), XA (-25 %), 5-HIAA (-39 %) and QUINA (-43 %) in the serum of the overall population of patients affected by CH, as compared to healthy controls. Serum levels of Trp and ANA were instead significantly increased in CH patients (+18 % and +54 %, respectively). There was no difference in levels of any metabolite between patients affected by episodic and chronic CH, with the exception of KYN levels, which were higher in patients with chronic CH.ConclusionThe reduced levels of KYNA (an NMDA receptor antagonist) support the hypothesis that NMDA receptors are overactive in CH. A similar reduction in KYNA levels was shown in the accompanying manuscript in patients affected by chronic migraine. The reduced levels of XA, a putative analgesic compound, may contribute to explain the severity of pain attacks in CH. These data, associated with the data reported in the accompanying manuscript, supports a role for the kynurenine pathway in the pathophysiology of chronic headache disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Altered serum levels of kynurenine metabolites in patients affected by cluster headache

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Although the relationship is not necessarily linear, there is evidence that in humans, sleep restriction increases levels of IL-6, TNF-α, CRP and IL-1β (Motivala, 2011, van Leeuwen et al, 2009, Vgontzas et al, 1999, Vgontzas et al, 2004. Five days of sleep deprivation in healthy adults also modified a number of kynurenine pathway metabolites in healthy adults, including 5-hydroxyindoleacetic acid (5-HIAA), xanthurenic acid and anthranilic acid (Kuhn et al, 1968).…”

Section: Sleep and Its Effect On Inflammationmentioning

confidence: 99%

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Lopresti

Hood

Drummond

2013

Journal of Affective Disorders

505

412

View full text Add to dashboard Cite

Research on major depression has confirmed that it is caused by an array of biopsychosocial and lifestyle factors. Diet, exercise and sleep are three such influences that play a significant mediating role in the development, progression and treatment of this condition. This review summarises animal and human-based studies on the relationship between these three lifestyle factors and major depressive disorder, and their influence on dysregulated pathways associated with depression, namely neurotransmitter processes, immuno-inflammatory pathways, hypothalamic-pituitary-adrenal (HPA) axis disturbances, oxidative stress and antioxidant defence systems, neuroprogression, and mitochondrial disturbances. Increased attention in future clinical studies on the influence of diet, sleep and exercise on major depressive disorder and investigations of their effect on physiological processes will help to expand our understanding and treatment of major depressive disorder. Mental health interventions, taking into account the bidirectional relationship between these lifestyle factors and major depression are also likely to enhance the efficacy of interventions associated with this disorder.

show abstract

“…Decreases in CORT concentrations reduce blood glucose (GLU) concentrations, which would ultimately affect GLU metabolism. Kuhn et al 11 noted increases in CORT and decreases in plasma GLU but also noted increases in free fatty acids. Because of previous inconsistent research findings, it is important to reevaluate the impact SDEP has on hormonal and endocrine function.…”

Section: Introductionmentioning

confidence: 96%

“…Thyrotropic function and the activity of the HPA axis may also be reduced by SDEP. 11 This finding is especially important with respect to cold exposure because the hypothalamus is the center of thermoregulation. Palmblad et al 12 demonstrated an increase in thyroid hormone concentrations, which were believed to be due to an increase in thyroid stimulating hormone (TSH).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Cold Exposure on the Hormonal and Metabolic Responses to Sleep Deprivation

Caine-Bish¹,

Potkanowicz

Otterstetter

et al. 2005

Wilderness & Environmental Medicine

View full text Add to dashboard Cite

Alterations of tryptophan metabolism induced by sleep deprivation

Cited by 14 publications

References 4 publications

Altered serum levels of kynurenine metabolites in patients affected by cluster headache

Altered serum levels of kynurenine metabolites in patients affected by cluster headache

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

The Effect of Cold Exposure on the Hormonal and Metabolic Responses to Sleep Deprivation

Contact Info

Product

Resources

About