Alterations of the subcommissural organ in the hydrocephalic human fetal brain

Castañeyra-Perdomo, Agustín; Meyer, Gundela; Carmona-Calero, Emilia M.; Bañuelos-Pineda, Jacinto; Méndez‐Medina, Rafael; Ormazábal-Ramos, C.; Ferres-Torres, R

doi:10.1016/0165-3806(94)90138-4

Cited by 31 publications

(12 citation statements)

References 6 publications

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“…In addition to H-Tx rats, there are many reports of SCO abnormalities in congenital hydrocephalus in different species including humans (Castaaeeyra-Perdomo et al 1994), mutant mice (Takeuchi et al 1987;PØrez-Fígares et al 1998;Bruni et al 1988), transgenic mice (Louvi and Wassef 2000;Sakakibara et al 2002;Tullio et al 2001) and mutant rats (D'Amato et al 1986;Takeuchi et al 1988;Yamada et al 1992). It is possible that an insufficiency of SCO sialoglycoproteins contributes to the hydrocephalus because sialic acid residues are important for the maintenance of the ependymal surfaces.…”

Section: The Subcommissural Organ and Hydrocephalusmentioning

confidence: 93%

Reduced subcommissural organ glycoprotein immunoreactivity precedes aqueduct closure and ventricular dilatation in H-Tx rat hydrocephalus

Somera

Jones

2004

Cell and Tissue Research

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The H-Tx rat has fetal-onset hydrocephalus associated with closure of the cerebral aqueduct and a reduction in the secretory cells of the subcommissural organ (SCO), a circumventricular organ situated in the dorsal wall of the cerebral aqueduct. The objective of this study was to determine the role of the SCO in hydrocephalus pathogenesis. Serial brain sections through aqueduct regions containing the SCO from H-Tx rats, together with non-hydrocephalic Fischer F344 rats, were studied at E16, before hydrocephalus onset, at E17, the beginning of onset, and at P0 when the hydrocephalus was overt. Tissues were immunostained by AFRU, an antibody against the SCO glycoprotein, and for the intermediate filament nestin. The area of SCO cells with AFRU immunostaining and the severity of lateral ventricle dilatation were quantified by image analysis. At E16 all fetuses had distinct SCO ependymal cells, open aqueducts and normal lateral ventricles. The H-Tx fetuses fell into two groups with large areas and small areas of AFRU immunoreactivity, all with a full complement of SCO cells. By E17, fetuses with small areas of immunoreactivity had reduced numbers of tall SCO secretory cells, and most had aqueducts closed posteriorly and dilated ventricles. Three additional fetuses with small areas of immunoreactivity had narrow but patent aqueducts and normal ventricles, and another had an open aqueduct and dilated ventricles. At P0, pups previously identified as hydrocephalic had small areas of AFRU immunoreactivity, an aqueduct that was closed anteriorly but open posteriorly, ventricular dilatation, and an absence of SCO secretory cells. The aqueduct even when closed was lined by typical ependymal cells throughout. Decreased nestin immunostaining accompanied the SCO changes. It is concluded that reduced SCO glycoprotein immunoreactivity precedes both aqueduct closure and expansion of the lateral ventricles in the H-Tx rat.

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Section: The Subcommissural Organ and Hydrocephalusmentioning

confidence: 93%

Reduced subcommissural organ glycoprotein immunoreactivity precedes aqueduct closure and ventricular dilatation in H-Tx rat hydrocephalus

Somera

Jones

2004

Cell and Tissue Research

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“…7A,C,D). Furthermore, severe morphological alterations of the SCO of hydrocephalic human fetuses have been reported (Castañ eyra-Perdomo et al, 1994).…”

Section: Congenital Hydrocephalus: a Consequence Of A Dysfunction Of mentioning

confidence: 99%

Subcommissural organ, cerebrospinal fluid circulation, and hydrocephalus

Pérez-Fígares

Jiménez

Rodríguez

2001

Microsc. Res. Tech.

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“…However, it remains obscure whether the alterations in the subcommissural organ in human fetuses are primary or epiphenomenal, 132 which may also occur in the case of rats deficient in folic acid or B12 vitamin 133 . It is difficult to claim the basis of the relationship between an altered subcommissural organ and the occlusion of the cerebral aqueduct and hydrocephalus.…”

Section: Role Of Ependyma In Ventricle Csf Production and Circulationmentioning

confidence: 99%

Structure and function of the ependymal barrier and diseases associated with ependyma disruption

et al. 2014

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The neuroepithelium is a germinal epithelium containing progenitor cells that produce almost all of the central nervous system cells, including the ependyma. The neuroepithelium and ependyma constitute barriers containing polarized cells covering the embryonic or mature brain ventricles, respectively; therefore, they separate the cerebrospinal fluid that fills cavities from the developing or mature brain parenchyma. As barriers, the neuroepithelium and ependyma play key roles in the central nervous system development processes and physiology. These roles depend on mechanisms related to cell polarity, sensory primary cilia, motile cilia, tight junctions, adherens junctions and gap junctions, machinery for endocytosis and molecule secretion, and water channels. Here, the role of both barriers related to the development of diseases, such as neural tube defects, ciliary dyskinesia, and hydrocephalus, is reviewed.

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Alterations of the subcommissural organ in the hydrocephalic human fetal brain

Cited by 31 publications

References 6 publications

Reduced subcommissural organ glycoprotein immunoreactivity precedes aqueduct closure and ventricular dilatation in H-Tx rat hydrocephalus

Reduced subcommissural organ glycoprotein immunoreactivity precedes aqueduct closure and ventricular dilatation in H-Tx rat hydrocephalus

Subcommissural organ, cerebrospinal fluid circulation, and hydrocephalus

Structure and function of the ependymal barrier and diseases associated with ependyma disruption

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