Alterations of the nucleus ruber in 3-acetylpyridine intoxication

Szalay, Jeanne; Böti, Z; Temesvári, Péter; Bara, D

doi:10.1016/s0014-4908(79)80041-1

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…It is incorporated into pyridine nuleotides and, owing to the lack of specificity of the NAD(P) nucleosidase [NAD(P) glycohydrolase], 3-AP-containing abnormal NAD(P) analogues are formed which interferes with intracellular electron transport (Szalay et aL, 1979). The impairment of the intracellular electron transport may lead to the disturbance of ATP synthesis resulting in catecholamine depletions due to the intracellular impairment of granule resynthesis.…”

Section: Discussionmentioning

confidence: 99%

“…In this case, the doses introduced into the mouse were relatively low (200 mg/kg). However, 3-AP given in one single dose near the LDs0 causes cellular necrosis in brain regions such as the red nucleus (Szalay et al, 1979), inferior olivary complex, stratum pyramidale hippocampi, and nucleus supraopticus of the rat and mouse, as well as the spinal and sympathetic ganglia and adrenal medulla (Hicks, 1955).…”

Section: Introductionmentioning

confidence: 99%

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Effects of 3-acetylpyridine on the adrenal medulla of the mouse

Shimada

Ozaki

1984

J. Neural Transmission

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In the present work, the effects of 3-acetylpyridine (3-AP) on the adrenal medulla were investigated for biochemical and morphological changes. Adrenaline- and noradrenaline-storing cells treated with 3-AP one day previously had lost almost all their granules. A large number of lipoid droplets appeared in the cytoplasm. At the same time, the concentrations of adrenaline and noradrenaline cells were significantly decreased below control values (P less than 0.01). However, these significant changes were ameliorated 19 days after 3-AP treatment. Morphologically and biochemically, the adrenaline- and noradrenaline-storing cells had recovered completely at 35 days.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of 3-acetylpyridine on the adrenal medulla of the mouse

Shimada

Ozaki

1984

J. Neural Transmission

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“…15, 211. However, 3-AP produces lesions in other brain regions which do not exhibit metabolic rates as great as the hippocampus [26], leaving unexplained the basis for the selective nature of 3-AP neurotoxicity.…”

Section: Nadp-dependent Metabolic Pathways After Incorporationmentioning

confidence: 99%

3‐Acetylpyridine‐induced degeneration in the dorsal root ganglia: involvement of small diameter neurons and influence of axotomy

Beiswanger

Roscoe-Graessle

Zerbe

et al. 1993

Neuropathology Appl Neurobio

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3-Acetylpyridine (3-AP), an analogue of nicotinamide, produces highly selective CNS lesions, the severity of which may be influenced by prior alterations in the metabolic activity of the affected neurons. The present study was undertaken to determine whether prior axotomy modified the response of dorsal root ganglia (DRG) and anterior horn (AH) neurons to 3-AP. A single administration (50 or 80 mg/kg i.p.) of 3-AP to adult rats resulted in degeneration of primarily small-dark DRG neurons by 24 h. The AH neurons were not affected by either dose of 3-AP. Light and electron microscopy of the DRG revealed a spectrum of damage ranging from loss of Nissl substance and cytoplasmic degradation to frank necrosis with neuronophagia. Frequently, injured neurons exhibited perinuclear aggregation of cytoplasmic organelles with dissolution of Nissl substance, clearing of the peripheral cytoplasm, and formation of large peripheral vacuoles. Occasionally, a second pattern of 3-AP injury was observed in which the nuclear chromatin of the neurons was condensed and there was formation of small vacuoles throughout the cytoplasm without peripheral clearing or perinuclear aggregation of cytoplasmic organelles. Axotomy induced typical axon reactions in both large-pale and small-dark DRG neurons. The combination of axotomy followed by 3-AP 4 days later produced morphological features characteristic of both axotomy and 3-AP exposure, but did not appear to alter the incidence of neuronal cell death. The almost exclusive vulnerability of the small dorsal root ganglion neurons to 3-AP neurotoxicity make this model potentially useful for the study of small fibre neuropathies.

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Alterations of the nucleus ruber in 3-acetylpyridine intoxication

Cited by 2 publications

References 15 publications

Effects of 3-acetylpyridine on the adrenal medulla of the mouse

Effects of 3-acetylpyridine on the adrenal medulla of the mouse

3‐Acetylpyridine‐induced degeneration in the dorsal root ganglia: involvement of small diameter neurons and influence of axotomy

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