Alterations of the Fine Structure and Androgen Secretion of the Interstitial Cells in the Experimentally Cryptorchid Rat Testis

Mitotic activity in monkey and rat Leydig cells

“…It is also believed that Leydig cells are able to divide (Christensen, 1975). Certainly, interstitial cells show mitotic activity during normal development (Roosen-Runge and Anderson, 1959 ;Baillie, 1961 ;Hitzeman, 1962 ;Gondos et al, 1977) and this activity increases during various experimental conditions (Chemes et al, 1976 ;Aoki and Fawcett, 1978 ;Kerr et al, 1979 ;Christensen and Peacock, 1980). However, mitotic Leydig cells have been actually identified only in cryptorchid rats (Kerr et al, 1979).…”

“…Certainly, interstitial cells show mitotic activity during normal development (Roosen-Runge and Anderson, 1959 ;Baillie, 1961 ;Hitzeman, 1962 ;Gondos et al, 1977) and this activity increases during various experimental conditions (Chemes et al, 1976 ;Aoki and Fawcett, 1978 ;Kerr et al, 1979 ;Christensen and Peacock, 1980). However, mitotic Leydig cells have been actually identified only in cryptorchid rats (Kerr et al, 1979). On the other hand, studies on tritiated thymidine incorporation in young rats have shown either labeled (Niemi and Kormano, 1964 ;Okada, 1970) or unlabeled (Orth, 1982) (Fouquet and Raynaud, 1985 previously by light microscope radioautography (Fouquet and Raynaud, 1985) were re-examined by electron microscope radioautography as well.…”

“…A number of experimental models have been developed in rats, inducing either Leydig cell hyperplasia (Chemes et al, 1976 ;Aoki and Fawcett, 1978 ;Kerr et al, 1979 ;Christensen and Peacock, 1980) or destruction followed by extensive regeneration (Kerr et al, 1985b ;Morris et al, 1986 ;Jackson et al, 1986 ;Risbridger et al, 1987 (Orth, 1982) …”

Androgen secretion and characteristics of testicular hCG binding in cryptorchid rats

“…Induced cryptorchidism in rats results in testicular damage which is accompanied by increased circulating levels of LH and FSH (Swerdloff, Walsh, Jacobs & Odell, 1971; Rager, Zarzychi, Eichner & Gupta, 1975;Gomes & Jain, 1976; Kretser, Sharpe & Swanston, 1979;Kerr, Rich & de . Similar responses are obtained after heat treatment of the testes (Aafjes, Vreeburg & Schenck, 1978).…”

A reinvestigation of hypothalamic-pituitary testicular interactions : simultaneous changes in tissue and plasma levels of gonadotrophins, prolactin, testosterone and hypothalamic LH-RH after bilateral orchidectomy and cryptorchidism

“…Moreover, plasma gonadotrophin levels are increased shortly after surgery (Amatayakul et al, 1971 ;Gomes and Jain, 1976) Kerr, Rich and de Kretser (1979) found these levels depressed by about 50 p. 100 from day 7 to day 8 after surgery, while Gomes and Jain (1976) and Hopkinson et al (1979) found the levels were unchanged for 30 days. Furthermore, at 30 days, the seminal vesicle weights were not lower (Amatayakul et al, 1971 ;Gomes and Jain, 1976 LH-RH content was estimated by a specific radioimmunoassay (Caratyet al,1980).…”