Alterations of striatal phosphodiesterase 10 A and their association with recurrence rate in bipolar I disorder
Yasunori Sano,
Yasuharu Yamamoto,
Manabu Kubota
et al.
Abstract:Phosphodiesterase 10 A (PDE10A), a pivotal element of the second messenger signaling downstream of the dopamine receptor stimulation, is conceived to be crucially involved in the mood instability of bipolar I disorder (BD-I) as a primary causal factor or in response to dysregulated dopaminergic tone. We aimed to determine whether striatal PDE10A availability is altered in patients with BD-I and assessed its relationship with the clinical characteristics of BD-I. This case-control study used positron emission t… Show more
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