Alterations of serum lipid levels and their biological relevances during and after pregnancy

Chiang, An-Na; Yang, Mei-Due; Hung, Joe; Chou, Paula J.; Shyn, S K; Ng, H T

doi:10.1016/0024-3205(95)00230-4

Cited by 139 publications

(28 citation statements)

References 37 publications

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“…Some earlier studies reported that the striking changes in the lipid profile in normal pregnancy is serum hypertriglyceridemia, which may be as high as two to three folds in the third trimester over the levels in non pregnant women. 7 In our study also this observation holds true and the rise in serum triglycerides was statistically significant (P<0.001) in eclampsia patients when compared to women with normal pregnancy.…”

Section: Discussionsupporting

confidence: 82%

Abnormal Lipid levels as a risk factor of eclampsia, study conducted in tertiary care Hospitals of Khyber Pakhtunkhwa Province - Pakistan

Nazli¹,

Khan²,

Akhtar³

et al. 2013

Pak J Med Sci

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Objective: To evaluate abnormal lipid metabolism as a risk factor of eclampsia in pregnant women. Methods: This cross sectional study was conducted in three tertiary care hospitals of Peshawar. Serum total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), triglyceride (TG), apolipoprotein A1 (APO-A1), APO-B100, lipoprotein-a (Lpa) were measured in 110 women with eclampsia and compared with 90 healthy pregnant women. Mean lipid levels in cases and controls were compared using student’s t test”. Results: Mean systolic/diastolic blood pressure, TC, TG, VLDL-C and Lpa levels were significantly higher (p<0.001) in patients compared to control women. Similarly TC: HDL-C, LDL-C: HDL-C and TG: HDL-C ratio in the patients group were significantly higher (p<0.001) and HDL-C: VLDL-C ratio was significantly lower (p<0.001) in the patients as compared to control group. Undesirable cholesterol were noted in 35.8% patients, HDL-C in 50.5%, borderline high concentration of LDL-C in 23.6%, high triglycerides levels in 73.2%, undesirable cholesterol ratio in 52.3% and undesirable LDL-C ratio were noted in 82.1% patients of eclampsia. Conclusion: Serum lipids were found significantly higher thus early assessment may be helpful in prevention of complications in the eclampsia patients.

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Section: Discussionsupporting

confidence: 82%

Abnormal Lipid levels as a risk factor of eclampsia, study conducted in tertiary care Hospitals of Khyber Pakhtunkhwa Province - Pakistan

Nazli¹,

Khan²,

Akhtar³

et al. 2013

Pak J Med Sci

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“…On average, maternal plasma lipids increase linearly during pregnancy, from 4.4 g/L at conception to 7.9 g/L at delivery [we averaged total plasma lipid levels during each trimester from data of from Aurell and Cramer (1966), Chiang et al (1995), Mazurkiewicz et al (1994), and van Stiphout et al (1987)]. We assumed a cord plasma lipid concentration of 1.8 g/L (Denkins et al 2000) to calculate cord plasma PCB-153 levels from fetal lipid PCB-153 at delivery.…”

Section: Methodsmentioning

confidence: 99%

Is the Relationship between Prenatal Exposure to PCB-153 and Decreased Birth Weight Attributable to Pharmacokinetics?

Verner

McDougall

Glynn

et al. 2013

Environ Health Perspect

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Background: A recent meta-analysis based on data from > 7,000 pregnancies reported an association between prenatal polychlorinated biphenyl (PCB)–153 exposure and reduced birth weight. Gestational weight gain, which is associated negatively with PCB levels in maternal and cord blood, and positively with birth weight, could substantially confound this association.Objective: We sought to estimate the influence of gestational weight gain on the association between PCB-153 exposure and birth weight using a pharmacokinetic model.Methods: We modified a recently published pharmacokinetic model and ran Monte Carlo simulations accounting for variability in physiologic parameters and their correlations. We evaluated the pharmacokinetic model by comparing simulated plasma PCB-153 levels during pregnancy to serial measurements in 10 pregnant women from another study population. We estimated the association between simulated plasma PCB-153 levels and birth weight using linear regression models.Results: The plasma PCB-153 level profiles generated with the pharmacokinetic model were comparable to measured levels in 10 pregnant women. We estimated a 118-g decrease in birth weight (95% CI: –129, –106 g) for each 1-μg/L increase in simulated cord plasma PCB-153, compared with the 150-g decrease estimated based on the previous meta-analysis. The estimated decrease in birth weight was reduced to –6 g (95% CI: –18, 6 g) when adjusted for simulated gestational weight gain.Conclusion: Our findings suggest that associations previously noted between PCB levels and birth weight may be attributable to confounding by maternal weight gain during pregnancy.Citation: Verner MA, McDougall R, Glynn A, Andersen ME, Clewell HJ III, Longnecker MP. 2013. Is the relationship between prenatal exposure to PCB-153 and decreased birth weight attributable to pharmacokinetics? Environ Health Perspect 121:1219–1224; http://dx.doi.org/10.1289/ehp.1206457

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“…The increase in serum lipids during pregnancy has been shown in previous research [10–13] with one group of researchers finding that a mother’s serum cholesterol concentrations rise by approximately 50–70% during pregnancy compared to normal concentrations [27]. Others have reported that, compared to non-pregnant women, estimated total cholesterol concentrations increase up to 39% in late pregnancy and triglyceride concentrations may be anywhere up to 138% higher than non-pregnant concentrations in late pregnancy [12]. Evidence has shown that blood lipids revert to pre-pregnancy levels after delivery which suggests that the elevated serum lipids could play an important role in fetal development [12,13,27].…”

Section: Discussionmentioning

confidence: 91%

“…Others have reported that, compared to non-pregnant women, estimated total cholesterol concentrations increase up to 39% in late pregnancy and triglyceride concentrations may be anywhere up to 138% higher than non-pregnant concentrations in late pregnancy [12]. Evidence has shown that blood lipids revert to pre-pregnancy levels after delivery which suggests that the elevated serum lipids could play an important role in fetal development [12,13,27]. …”

Section: Discussionmentioning

confidence: 99%

Maternal Blood Lipid Profile during Pregnancy and Associations with Child Adiposity: Findings from the ROLO Study

et al. 2016

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BackgroundThe in-utero environment affects fetal development; it is vital to understand how maternal diet during pregnancy influences childhood body composition. While research indicates that triglycerides in hyperglycaemic women may increase birth weight, little is known about this relationship in euglycemic women. This study examines the relationship between maternal blood lipid status and infant adiposity up to 2 years of age.MethodsData from 331 mother-child pairs from the ROLO longitudinal birth cohort study was analysed. Maternal dietary intakes were recorded and fasting blood lipids, leptin and HOMA were measured in early and late pregnancy and cord blood. Infant anthropometric measurements and skin-fold thicknesses were recorded at birth, 6 months and 2 years. Correlation and regression analyses were used to explore associations between maternal blood lipid status and infant adiposity.ResultsAll maternal blood lipids increased significantly during pregnancy. Maternal dietary fat intake was positively associated with total cholesterol levels in early pregnancy. Late pregnancy triglycerides were positively associated with birth weight (P = 0.03) while cord blood triglycerides were negatively associated with birth weight (P = 0.01). Cord HDL-C was negatively associated with infant weight at 6 months (P = 0.005). No other maternal blood lipids were associated with infant weight or adiposity up to 2 years of age.ConclusionMaternal and fetal triglycerides were associated with birth weight and cord HDL-C with weight at 6 months. Thus, maternal lipid concentrations may exert in-utero influences on infant body composition. There may be potential to modulate infant body composition through alteration of maternal diet during pregnancy.

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Alterations of serum lipid levels and their biological relevances during and after pregnancy

Cited by 139 publications

References 37 publications

Abnormal Lipid levels as a risk factor of eclampsia, study conducted in tertiary care Hospitals of Khyber Pakhtunkhwa Province - Pakistan

Abnormal Lipid levels as a risk factor of eclampsia, study conducted in tertiary care Hospitals of Khyber Pakhtunkhwa Province - Pakistan

Is the Relationship between Prenatal Exposure to PCB-153 and Decreased Birth Weight Attributable to Pharmacokinetics?

Maternal Blood Lipid Profile during Pregnancy and Associations with Child Adiposity: Findings from the ROLO Study

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