Alterations of regional spontaneous brain activity in obsessive-compulsive disorders: A meta-analysis

Li, Huayun; Wang, Yihe; Xi, Hongyu; Zhang, Jianxin; Zhao, Mengqi; Jia, Xize

doi:10.1016/j.jpsychires.2023.07.036

Cited by 4 publications

(2 citation statements)

References 93 publications

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“…It is associated with cognitive functions, such as response inhibition and flexibility ( 58 ), and emotion regulation ( 59 ). A recent rs-fMRI meta-analysis demonstrated lower left caudate activation in OCD vs. HC ( 60 ). This finding was consistent with our study, indicating reduced flexibility of response in OCD patients.…”

Section: Discussionmentioning

confidence: 99%

Convergent functional change of frontoparietal network in obsessive-compulsive disorder: a voxel-based meta-analysis

Yu,

Xu,

et al. 2024

Front. Psychiatry

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BackgroundObsessive-compulsive disorder (OCD) is a chronic psychiatric illness with complex clinical manifestations. Cognitive dysfunction may underlie OC symptoms. The frontoparietal network (FPN) is a key region involved in cognitive control. However, the findings of impaired FPN regions have been inconsistent. We employed meta-analysis to identify the fMRI-specific abnormalities of the FPN in OCD.MethodsPubMed, Web of Science, Scopus, and EBSCOhost were searched to screen resting-state functional magnetic resonance imaging (rs-fMRI) studies exploring dysfunction in the FPN of OCD patients using three indicators: the amplitude of low-frequency fluctuation/fractional amplitude of low-frequency fluctuation (ALFF/fALFF), regional homogeneity (ReHo) and functional connectivity (FC). We compared all patients with OCD and control group in a primary analysis, and divided the studies by medication in secondary meta-analyses with the activation likelihood estimation (ALE) algorithm.ResultsA total of 31 eligible studies with 1359 OCD patients (756 men) and 1360 healthy controls (733 men) were included in the primary meta-analysis. We concluded specific changes in brain regions of FPN, mainly in the left dorsolateral prefrontal cortex (DLPFC, BA9), left inferior frontal gyrus (IFG, BA47), left superior temporal gyrus (STG, BA38), right posterior cingulate cortex (PCC, BA29), right inferior parietal lobule (IPL, BA40) and bilateral caudate. Additionally, altered connectivity within- and between-FPN were observed in the bilateral DLPFC, right cingulate gyrus and right thalamus. The secondary analyses showed improved convergence relative to the primary analysis.ConclusionOCD patients showed dysfunction FPN, including impaired local important nodal brain regions and hypoconnectivity within the FPN (mainly in the bilateral DLPFC), during the resting state. Moreover, FPN appears to interact with the salience network (SN) and default mode network (DMN) through pivotal brain regions. Consistent with the hypothesis of fronto-striatal circuit dysfunction, especially in the dorsal cognitive circuit, these findings provide strong evidence for integrating two pathophysiological models of OCD.

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Section: Discussionmentioning

confidence: 99%

Convergent functional change of frontoparietal network in obsessive-compulsive disorder: a voxel-based meta-analysis

Yu,

Xu,

et al. 2024

Front. Psychiatry

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“…We know about its role in such activities as speech, language acquaintance, reading, operational memory storage and word comprehension. [1] It was proven that this area can take partial responsibility for obsessive-compulsive disorder by its intensive spontaneous activity [2], or the occurrence of dyslexia. [3] Angular gyrus is supplied by the angular gyrus artery (AGA)-one of the final cortical branches of the middle cerebral artery (MCA).…”

Section: Introductionmentioning

confidence: 99%

Anatomical variations of artery of angular gyrus

Niemiec,

Guzowicz,

Bluczak

et al. 2024

J Educ Health Sport

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Context: Angular gyrus is an anatomical structure of the brain located in the parietal lobe, taking part in writing and reading, language-use, memory and attention and spatial recognition. It is supplied by the angular gyrus artery, which is one of the caudal branches of the middle cerebral artery. One of the clinical pathologies of the angular gyrus artery is the ischemic stroke of the angular gyrus in the dominant hemisphere, responsible for the presence of Gerstmann Syndrome: left-right disorientation, agraphia, alexia, acalculia and finger agnosia. This systematic review aims to present the variety of anomalies of the main cerebral artery and the angular gyrus artery. Objective: Preparing a systematic review of papers describing the course anomalies of the angular gyrus artery. Materials and methods: PubMed and Google Scholar electronic databases was searched for phrases: ‘Angular gyrus artery’, ‘Artery of angular gyrus’, ‘Middle cerebral artery branches’, ‘Branches of middle cerebral artery’, ‘Gerstmann Syndrome’ published between years 2015 and 2023. Also 3 papers published before 2000 were used. From the selected 30 papers, 6 were used to prepare this analysis. Results: The middle cerebral artery, from which arises the angular gyrus artery, is marked by a significant variety of its division, mainly the number of the dividing trunks of the artery. Depending on the type of the division, the angular gyrus artery can arise from the upper, middle or lower trunk and vary in sizes. It can also appear as a singular or two separate branches. Instances of the anomaly of both the angular gyrus artery and posterior parietal artery are rare, but reported. Conclusions: The angular gyrus artery is characterised by a number of anomalies in its course, separation from the middle cerebral artery, diameter and branching.

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Association between clinical features and decreased degree centrality and variability in dynamic functional connectivity in the obsessive–compulsive disorder

Teng,

Zhang,

Zhang

et al. 2024

NeuroImage: Clinical

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Alterations of regional spontaneous brain activity in obsessive-compulsive disorders: A meta-analysis

Cited by 4 publications

References 93 publications

Convergent functional change of frontoparietal network in obsessive-compulsive disorder: a voxel-based meta-analysis

Convergent functional change of frontoparietal network in obsessive-compulsive disorder: a voxel-based meta-analysis

Anatomical variations of artery of angular gyrus

Association between clinical features and decreased degree centrality and variability in dynamic functional connectivity in the obsessive–compulsive disorder

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