Alterations of platelet function, number and indexes during acute pancreatitis

Mimidis, Konstantinos; Papadopoulos, Vassilios; Kotsianidis, J.; Filippou, Dimitrios; Spanoudakis, Emmanuil; Bourikas, Georgios; Dervenis, Christos; Kartalis, G

doi:10.1159/000077024

Cited by 58 publications

(61 citation statements)

References 16 publications

(20 reference statements)

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“…It is reported that increased MPV is associated with Crohn's disease, rheumatoid arthritis, familial Mediterranean fever, ulcerative colitis, acute pancreatitis, ischemic stroke, diabetes mellitus, and myocardial infarction. In recent years, MPV has been considered a simple marker for inflammation in inflammatory disorders [12][13][14][15][16][17]. In a study on Behcet's disease, the MPV value was found to be significantly higher in the Behcet group compared to controls and it was reported to be associated with predisposition to thrombosis [18].However, in our study, no significant difference was found in MPV value in patients with gout.…”

Section: Discussioncontrasting

confidence: 75%

Neutrophil: Lymphocyte Ratio and Mean Platelet Volume in Patients with Gout

Balkarlı¹

2017

Ann Clin Anal Med

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ÖzetAmaç: Gut artmış ürik asit konsantrasyonu ile birlikte monosodyum ürat (MSU) kristallerine karşı oluşan inflamatuar yanıtın yol açtığı klinik bir sendromdur. Gut hastalığında inflamatuar yanıtın oluşmasında nötrofiller önem-lidir ve nötrofil aktivasyonu lokal olarak üretilen sitokinlere bağlıdır. Ortalama trombosit hacmi (MPV) ve nötrofil lenfosit oranı (NLR) bazı hastalıklarda inflamatuar belirteç olarak değerlendirilmiş ve prognostik öneme sahip olabileceği bildirilmiştir. Bildiğimiz kadarıyla literatürde gut hastalığında MPV ve/ veya N/L oranının değerlendirildiği bir çalışma yoktur. Biz bu retrospektif ça-lışmamızda gut hastalığında inflamasyonun belirlenmesinde MPV ve NLR' nin rolünü araştırdık. Gereç ve Yöntem: Retrospektif olarak dizayn edilmiş olan bu çalışmaya gut hastalarının dosyaları taranarak çalışmaya dahil edilme kriterlerini karşılayan toplam 106 ( 91 erkek, 15 kadın) gut hastası ve yaş-cinsiyet eşleştirmeli 148 ( 128 erkek, 20 kadın) sağlıklı kontrol grubu alındı. Hasta grubunun atak dönemi (Grup I) ve ataksız dönemi (grup II) laboratuvar verileri toplandı. Bulgular: Gut hasta grubu yaş ortalaması 59.46±12.93 yıl, sağlık-lı kontrol grubu yaş ortalaması 59±11.33 yıl idi. Her iki grup yaş ve cinsiyet açısından benzerdi. İlk atak yaşı 52±12.77 yıl, ilk iki atak arası süre 6±5.52 ay idi. Hastaların 9'unda (%8.5) tofüs, 17'sinde (%16) gut aile öyküsü vardı. MPV her üç grupta da benzerdi. CRP ve eritrosit sedimentasyon hızı, atak dönem gut hasta grubunda ataksız dönem gut hasta grubuna göre istatistiksel anlamlı yüksek saptandı. N/L oranı her üç grupta da istatistiksel olarak anlamlı farklılık gösteriyordu. Tofüs varlığına göre hastalar sınıflandırıldığında ise her iki grupta da MPV ve N/L oranının benzer olduğu görüldü. Tartışma: N/L oranı hem atak hem ataksız dönem gut hastalarında sağlıklı kontrol grubuna göre artmıştı. Bu çalışma gut hastalarının kronik inflamasyona maruz kaldı-ğını göstermektedir. Bu nedenle N / L oranı gut hastalığında inflamasyonun gösterilmesinde basit, ucuz ve kullanışlı tanısal belirteç olabilir. Anahtar KelimelerGut; Nötrofillenfositoranı; Ortalama Trombosit Hacmi Abstract Aim: Gout is a clinical syndrome with increased uric acid concentration, which is caused by inflammatory response against monosodium urate (MSU) crystals. In gout, neutrophils are involved in inflammatory response and neutrophil activation is dependent on local cytokine production. Mean platelet volume (MPV) and neutrophillymphocyte ratio (NLR) are considered as inflammatory markers in several diseases and it is reported that they may have prognostic significance. Inthe current literature, there is no study evaluating MPV and NLR in gout. In this retrospective study, we investigated the role of MPV and NLR in determining inflammation in gout disease. Material and Method: In this retrospective study, 106 patients with gout (91 men and 15 women) meeting the inclusion criteria based on patient records and 148 ageand sex-matched healthy controls (128 men and 20 women) were included. Laboratory data during...

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Section: Discussioncontrasting

confidence: 75%

Neutrophil: Lymphocyte Ratio and Mean Platelet Volume in Patients with Gout

Balkarlı¹

2017

Ann Clin Anal Med

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“…In rabbits, administration of pancreatic fluid from patients with chronic pancreatitis induced platelet aggregation and activation (Prinz et al, 1984). In cases of acute pancreatitis, platelets have been shown to be activated, and their indices (mean platelet volume, platelet large cell ratio, and platelet distribution width) have also been shown to be elevated between onset and remission of AP (Mimidis et al, 2004). While a heightened platelet response is typical of patients with mild AP, a decreased platelet count (due to increased consumption of platelets) is observed in cases of severe AP.…”

Section: Introductionmentioning

confidence: 99%

Coagulation Abnormalities in Acute Pancreatitis

Gould¹,

Mai²,

Liaw³

2012

Pancreatitis - Treatment and Complications

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“…[21][22][23][24][25][26] In recent years, several studies have reported that MPV may be used as marker of inflammation in several disorders. [11][12][13][14][15][16] Sansanayudh et al [27] investigated 40 studies in a systematic review and meta-analysis comparing mean differences in high versus low MPV between patients with coronary artery disease (CAD). They reported that patients with CAD and patients with slow coronary blood flow had larger MPV compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

“…[10] Increased platelet activation plays an active role in the development of inflammation. [11][12][13][14][15][16][17][18] It was found that platelets significantly contribute to the inflammatory process, such that platelet indices, including mean platelet volume (MPV), platelet distribution width (PDW), and platelet count (PC), may be used as an index for inflammatory conditions caused by autoimmune conditions or infection. [11][12][13][14][15][16][17][18] Sometimes, it may be difficult to diagnose patients with DNSI early during the course of acute tonsillitis.…”

mentioning

confidence: 99%

Evaluation of platelet indices in patients with deep neck space infection as a complication of acute tonsillitis

Binnetoğlu¹,

Yumuşakhuylu²,

Bağlam³

et al. 2017

Kulak Burun Bogaz Ihtis Derg

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Objectives: This study aims to evaluate whether platelet indices are helpful to identify deep neck space infections (DNSIs) secondary to acute tonsillitis. Patients and Methods:A total of 321 patients diagnosed with acute tonsillitis with or without DNSI admitted to the Otolaryngology Department of Marmara University Pendik Training and Research Hospital between August 2010 and January 2014 were retrospectively reviewed. Patients underwent full otolaryngologic examination and radiological imaging studies including computed tomography (CT) or magnetic resonance imaging (MRI) in cases of suspected DNSI. Mean platelet volume (MPV), platelet distribution width (PDW), and platelet count (PC) were calculated in all subjects and these were compared between the patients with or without DNSI secondary to acute tonsillitis. Results:With respect to DNSI complications of tonsillitis, 25 of the patients had peritonsillar abscesses (7.8%), 11 had parapharyngeal abscesses (3.4%), and six had retropharyngeal abscesses (1.9%). The MPV, PDW, and PC values were significantly higher in patients with acute tonsillitis and DNSI (p<0.05). The optimum cut-off values for MPV, PDW, and PC were 8.75, 16.65, 278 and 500, respectively. Conclusion:This study is the first to evaluate the relationship between platelet indices and DNSI complications of acute tonsillitis. Our results demonstrate that MPV, PDW, and PC values are potential laboratory parameters for diagnosing DNSIs.Keywords: Acute tonsillitis; deep neck infection; inflammation; mean platelet volume; platelets; platelet distribution width. Sonuç: Bu çalışma, akut bademcik iltihabının trombosit indeksleri ile DBE komplikasyonları arasındaki ilişkiyi değerlendiren ilk çalışmadır. Sonuçlarımız, OTH, TDG ve PC değerlerinin DBE tanısında potansiyel laboratuvar parametrelerini göstermektedir.Anahtar Sözcükler: Akut bademcik iltihabı; derin boyun enfeksiyonu; enflamasyon; ortalama trombosit hacmi; trombosit; trombosit dağılım genişliği.

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Alterations of platelet function, number and indexes during acute pancreatitis

Cited by 58 publications

References 16 publications

Neutrophil: Lymphocyte Ratio and Mean Platelet Volume in Patients with Gout

Neutrophil: Lymphocyte Ratio and Mean Platelet Volume in Patients with Gout

Coagulation Abnormalities in Acute Pancreatitis

Evaluation of platelet indices in patients with deep neck space infection as a complication of acute tonsillitis

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