Alterations of oncogenes expression in NK cells in patients with cancer

Zakiryanova, Gulnur K.; Kustova, Elena; Urazalieva, Nataliya T.; Amirbekov, Aday; Baimuchametov, Emile T.; Nakisbekov, Narymzhan N.; Shurin, Michael R.

doi:10.1002/iid3.179

Cited by 13 publications

(16 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present studies have revealed that mast cells have a pro-tumor or anti-tumor role depending on the type of cancer, the degree of tumor progression, and the location of these immune cells in the tumor site [43]. The natural killer (NK) cells were discovered for their ability to rapidly recognize and efficiently kill tumor cells [44], and to release a number of cytokines that regulate both innate and adaptive immune responses [45]. The infiltration of NK cells in TME was associated with improved prognosis in triple-negative breast cancer [46] and colorectal cancer [47].…”

Section: Discussionmentioning

confidence: 99%

Profiles of immune cell infiltration in head and neck squamous carcinoma

Liang

Wang

2020

Bioscience Reports

View full text Add to dashboard Cite

Tumor immune infiltration cells (TIICs) are highly heterogeneous, not only in different cancer subtypes but also within different cancer regions. We conducted the Cell-type Identification using Estimating Relative Subsets Of RNA Transcripts (CIBERSORT) method. We assessed the relative proportions of 22 TIICs in HNSC using publicly available TCGA transcriptional datasets, analyzed the proportions of TIICs between HNSC tissues and normal tissues, along with accompanying clinicopathological data, and the impact of TIICs on clinical outcome. After the filter criteria, a total of 395 patients were included in the analysis. We found significant differences in naïve B cells, monocytes, resting mast cells, activated mast cells, CD8+ T cells, and M0 macrophages between HNSC tissues and adjacent non-cancer tissues. We also found that some TIIC subgroups were significantly associated with clinical parameters. Moreover, the patients with low Tregs fraction had worse OS and DFS than those with high Tregs fraction. However, low M0 macrophages fraction was associated with better OS and DFS in HNSC patients. Moreover, Tregs and M0 macrophages are likely to be important determinants of prognosis, which may serve as a potential immunotherapy target for HNSC. Then, we screened the immune-related differentially expressed genes (DEGs), performed the GO and KEGG enrichment analysis, constructed the protein–protein interaction network, and screened the prognosis-related hub genes in HNSC. However, further clinical investigation and basic experiments are needed to validate our results, and uncover the molecular mechanisms interlinking TIICs in HNSC and their roles in prognosis and therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Profiles of immune cell infiltration in head and neck squamous carcinoma

Liang

Wang

2020

Bioscience Reports

View full text Add to dashboard Cite

show abstract

“…c-Myc expression was significantly decreased in NK cells in all cancer patients independently of tumor location, stage of disease or the presence of metastases. 73 Marked changes in the expression of other oncogenes, such as c-kit, STAT3 and soluble and membrane-bound forms of ligand for c-kit/stem cell factor (SCF), were also found in these NK cells. c-Kit expression in NK cells was significantly decreased in all patients.…”

Section: Oncogenes and Transcription Factors As Regulators Of Immune mentioning

confidence: 99%

“…Expression of SCF had a clear tendency to be decreased, as well as c-kit did. 73 Alterations of the c-kit/SCF autocrine loop in NK cells in cancer seem indicated. In contrast, STAT3 expression in NK cells was significantly increased in lung cancer patients compared to healthy control donors.…”

Section: Oncogenes and Transcription Factors As Regulators Of Immune mentioning

confidence: 99%

Oncogenes in immune cells as potential therapeutic targets

Zakiryanova

Wheeler

Shurin

2018

ITT

View full text Add to dashboard Cite

The role of deregulated expression of oncogenes and tumor-suppressor genes in tumor development has been intensively investigated for decades. However, expression of oncogenes and their potential role in immune cell defects during carcinogenesis and tumor progression have not been thoroughly assessed. The defects in proto-oncogenes have been well documented and evaluated mostly in tumor cells, despite the fact that proto-oncogenes are expressed in all cells, including cells of the immune system. In this review, key studies from immune-mediated diseases that may be associated with oncogene signaling pathways are refocused to provide groundwork for beginning to understand the effects of oncogenes in and on the cancer-related immune system dysfunction.

show abstract

“…Commercially available NanoFlares have also been used successfully by a number of groups for studying genetic content in live cells …”

Section: Hybridization‐based Probesmentioning

confidence: 99%

Nucleic‐Acid Structures as Intracellular Probes for Live Cells

2019

View full text Add to dashboard Cite

The chemical composition of cells at the molecular level determines their growth, differentiation, structure, and function. Probing this composition is powerful because it provides invaluable insight into chemical processes inside cells and in certain cases allows disease diagnosis based on molecular profiles. However, many techniques analyze fixed cells or lysates of bulk populations, in which information about dynamics and cellular heterogeneity is lost. Recently, nucleic‐acid‐based probes have emerged as a promising platform for the detection of a wide variety of intracellular analytes in live cells with single‐cell resolution. Recent advances in this field are described and common strategies for probe design, types of targets that can be identified, current limitations, and future directions are discussed.

show abstract

Alterations of oncogenes expression in NK cells in patients with cancer

Cited by 13 publications

References 49 publications

Profiles of immune cell infiltration in head and neck squamous carcinoma

Profiles of immune cell infiltration in head and neck squamous carcinoma

Oncogenes in immune cells as potential therapeutic targets

Nucleic‐Acid Structures as Intracellular Probes for Live Cells

Contact Info

Product

Resources

About