Alterations of mRNAs and Non-coding RNAs Associated with Neuroinflammation in Alzheimer’s Disease

Hernández-Contreras, Karla Aketzalli; Martínez-Díaz, Jorge Antonio; Hernández-Aguilar, María Elena; Herrera-Covarrubias, Deissy; Rojas-Durán, Fausto; Chi-Castañeda, Lizbeth Donají; García- Hernández, Luis Isauro; Aranda-Abreu, Gonzalo Emiliano

doi:10.1007/s12035-023-03908-5

Cited by 3 publications

(2 citation statements)

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“… 39 piRNA plays a potentially important role in different tissues, such as liver, heart, retinal cells, retinal pigment epithelial cells and peripheral blood. 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 These findings not only expand our understanding of the function of piRNAs but also provide new perspectives and possibilities for the study of related diseases. piRNA has high stability in serum and can maintain its integrity even under the influence of the external environment.…”

Section: Pirna Functions and Related Mechanismsmentioning

confidence: 76%

Recent advances of PIWI‐interacting RNA in cardiovascular diseases

Li,

Wang,

Cheng

et al. 2024

Clinical & Translational Med

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BackgroundThe relationship between noncoding RNAs (ncRNAs) and human diseases has been a hot topic of research, but the study of ncRNAs in cardiovascular diseases (CVDs) is still in its infancy. PIWI‐interacting RNA (piRNA), a small ncRNA that binds to the PIWI protein to maintain genome stability by silencing transposons, was widely studied in germ lines and stem cells. In recent years, piRNA has been shown to be involved in key events of multiple CVDs through various epigenetic modifications, revealing the potential value of piRNA as a new biomarker or therapeutic target.ConclusionThis review explores origin, degradation, function, mechanism and important role of piRNA in CVDs, and the promising therapeutic targets of piRNA were summarized. This review provide a new strategy for the treatment of CVDs and lay a theoretical foundation for future research.Key points piRNA can be used as a potential therapeutic target and biomaker in CVDs. piRNA influences apoptosis, inflammation and angiogenesis by regulating epigenetic modificaions. Critical knowledge gaps remain in the unifying piRNA nomenclature and PIWI‐independent function.

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Section: Pirna Functions and Related Mechanismsmentioning

confidence: 76%

Recent advances of PIWI‐interacting RNA in cardiovascular diseases

Li,

Wang,

Cheng

et al. 2024

Clinical & Translational Med

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“…MicroRNAs (miRNAs) are small RNA molecules that control gene expression by suppressing or degrading messenger RNAs (mRNA) that are involved in protein production ( Hernández-Contreras et al, 2024 ). Research indicates that the majority of coding proteins are influenced by miRNAs.…”

Section: Introductionmentioning

confidence: 99%

Investigating the potential neuroprotective benefits of taurine and Dihydrotestosterone and Hydroxyprogesterone levels in SH-SY5Y cells

Almohaimeed,

Almars,

Alsulaimani

et al. 2024

Front. Aging Neurosci.

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BackgroundTaurine, an amino acid abundantly found in the brain and other tissues, has potential neuroprotective properties. Alzheimer’s disease (AD) is a commonly occurring type of dementia, which becomes more prevalent as people age. This experiment aimed to assess the neuroprotective effects of taurine on SH-SY5Y cells by examining its impact on Dihydrotestosterone (DHT), Dihydroprogesterone (DHP), as well as the expression of miRNA-21 and miRNA-181.MethodsThe effects of various taurine concentrations (0.25, and 0.75 mg/mL), and LPS (0.1, and 12 mg/mL) on the SH-SY5Y cell line were assessed using the MTT assay. The levels of DHT and DHP were quantified using an ELISA kit. Additionally, the expression levels of miRNA-181 and miRNA-21 genes were examined through Real-Time PCR analysis.ResultsThe results of the MTT assay showed that treatment with taurine at concentrations of 0.25, and 0.75 mg/mL reduces the toxicity of LPS in SH-SY5Y cells. ELISA results indicated that taurine at a concentration of 0.25, and 0.75 mg/mL significantly elevated DHT and DHP hormones in the SH-SY5Y cell line compared to the untreated group (p < 0.01). The expression levels of IL-1β and IL-6 were decreased under the influence of LPS in SH-SY5Y cells after taurine treatment (p < 0.01). Gene expression analysis revealed that increasing taurine concentration resulted in heightened expression of miRNA-181 and miRNA-21, with the most significant increase observed at a concentration of 0.75 mg/mL (p < 0.001).ConclusionOur study findings revealed that the expression of miRNA-181 and miRNA-21 can be enhanced by taurine. Consequently, exploring the targeting of taurine, miRNA-181, and miRNA-21 or considering hormone therapy may offer potential therapeutic approaches for treating AD or alleviating severe symptoms. Nonetheless, in order to fully comprehend the precise mechanisms involved, additional research is required.

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Exploring the Roles of Key Mediators IKBKE and HSPA1A in Alzheimer’s Disease and Hepatocellular Carcinoma through Bioinformatics Analysis

Wang,

Yang,

Liang

et al. 2024

IJMS

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Recent studies have hinted at a potential link between Alzheimer’s Disease (AD) and cancer. Thus, our study focused on finding genes common to AD and Liver Hepatocellular Carcinoma (LIHC), assessing their promise as diagnostic indicators and guiding future treatment approaches for both conditions. Our research utilized a broad methodology, including differential gene expression analysis, Weighted Gene Co-expression Network Analysis (WGCNA), gene enrichment analysis, Receiver Operating Characteristic (ROC) curves, and Kaplan–Meier plots, supplemented with immunohistochemistry data from the Human Protein Atlas (HPA) and machine learning techniques, to identify critical genes and significant pathways shared between AD and LIHC. Through differential gene expression analysis, WGCNA, and machine learning methods, we identified nine key genes associated with AD, which served as entry points for LIHC analysis. Subsequent analyses revealed IKBKE and HSPA1A as shared pivotal genes in patients with AD and LIHC, suggesting these genes as potential targets for intervention in both conditions. Our study indicates that IKBKE and HSPA1A could influence the onset and progression of AD and LIHC by modulating the infiltration levels of immune cells. This lays a foundation for future research into targeted therapies based on their shared mechanisms.

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Alterations of mRNAs and Non-coding RNAs Associated with Neuroinflammation in Alzheimer’s Disease

Cited by 3 publications

References 125 publications

Recent advances of PIWI‐interacting RNA in cardiovascular diseases

Recent advances of PIWI‐interacting RNA in cardiovascular diseases

Investigating the potential neuroprotective benefits of taurine and Dihydrotestosterone and Hydroxyprogesterone levels in SH-SY5Y cells

Exploring the Roles of Key Mediators IKBKE and HSPA1A in Alzheimer’s Disease and Hepatocellular Carcinoma through Bioinformatics Analysis

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