Alterations of mitochondrial function and correlations with personality traits in selected major depressive disorder patients

Gardner, Ann

doi:10.1016/s0165-0327(02)00067-8

Cited by 253 publications

(162 citation statements)

References 71 publications

Supporting

Mentioning

150

Contrasting

Unclassified

Order By: Relevance

“…Evidence shows that patients with psychiatric disorders (depression, bipolar disorder, and schizophrenia) exhibit mitochondrial abnormalities at the structural, molecular, and functional levels. 22 Indeed, Gardner et al 23 showed a significant decrease in mitochondrial ATP production rates and Figure 1 Effect of prolonged administration of fluvoxamine on citrate synthase activity in the rat prefrontal cortex, hippocampus, striatum, cerebellum, and cerebral cortex. Data were analyzed by one-way analysis of variance followed by Tukey test when F results were significant.…”

Section: Discussionmentioning

confidence: 99%

Fluvoxamine alters the activity of energy metabolism enzymes in the brain

Ferreira

Cardoso

Jeremias

et al. 2014

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

Objective: Several studies support the hypothesis that metabolism impairment is involved in the pathophysiology of depression and that some antidepressants act by modulating brain energy metabolism. Thus, we evaluated the activity of Krebs cycle enzymes, the mitochondrial respiratory chain, and creatine kinase in the brain of rats subjected to prolonged administration of fluvoxamine. Methods: Wistar rats received daily administration of fluvoxamine in saline (10, 30, and 60 mg/kg) for 14 days. Twelve hours after the last administration, rats were killed by decapitation and the prefrontal cortex, cerebral cortex, hippocampus, striatum, and cerebellum were rapidly isolated. Results: The activities of citrate synthase, malate dehydrogenase, and complexes I, II-III, and IV were decreased after prolonged administration of fluvoxamine in rats. However, the activities of complex II, succinate dehydrogenase, and creatine kinase were increased. Conclusions: Alterations in activity of energy metabolism enzymes were observed in most brain areas analyzed. Thus, we suggest that the decrease in citrate synthase, malate dehydrogenase, and complexes I, II-III, and IV can be related to adverse effects of pharmacotherapy, but long-term molecular adaptations cannot be ruled out. In addition, we demonstrated that these changes varied according to brain structure or biochemical analysis and were not dose-dependent.

show abstract

Section: Discussionmentioning

confidence: 99%

Fluvoxamine alters the activity of energy metabolism enzymes in the brain

Ferreira

Cardoso

Jeremias

et al. 2014

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

show abstract

“…A growing body of evidence suggests that bipolar disorder and schizophrenia are illnesses that are particularly associated with mitochondrial dysfunction. [32][33][34][35][36][37] Studies involving brain imaging have shown that adenosine- orders. [32][33][34][35] It has also been reported that the density of mitochondria was decreased in the caudate nucleus and putamen of patients with schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Oxidative damage to RNA but not DNA in the hippocampus of patients with major mental illness

Che

Wang

Shao

et al. 2010

jpn

138

View full text Add to dashboard Cite

Background: Oxidative damage in the central nervous system is increasingly recognized as an important pathological process in many diseases. Previously, our laboratory found that oxidative damage to lipids and proteins was increased in postmortem brain tissue from patients with bipolar disorder and schizophrenia. In the current study, we analyzed oxidative damage to nucleic acids in the CA1, CA3 and dentate gyrus regions of postmortem hippocampus tissue from patients with bipolar disorder, schizophrenia and major depression. Methods: We examined oxidative damage to nucleic acids by performing immunohistochemistry with a monoclonal antibody that recognizes both 8-hydroxy-guanosine in RNA and 8-hydroxy-2'-deoxyguanosine in DNA. Results: We found that the amount of oxidative damage to nucleic acids was elevated in the CA1, CA3 and dentate gyrus regions of the hippocampus among patients with bipolar disorder, schizophrenia and major depressive disorder. This damage was predominantly in the cytoplasm, suggesting that the damage was primarily to RNA. Compared with oxidative damage in control samples, the magnitude of damage was high in patients with schizophrenia, modest in patients with bipolar disorder and lower in patients with major depression. Limitations: The interpretation of our results is limited by a number of factors, including the retrospective review of patient history, the relatively small sample size and the inclusion of patients who had substance abuse and were undergoing various drug treatments at the time of death. Conclusion: Our results suggest that oxidative damage to RNA, rather than to DNA, occurs in vulnerable neurons of the brain in patients with major mental illness and may contribute to the pathology of these disorders. The magnitude of RNA oxidative damage may be associated with the severity of mental illness.

show abstract

“…Depression is associated with mitochondrial dysfunction or disease with evidence of deletions of mitochondrial DNA Boles, 2008a, Shao et al, 2008), and lower activities of respiratory chain enzymes and ATP production (Gardner et al, 2003). Depressed patients presenting with somatic complaints also have low ATP production rates in biopsied muscles Boles, 2008a, Gardner andBoles, 2008b).…”

Section: Mitochondrial Disturbancesmentioning

confidence: 99%

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Lopresti

Hood

Drummond

2013

Journal of Affective Disorders

506

412

View full text Add to dashboard Cite

Research on major depression has confirmed that it is caused by an array of biopsychosocial and lifestyle factors. Diet, exercise and sleep are three such influences that play a significant mediating role in the development, progression and treatment of this condition. This review summarises animal and human-based studies on the relationship between these three lifestyle factors and major depressive disorder, and their influence on dysregulated pathways associated with depression, namely neurotransmitter processes, immuno-inflammatory pathways, hypothalamic-pituitary-adrenal (HPA) axis disturbances, oxidative stress and antioxidant defence systems, neuroprogression, and mitochondrial disturbances. Increased attention in future clinical studies on the influence of diet, sleep and exercise on major depressive disorder and investigations of their effect on physiological processes will help to expand our understanding and treatment of major depressive disorder. Mental health interventions, taking into account the bidirectional relationship between these lifestyle factors and major depression are also likely to enhance the efficacy of interventions associated with this disorder.

show abstract

Alterations of mitochondrial function and correlations with personality traits in selected major depressive disorder patients

Cited by 253 publications

References 71 publications

Fluvoxamine alters the activity of energy metabolism enzymes in the brain

Fluvoxamine alters the activity of energy metabolism enzymes in the brain

Oxidative damage to RNA but not DNA in the hippocampus of patients with major mental illness

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Contact Info

Product

Resources

About