1982
DOI: 10.1007/bf01908175
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Alterations of mechanical parameters in chemically skinned preparations of rat myocardium as a function of isoenzyme pattern of myosin

Abstract: Myofibrillar ATPase activity, maximum unloaded shortening velocity, and isometric tension development were evaluated in left ventricular preparations of 5-week-old rats with a high endogeneous level of thyroid hormones and hypothyroid rats after 4-week treatment with propylthiouracil (PTU). The range of possible alterations of the above functional parameters was defined in relation to myosin isoenzyme distribution. The mechanical behaviour of the ventricular preparations was investigated in native myocardium a… Show more

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Cited by 136 publications
(44 citation statements)
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“…Moreover, hypothyroidism is associated with a great reduction in Vma. (34,35) and AFIs (34,49), which we did not observe in our model.…”
Section: Discussioncontrasting
confidence: 82%
See 1 more Smart Citation
“…Moreover, hypothyroidism is associated with a great reduction in Vma. (34,35) and AFIs (34,49), which we did not observe in our model.…”
Section: Discussioncontrasting
confidence: 82%
“…Under various physiological and pathological conditions, including development (24) and hormonal (26,28) and chronic hemodynamic alterations (25,(29)(30)(31), the relative proportions of these isomyosins change as a result of modifications in the expression of the corresponding genes (32,33). These changes are well correlated with the alterations in the myocardial performance of the different rat and rabbit models so far studied (34)(35)(36)(37)(38).…”
Section: Introductionmentioning
confidence: 98%
“…This completely corresponds to earlier observations that the myosin isoenzyme profile is profoundly affected in hypothyroidism due to downregulation of the ␣-MHC gene that is linked to an increased expression ␤-MHC in both rat and mouse heart (25,29). This molecular switch is known to slow down cardiac contraction (11,17). Note that the found marked increase in ␤-MHC protein levels in hypothyroid hearts did not differ between WT and TG.…”
Section: Discussionsupporting
confidence: 91%
“…These observations allow us to think that a possible increase in the consumption of ATP due to expression of additional SERCA2a molecules coded by the SERCA2 minigene was obviously not associated with a significant energy deficit in hypothyroid TG hearts. Most probably, this can result from an increased economy of ATP utilization due to both the improvement of cellular Ca 2ϩ handling and slowed cross-bridge cycling of ␤-MHC-rich isomyosins with low ATPase activity (11,17) in the latter animals. Thus it appears that the improvement of SR Ca 2ϩ handling by introducing SERCA2a minigene is an energetically favorable treatment for preventing contractile dysfunction in diseased states.…”
Section: Discussionmentioning
confidence: 99%
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