Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder

Itahashi, Takashi; Yamada, Takashi; Watanabe, Hiromi; Nakamura, Motoaki; Ohta, Haruhisa; Kanai, Chieko; Iwanami, Akira; Kato, Nobuo; Hashimoto, Ryuichiro

doi:10.1186/s13229-015-0026-z

Cited by 84 publications

(68 citation statements)

References 93 publications

(122 reference statements)

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“…This further supported our findings that the bilateral pMTG was more vulnerable in both children and adults with ASD than in the TD group, which showed mainly hypoconnectivity with different brain regions. Our findings together with other studies [Itahashi et al, ; Scheel et al, ] highlighted the important role of the pMTG in the neuropathology of ASD.…”

Section: Discussionsupporting

confidence: 89%

“…Moreover, a study using a large sample size of individuals with ASD revealed diminished functional connectivity between the bilateral MTG and cerebellum [Ramos, Balardin, Sato, & Fujita, ]. Individuals with ASD not only exhibited local underconnectivity in the right pMTG, but also showed a significant association between disrupted local connectivity in this region and social interaction [Itahashi et al, ]. However, increased degree centrality in the left MTG [Lee, Park, James, Kim, & Park, ] and increased amplitude of low‐frequency fluctuation in the right MTG [Li, Rossbach, Jiang, & Du, ] were identified in individuals with ASD.…”

Section: Introductionmentioning

confidence: 99%

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Specific Functional Connectivity Patterns of Middle Temporal Gyrus Subregions in Children and Adults with Autism Spectrum Disorder

Wang

et al. 2019

Autism Research

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As one of the key regions in the “social brain” network, the middle temporal gyrus (MTG) has been widely reported to be associated with autism spectrum disorder (ASD), but there have been contradictory results in terms of whether it shows hyperconnectivity or hypoconnectivity. Delineating roles of MTG at the subregional level may eliminate the observed inconsistencies and provide a new avenue to reveal the neurophysiologic mechanism of ASD. Thus, we first performed connectivity‐based parcellation using the BrainMap database to identify fine‐grained functional topography of the MTG. Then, the MTG subregions were used to investigate differences in the functional connectivity in children and adults with ASD using two data sets from Autism Brain Imaging Data Exchange database. Four distinct subregions in the human left and right MTG were identified, including the anterior MTG (aMTG), middle‐anterior MTG (maMTG), middle‐posterior MTG, and posterior MTG (pMTG). The bilateral pMTG was more vulnerable in both children and adults with ASD than in the typically developing (TD) group, mainly showing hypoconnectivity with different brain regions. In addition, the bilateral aMTG and right maMTG also showed altered functional connectivity in adults with ASD compared to the TD group. Moreover, all these altered MTG subregions were mainly associated with social cognition and language, as revealed by functional characterization. Further correlation analyses also showed trends of association between altered connectivity of the left aMTG and the Autism Diagnostic Observation Schedule scores in adults with ASD. Together, these results suggest a potential objective way to explore sub‐regional differences associated with such disorders. Autism Res 2020, 13: 410–422. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Four distinct subregions in the human left and right middle temporal gyrus (MTG) were identified, including the anterior MTG (aMTG), middle‐anterior MTG (maMTG), middle‐posterior MTG, and posterior MTG (pMTG). The bilateral pMTG was more vulnerable in both children and adults with autism spectrum disorder (ASD) than in the typically developing (TD) group, mainly showing hypoconnectivity with different brain regions. In addition, the bilateral aMTG and right maMTG also showed altered functional connectivity in adults with ASD compared to the TD group. Moreover, all these altered MTG subregions were mainly associated with social cognition and language, as revealed by functional characterization. Further correlation analyses also showed trends of association between altered connectivity of the left aMTG and the Autism Diagnostic Observation Schedule scores in adults with ASD.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Specific Functional Connectivity Patterns of Middle Temporal Gyrus Subregions in Children and Adults with Autism Spectrum Disorder

Wang

et al. 2019

Autism Research

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“…It is possible that bilateral middle temporal hypo-activation may be a general characteristic of language processing in ASD. This is noteworthy given the broad range of functions MTG plays in language processing, including auditory processing, semantic associations, and integration of words with meaning [Price, 2012].This is consistent with previous reports of MTG alterations in ASD, including decreased local connectivity [Itahashi et al, 2015] and altered morphology [Libero, DeRamus, Deshpande, & Kana, 2014]. However, MTG hypo-activation is seen in studies where task performance was intact, suggesting that the difference in language processing in ASD is not necessarily a weakness.…”

Section: Discussionsupporting

confidence: 83%

Hemispheric differences in language processing in autism spectrum disorders: A meta‐analysis of neuroimaging studies

et al. 2016

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Language impairments, a hallmark feature of autism spectrum disorders (ASD), have been related to neuroanatomical and functional abnormalities. Abnormal lateralization of the functional language network, increased reliance on visual processing areas, and increased posterior brain activation have all been reported in ASD and proposed as explanatory models of language difficulties. Nevertheless, inconsistent findings across studies have prevented a comprehensive characterization of the functional language network in ASD. The aim of this study was to quantify common and consistent patterns of brain activation during language processing in ASD and typically developing control (TD) participants using a meta-analytic approach. Activation likelihood estimation (ALE) meta-analysis was used to examine 22 previously published functional Magnetic Resonance Imaging (fMRI)/positron emission tomography studies of language processing (ASD: N = 328; TD: N = 324). Tasks included in this study addressed semantic processing, sentence comprehension, processing figurative language, and speech production. Within-group analysis showed largely overlapping patterns of language-related activation in ASD and TD groups. However, the ASD participants, relative to TD participants, showed: (1) more right hemisphere activity in core language areas (i.e., superior temporal gyrus and inferior frontal gyrus), particularly in tasks where they had poorer performance accuracy; (2) bilateral MTG hypo-activation across many different paradigms; and (3) increased activation of the left lingual gyrus in tasks where they had intact performance. These findings show that the hypotheses reviewed here address the neural and cognitive aspects of language difficulties in ASD across all tasks only in a limited way. Instead, our findings suggest the nuances of language and brain in ASD in terms of its context-dependency. Autism Res 2016, 9: 1046-1057. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

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“…However it remains unclear how these results relate to patterns of atypical local connectivity reported using fMRI (e.g. Itahashi et al, 2015;Keown et al, 2013), and conflicting results are often reported. For example, You et al, (2013) used fMRI to compare functional connectivity during resting state and sustained attention in ASD and control groups.…”

Section: Task-related and Task-free Global Oscillatory Connectivity Dmentioning

confidence: 82%

Brain oscillations and connectivity in autism spectrum disorders (ASD): new approaches to methodology, measurement and modelling

Kessler

Seymour

Rippon

2016

Neuroscience & Biobehavioral Reviews

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Please cite this article as: Kessler, K., Seymour, R.A., Rippon, G., Brain oscillations and connectivity in autism spectrum disorders (ASD): new approaches to methodology, measurement and modelling.Neuroscience and Biobehavioral Reviews http://dx.doi.org/10. 1016/j.neubiorev.2016.10.002 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Abstract:Although atypical social behaviour remains a key characterisation of ASD, the presence of sensory and perceptual abnormalities has been given a more central role in recent classification changes. An understanding of the origins of such aberrations could thus prove a fruitful focus for ASD research. Early neurocognitive models of ASD suggested that the study of high frequency activity in the brain as a measure of cortical connectivity might provide the key to understanding the neural correlates of sensory and perceptual deviations in ASD. As our review shows, the findings from subsequent research have been inconsistent, with a lack of agreement about the nature of any high frequency disturbances in ASD brains.Based on the application of new techniques using more sophisticated measures of brain synchronisation, direction of information flow, and invoking the coupling between high and low frequency bands, we propose a framework which could reconcile apparently conflicting findings in this area and would be consistent both with emerging neurocognitive models of autism and with the heterogeneity of the condition.

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Alterations of local spontaneous brain activity and connectivity in adults with high-functioning autism spectrum disorder

Cited by 84 publications

References 93 publications

Specific Functional Connectivity Patterns of Middle Temporal Gyrus Subregions in Children and Adults with Autism Spectrum Disorder

Specific Functional Connectivity Patterns of Middle Temporal Gyrus Subregions in Children and Adults with Autism Spectrum Disorder

Hemispheric differences in language processing in autism spectrum disorders: A meta‐analysis of neuroimaging studies

Brain oscillations and connectivity in autism spectrum disorders (ASD): new approaches to methodology, measurement and modelling

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