Alterations of intestinal microbiota in liver cirrhosis with muscle wasting

Ren, Xiaojing; Hao, Shasha; Yang, Cangjie; Yuan, Lili; Zhou, Xiaoshuang; Zhao, Hongguang; Yao, Jia

doi:10.1016/j.nut.2020.111081

Cited by 18 publications

(22 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These patients also had increased abundance of Eggerthella , which is considered a biomarker of fragility[ 29 , 30 ]. These findings are consistent with recent studies of the gut microbiome in cirrhosis patients with sarcopenia[ 4 , 5 ]. However, body cell mass deficiency in cirrhosis patients was found to be associated with a decrease in the abundance of Coprococcus , Intestinimonas , Catenibacterium , and Barnesiellaceae in our study, which was not reported in these earlier studies[ 4 , 5 ].…”

Section: Discussionsupporting

confidence: 93%

“…These findings are consistent with recent studies of the gut microbiome in cirrhosis patients with sarcopenia[ 4 , 5 ]. However, body cell mass deficiency in cirrhosis patients was found to be associated with a decrease in the abundance of Coprococcus , Intestinimonas , Catenibacterium , and Barnesiellaceae in our study, which was not reported in these earlier studies[ 4 , 5 ]. A decrease in the abundance of the butyrate-producing Coprococcus has been reported in hemodialysis patients with sarcopenia[ 31 ].…”

Section: Discussionsupporting

confidence: 93%

“…Catenibacterium is associated with the development of insulin resistance in morbid obesity[ 35 ]; thus, it is quite possible that a decrease in its content in the gut microbiome is associated with malnutrition. Decreased abundance of Barnesiellaceae and increased abundance of Veillonella in the gut microbiome, found in our study in patients with body cell mass deficiency, have previously been described in the general cohort of sarcopenic patients[ 36 ], but not in earlier investigations of sarcopenia in cirrhosis patients[ 4 , 5 ].…”

Section: Discussionsupporting

confidence: 60%

“…Although recent publications have reported the associations of some taxa of the gut microbiome with sarcopenia diagnosed by computed tomography[ 4 , 5 ], no studies have investigated the relations between the gut microbiome and all three main body components (fat, cells, and extracellular fluid) in cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Gut dysbiosis and body composition in cirrhosis

Maslennikov¹,

Ивашкин²,

Alieva³

et al. 2022

WJH

View full text Add to dashboard Cite

BACKGROUND Gut dysbiosis and changes in body composition ( i.e. , a decrease in the proportion of muscle mass and an increase in extracellular fluid) are common in cirrhosis. AIM To study the relationship between the gut microbiota and body composition in cirrhosis. METHODS This observational study included 46 patients with cirrhosis. Stool microbiome was assessed using 16S rRNA gene sequencing. Multifrequency bioelectrical impedance analysis was performed to assess body composition in these patients. RESULTS An increase in fat mass and a decrease in body cell mass were noted in 23/46 (50.0%) and 15/46 (32.6%) patients, respectively. Changes in the gut microbiome were not independently associated with the fat mass percentage in cirrhosis. The abundance of Bacteroidaceae ( P = 0.041) and Eggerthella ( P = 0.001) increased, whereas that of Erysipelatoclostridiaceae ( P = 0.006), Catenibacterium ( P = 0.021), Coprococcus ( P = 0.033), Desulfovibrio ( P = 0.043), Intestinimonas ( P = 0.028), and Senegalimassilia ( P = 0.015) decreased in the gut microbiome of patients with body cell mass deficiency. The amount of extracellular fluid increased in 22/46 (47.6%) patients. Proteobacteria abundance ( P < 0.001) increased, whereas Firmicutes ( P = 0.023), Actinobacteria ( P = 0.026), Bacilli ( P = 0.008), Anaerovoraceceae ( P = 0.027), Christensenellaceae ( P = 0.038), Eggerthellaceae ( P = 0.047), Erysipelatoclostridiaceae ( P = 0.015), Erysipelotrichaceae ( P = 0.003), Oscillospiraceae ( P = 0.024), Rikenellaceae ( P = 0.002), Collinsella ( P = 0.030), Hungatella ( P = 0.040), Peptococcaceae ( P = 0.023), Slackia ( P = 0.008), and Senegalimassilia ( P = 0.024) abundance decreased in these patients. Patients with clinically sig...

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gut dysbiosis and body composition in cirrhosis

Maslennikov¹,

Ивашкин²,

Alieva³

et al. 2022

WJH

View full text Add to dashboard Cite

show abstract

“… [3] , [4] , [5] , [6] However, most studies focused only on muscle mass but ignored muscle strength and performance, which are determinant factors of sarcopenia. [4] , [5] , [6] , [7] Given that sarcopenia has important impacts on cirrhotic outcomes, identification of risk factors that could be therapeutically modulated may have significant clinical significance in cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

Sarcopenia-related gut microbial changes are associated with the risk of complications in people with cirrhosis

Lee

Lee²,

Yang³

et al. 2023

JHEP Reports

View full text Add to dashboard Cite

Analysis of intestinal flora in elderly Uygur patients with sarcopenia

Shan,

Cheng,

Zhu

et al. 2024

Immunity Inflam & Disease

View full text Add to dashboard Cite

ObjectiveThis study was designed to analyze the structural characteristics of the intestinal flora of elderly Uygur patients with sarcopenia, thereby providing new ideas for clinical treatment.MethodsFirstly, fecal samples were collected from 40 elderly Uygur patients with sarcopenia (Sarcopenia group) and 40 healthy people (Control group). Next, significant differences in the intestinal flora between the two groups were analyzed based on 16S rDNA high‐throughput sequencing. The linear discriminant analysis effect size (LEfSe) was used to estimate the magnitude of the effect of each component (species) abundance on the differential effect. Additionally, an analysis was also performed on the relationship between the intestinal flora and the cytokines in the peripheral blood of patients with sarcopenia.ResultsThe results of β diversity showed that there were differences in the structure of the intestinal flora between the two groups. Besides, the phylum level of intestinal flora between the two groups was not significantly different. However, the difference was significant in the intestinal flora at the order, family, and genus levels between the two groups. Among them, Lachnoclostridium, Photobacterium, Anaerobic Bacillus, Hydrogenophilus, and Eubacterium were enriched in the Sarcopenia group; Prevotella 9, Firmicutes FCS020 group, Streptobacillus, Aggregatibacter, Corynebacterium, Clostridium Difficile, and Haloanaerobium were enriched in the Control group. The LEfSe outcomes further showed that Lachnoclostridium was highly enriched in the Sarcopenia group; Prevotella 9 and Firmicutes FCS020 group were significantly enriched in the Control group. Furthermore, the relative abundance of Lachnoclostridium and Streptobacillus were significantly different in patients with high and low IL‐6 levels.ConclusionIn conclusion, Lachnoclostridium is significantly enriched in the intestines of elderly Uygur patients with sarcopenia; the increase in Lachnoclostridium abundance and the decrease in Streptobacillus abundance are associated with high levels of IL‐6. Therefore, abnormal intestinal flora is related to inflammatory reflexes in patients with sarcopenia.

show abstract

Alterations of intestinal microbiota in liver cirrhosis with muscle wasting

Cited by 18 publications

References 29 publications

Gut dysbiosis and body composition in cirrhosis

Gut dysbiosis and body composition in cirrhosis

Sarcopenia-related gut microbial changes are associated with the risk of complications in people with cirrhosis

Analysis of intestinal flora in elderly Uygur patients with sarcopenia

Contact Info

Product

Resources

About