Alterations of heart rate variability in women with overactive bladder syndrome

Ben-Dror, Inbal; Weissman, Amir; Leurer, Michal Katz; Eldor-Itskovitz, Joseph; Löwenstein, Lior

doi:10.1007/s00192-012-1738-7

Cited by 19 publications

(18 citation statements)

References 24 publications

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“…Ben-Dror et al (2012) subsequently delineated a linear rise in lnLF power with acute bladder filling in healthy controls drinking water. While this may have been confounded with the osmopressor effect (as above), a similar effect was observed using filling cystometry (i.e., causing bladder distension without drinking; Mehnert et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Everything Hertz: methodological issues in short-term frequency-domain HRV

2014

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Frequency analysis of the electrocardiographic RR interval is a common method of quantifying autonomic outflow by measuring the beat-to-beat modulation of the heart (heart rate variability; HRV). This review identifies a series of problems with the methods of doing so-the interpretation of low-frequency spectral power, the multiple use of equivalent normalized low frequency (LFnu), high frequency (HFnu) and ratio (LF/HF) terms, and the lack of control over extraneous variables, and reviews research in the calendar year 2012 to determine their prevalence and severity. Results support the mathematical equivalency of ratio units across studies, a reliance on those variables to explain autonomic outflow, and insufficient control of critical experimental variables. Research measurement of HRV has a substantial need for general methodological improvement.Keywords: heart rate variability, autonomic nervous system, sympatho-vagal balance, sympathetic nervous system, parasympathetic nervous system INTRODUCTIONHeart rate variability (HRV), the fluctuation of instantaneous heart period over time, is a correlate of cardiac autonomic regulation. HRV techniques have been applied in a broad range of contexts-they have been used to predict mortality after myocardial infarction (Buccelletti et al., 2009), as a correlate of stress (Berntson and Cacioppo, 2007) and psychopathology, to stratify attention (Mulder and Mulder, 1981), and have been incorporated into biobehavioral models of self-regulation (Porges, 1995;Thayer and Lane, 2000). The idea that reliable measurement of autonomic state may be obtained cheaply and non-invasively is obviously appealing. Figure 1 illustrates a growing interest in HRV methods over time, a trend which seem likely to continue given the increasing access to heart rate data through recent technological advances-heart rate has recently been accurately calculated via smartphone (Heathers, 2013), microwave (Suzuki et al., 2008) and induction-powered indwelling device (Riistama et al., 2007). Short recordings of HRV (i.e., less than 1 h) typically show two primary patterns of oscillation which are separated into frequency bands from ≈7 to 25 s (0.04-0.15 Hz; low frequency, or LF) and 2.5 to ≈7 s (0.15-0.4 Hz; high frequency, or HF)-lower frequencies than LF are generally not meaningful over the short term. LF and HF frequency bands are widely used to quantify parasympathetic and sympathetic regulation (Akselrod et al., 1981) and their interaction (Malliani et al., 1991).As ease of access to HRV increases, establishing and maintaining correct methodology is important-redundant methodology may delay treatment, obscure valuable underlying effects, provoke Type I or II errors, and most importantly, potentially delegitimize both alternative useful results and the utility of HRV in general.However, the internal and external consistency of the methods used have received comparatively less research interest than the understanding of the autonomic, cardiac and circulatory which creates those methods (Billman, 201...

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Section: Introductionmentioning

confidence: 99%

Everything Hertz: methodological issues in short-term frequency-domain HRV

2014

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“…This divergence may have happened because the authors did not standardize the bladder filling. In another investigation 14 the ANS function was compared among 9 women with OAB and 15, without OAB, during bladder filling. ECG signals were used to evaluate HRV.…”

Section: Discussionmentioning

confidence: 99%

“…In a few studies 7,14,18 an increase in sympathetic ANS was observed during bladder filling sensations in the control groups, since the authors defended the theory that a continuous increase in sympathetic activity was required during bladder filling, to allow the bladder to expand without contraction of the detrusor. However, in this study there was a decline in sympathetic activation, with a significant difference (p<0.02) between LogLF and LogHF for FUU, SUU and MBC.…”

Section: Discussionmentioning

confidence: 99%

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Avaliação da modulação autonômica cardíaca no processo de enchimento da bexiga em mulheres com incontinência urinária: perspectiva da fisioterapia

et al. 2017

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RESUMO Comparou-se o comportamento do sistema nervoso autônomo, por meio da variabilidade da frequência cardíaca (VFC), durante as fases de enchimento vesical de mulheres com e sem incontinência urinária (IU). Aplicou-se o International Consultation on Incontinence Questionnaire - Short Form, para autodiagnóstico de IU. Para análise da VFC utilizaram-se registros de eletrocardiograma (ECG), sendo 6 registros durante o enchimento vesical. Para quantificar a VFC utilizaram-se os métodos: domínio do tempo (milissegundos); frequência (Hertz) e medidas não lineares. A estes parâmetros aplicou-se transformação logarítmica (Log). Na comparação de médias de dados normais utilizou-se teste t e para os dados não normais o teste de Mann-Whitney. Participaram 64 mulheres (64,8±6,73 anos), 33 com IU e 31 continentes. A variável logaritmo da razão dos componentes LF e HF (LogLH/HF) foi significativamente maior (p<0,05) no grupo continente em todos os momentos do enchimento vesical. A capacidade volumétrica vesical foi significativamente maior nas mulheres continentes (p=0,0015). A análise no domínio da frequência demonstrou redução da função simpática e aumento do parassimpático nas mulheres incontinentes. As mulheres continentes apresentaram melhor balanço autonômico durante todo processo de enchimento vesical, em comparação às incontinentes. A redução da função simpática, bem como o aumento da função parassimpática nas incontinentes, pôde ser reportada para uma diminuição da capacidade de relaxamento do detrusor e um aumento das contrações, ainda na fase de enchimento vesical, ambos associados à IU.

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“…Moreover, it is widely known that the autonomic nervous system (ANS) is involved in the regulation of the micturition cycle. That is, there are several reports about the correlation between the activity of the ANS and the LUTS [3,4,5,6]. It is presumed that the central sympathetic overactivity might be associated with the LUTS in patients with benign prostatic hyperplasia (BPH); it is associated with metabolic syndrome in men [1,7].…”

Section: Introductionmentioning

confidence: 99%

The Correlation Between the Treatment Efficacy and the Sympathetic Activity in Men With Lower Urinary Tract Symptoms

et al. 2014

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PurposeIn this study, we examined the difference in the treatment efficacy depending on the sympathetic activity in men with lower urinary tract symptoms (LUTS).MethodsIn the current single-center, retrospective study, we evaluated a total of 66 male patients aged 40-70 years of age, presenting with LUTS, whose International Prostate Symptom Score (IPSS) exceeded 8 points. They had a past 3-month history of taking alfuzosin XL, and their heart rate variability (HRV) was measured before and after the treatment. In addition, we also recruited 39 healthy volunteers who visited a health promotion center for a regular medical check-up. They were aged between 40 and 70 years and had an IPSS of <8 points. We divided the patients with LUTS into two groups: the groups A and B, based on a low frequency/high frequency (LF/HF) ratio of 1.7, which was the mean value of the LF/HF ratio in the healthy volunteers. After a 3-month treatment with alfuzosin XL, we compared treatment outcomes, based on the IPSS and peak urine flow rate, between the two groups.ResultsA 3-month treatment with alfuzosin XL, comprising the measurement of the HRV, was performed for the 23 patients of the group A (23/38) and 17 of the group B (17/28). After a 3-month treatment with alfuzosin XL, total IPSS and IPSS questionnaire 2 and 5 were significantly lower in the group A as compared with the group B. But this was not seen in the group B. Furthermore, there were no significant differences in other parameters, such as maximal flow rate and IPSS storage subscore, between the two groups.ConclusionsOur results indicate that the treatment efficacy was lower in patients with sympathetic hyperactivity as compared with those with sympathetic hypoactivity. Thus, our results will provide a basis for further studies to clarify causes of LUTS in a clinical setting.

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Alterations of heart rate variability in women with overactive bladder syndrome

Cited by 19 publications

References 24 publications

Everything Hertz: methodological issues in short-term frequency-domain HRV

Everything Hertz: methodological issues in short-term frequency-domain HRV

Avaliação da modulação autonômica cardíaca no processo de enchimento da bexiga em mulheres com incontinência urinária: perspectiva da fisioterapia

The Correlation Between the Treatment Efficacy and the Sympathetic Activity in Men With Lower Urinary Tract Symptoms

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