Alterations of gut microbiota in gestational diabetes patients during the second trimester of pregnancy in the Shanghai Han population

Su, Yao; Wang, Hongkun; Gan, Xu-Pei; Chen, Li; Cao, Yannan; Cheng, De-Cui; Zhang, Dong-Yao; Yu, Wen; Li, Feifei; Xu, Xiao

doi:10.1186/s12967-021-03040-9

Cited by 17 publications

(20 citation statements)

References 50 publications

(58 reference statements)

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“…In line with the study of Ma et al [ 22 ], the current results revealed that Ruminococcaceae were more abundant in the NGT group than in the GDM group. However, other studies have observed the opposite result[ 23 , 24 ]. The mechanisms remain unclear.…”

Section: Discussionmentioning

confidence: 90%

Correlation between gut microbiota and glucagon-like peptide-1 in patients with gestational diabetes mellitus

Liang¹,

Liu²,

Jia³

et al. 2022

World J Diabetes

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BACKGROUND Gestational diabetes mellitus (GDM) places both the mother and offspring at high risk of complications. Increasing evidence suggests that the gut microbiota plays a role in the pathogenesis of GDM. However, it is still unclear whether the gut microbiota is related to blood biochemical traits, particularly glucagon-like peptide-1 (GLP-1), in GDM patients. AIM To explore the correlation between the gut microbiota and blood biochemical traits, particularly GLP-1, in GDM patients. METHODS The V4 region of the 16S ribosomal ribonucleic acid (rRNA) gene was sequenced based on the fecal samples of 35 pregnant women with GDM and was compared to that of 25 pregnant women with normal glucose tolerance (NGT). RESULTS The results showed that Ruminococcaceae_UCG-002 , Ruminococcaceae_UCG-005 , Clostri-dium_sensu_stricto_1 , and Streptococcus were more abundant in the NGT group than in the GDM group . Bacteroides and Lachnoclostridium were more abundant in the GDM group than in the NGT group. Spearman’s correlation analysis was performed to identify the relationships between microbiota genera and blood biochemical traits. Paraprevotella , Roseburia , Faecalibacterium , and Ruminococcaceae_UCG-002 were significantly negatively correlated with glucose. Ruminococcaceae_UCG-002 was significantly negatively correlated with hemoglobin A1c. Bacteroides was significantly positively correlated with glucose. Sutterella , Oscillibacter , and Bifidobacterium were significantly positively correlated with GLP-1. A random forest model showed that 20 specific genera plus glucose provided the best discriminatory power, as indicated by the area under the receiver operating characteristic curve (0.94). CONCLUSION The results of this study reveal novel relationships between the gut microbiome, blood bio-chemical traits, particularly GLP-1, and GDM status. These findings suggest that some genera are crucial for controlling blood glucose-related indices and may be beneficial for GDM treatment. Alteration in the microbial composition of the gut may potentially serve as a marker for identifying individuals at risk of GDM.

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Section: Discussionmentioning

confidence: 90%

Correlation between gut microbiota and glucagon-like peptide-1 in patients with gestational diabetes mellitus

Liang¹,

Liu²,

Jia³

et al. 2022

World J Diabetes

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“…Actinobacteria phylum was increased according to Hou et al. ( 51 ), but its expression was otherwise decreased in few other studies ( 29 , 52 , 53 ). Verrucomicrobia was mostly increased ( 51 , 54 ), and Fusobacteria was increased in Hou et al.’s study ( 51 ).…”

Section: Resultsmentioning

confidence: 85%

“…The studies that were assessed as high-quality studies are highlighted. All the 22 cohort studies had a good quality according to our assessment ( 17 – 20 , 23 – 25 , 27 , 29 – 32 , 35 , 40 , 44 , 47 , 48 , 53 – 55 , 59 , 63 ). One cohort study did not meet the NOS criteria and was labeled as unsatisfactory ( 16 ).…”

Section: Resultsmentioning

confidence: 90%

“…This inconsistency was also seen in the phylum Bacteroidetes, as it was increased in most of the studies ( 23 , 46 , 51 – 53 ), while it was not different among the compared groups in two studies ( 28 , 35 ) and it was decreased in one study ( 29 ). The phylum Proteobacteria showed a variable change in its frequency in the gut microbiome of the pregnant women with GDM ( 51 ).…”

Section: Resultsmentioning

confidence: 92%

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Microbiome alterations in women with gestational diabetes mellitus and their offspring: A systematic review

et al. 2022

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AimsGestational diabetes mellitus (GDM) is a metabolic disorder that might predispose pregnant women to develop type 2 Diabetes Mellitus or lead to severe adverse outcomes in their offspring. One of the factors that have been thought to be involved in the pathology behind this disorder is the microbiome. In this systematic review, we comprehensively review the documents regarding the microbiota alterations in different tracts of pregnant women with GDM and their offspring.MethodsA comprehensive search was conducted in major databases including MEDLINE (PubMed), Scopus, and Web of sciences up to August 2021. Data on the demographics, methodology, and microbiome alterations were extracted and classified according to the type of microbiome in pregnant women with GDM and their offspring. The quality of studies was assessed using the Newcastle-Ottawa Scale (NOS).ResultsIn 49 articles which were retrieved, the findings were variable on the level of changes in alpha and beta diversity, enrichment or depletion in phyla, genera, species and OTUs, in each microbiome type. Although there were some inconsistencies among the results, a pattern of significant alterations was seen in the gut, oral, vaginal microbiome of women with GDM and gut, oral, and placental microbiome of their offspring.ConclusionEven though the alteration of the microbiome of the different tracts was seen in the cases of GDM, the inconsistency among the studies prevents us from identifying unique pattern. However, the results seem promising and further studies that overcome the confounding factors related to the demographics and methodology are needed.

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“…Environmental factors, such as maternal obesity, diet, and physical activity; pregnancy-related factors, such as excessive fat storage and increased secretion of adipokine and cytokines (e.g., tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6)) [ 5 ]; and genetics also contribute to the development of IR in pregnancy [ 3 ]. A large amount of scientific data from the last two decades has also indicated the role of gut microbiota in the development of gestational glucose intolerance during pregnancy [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Probiotics in the Prevention and Treatment of Gestational Diabetes Mellitus (GDM): A Review

et al. 2022

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Gestational diabetes mellitus (GDM)is one of the most common perinatal pathologies, with a prevalence of 5–20% depending on the population or diagnostic standards. It is diagnosed when glucose intolerance is first detected during pregnancy. In the pathogenesis of GDM, genetic, environmental, and pregnancy-related factors (excessive fat storage and increased adipokine and cytokine secretion) play important roles. A growing amount of scientific data has indicated the role of gut microbiota (GM) dysbiosis in the development of glucose intolerance during pregnancy. Previous studies have indicated that, in comparison to healthy pregnant women, GDM individuals have a greater abundance of bacteria belonging to the genera Ruminococcus, Eubacterium, and Prevotella and a lower number of bacteria belonging to the genera Bacteroides, Parabacteroides, Roseburia, Dialister, and Akkermansia. Recently, many studies have focused on treating GDM with methods targeting GM. Several previous studies have analyzed the effect of probiotics on the course of GDM, but their data are inconclusive. In view of this state, the aim of the study was to collect and comprehensively discuss current knowledge regarding the role of probiotic supplementation in preventing and treating GDM. According to the analyzed data, probiotics have a positive influence on glycemic control and are a promising tool for lowering the frequency of GDM. However, further studies must be conducted to determine the optimal model of probiotic therapy (strain, dose, time of intervention, etc.) in pregnant women with GDM.

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Alterations of gut microbiota in gestational diabetes patients during the second trimester of pregnancy in the Shanghai Han population

Cited by 17 publications

References 50 publications

Correlation between gut microbiota and glucagon-like peptide-1 in patients with gestational diabetes mellitus

Correlation between gut microbiota and glucagon-like peptide-1 in patients with gestational diabetes mellitus

Microbiome alterations in women with gestational diabetes mellitus and their offspring: A systematic review

Probiotics in the Prevention and Treatment of Gestational Diabetes Mellitus (GDM): A Review

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