Alterations of gut barrier and gut microbiota in food restriction, food deprivation and protein-energy wasting

Genton, Laurence; Cani, Patrice D.; Schrenzel, Jacques

doi:10.1016/j.clnu.2014.10.003

Cited by 107 publications

(66 citation statements)

References 105 publications

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“…PAMPs bind toll-like receptors that induce proinflammatory responses which might result in a condition termed 'metabolic endotoxemia' [67]. Metabolic endotoxemia is featured by a chronic low-grade inflammatory state and is often associated with obesity and insulin resistance [67,68]. Butyrate is thought to enhance the intestinal barrier function by facilitating tight junctions, which is theorized to reduce the uptake of PAMPs [4,69].…”

Section: Immunity and Inflammationmentioning

confidence: 99%

The intestinal microbiota, energy balance, and malnutrition: emphasis on the role of short-chain fatty acids

Fluitman

Clercq

Keijser

et al. 2017

Expert Review of Endocrinology & Metabolism

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Introduction: Malnutrition refers to both over-and undernutrition and results from a disruption in energy balance. It affects one in three people worldwide and is associated with increased morbidity and mortality. The intestinal microbiota represents a newly identified factor that might contribute to the development of malnutrition, as it harbors traits that complement the human metabolic and endocrine capabilities, thereby influencing energy balance. Areas covered: In the current review, we aim to give a comprehensive overview on the microbiota, its development and its possible influence on energy balance, with emphasis the role of short-chain fatty acids. We also consider microbial characteristics associated with obesity and undernutrition and evaluate microbial manipulating strategies. The PubMed database was searched using the terms:

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Section: Immunity and Inflammationmentioning

confidence: 99%

The intestinal microbiota, energy balance, and malnutrition: emphasis on the role of short-chain fatty acids

Fluitman

Clercq

Keijser

et al. 2017

Expert Review of Endocrinology & Metabolism

View full text Add to dashboard Cite

show abstract

“…These different daily diet types may alter the enteric microbiota population, affecting herbal compound gut metabolism and absorption (Moco et al , 2012; Genton et al , 2015; Janssen et al , 2015; Simpson and Campbell, 2015). Thus, significant level differences of Rb 1 and compound K in biological samples observed in our study can be contributed to the consumption of two different types of diet and subsequently induced enteric microbiota profile change.…”

Section: Resultsmentioning

confidence: 99%

Significant difference in active metabolite levels of ginseng in humans consuming Asian or Western diet: The link with enteric microbiota

Wan

Wang

Zhang

et al. 2016

Biomedical Chromatography

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After ginseng ingestion, the bioavailability of its parent compounds is low and enteric microbiota plays an important role in parent compound biotransformation to their metabolites. Diet type can influence the enteric microbiota profile. When human subjects on different diets ingest ginseng, their gut microbiota's different profile may influence the metabolism of ginseng parent compounds. In this study, the effects of different diet type on gut microbiota metabolism of American ginseng saponins were investigated. We recruited six healthy adults who regularly consume different diet type. These subjects received 7 days oral American ginseng, and their biological samples were collected for LC-Q-TOF-MS analysis. We observed significant ginsenoside Rb1 (a major parent compound) and compound K (a major active metabolite) level differences in the samples from the subjects consuming different diet. Subjects on Asian diet have much higher Rb1 levels but much lower compound K levels compared to those on Western diet. Since compound K possesses much better cancer chemoprevention potential, our data suggested that consumers on Western diet should obtain better cancer prevention effects with American ginseng intake compared to those on Asian diet. Ginseng compound levels could be enhanced or reduced via gut microbiota manipulation for clinical utility.

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“…Genton et al, reviewed the present knowledge regarding the in vivo impact of depleted nutritional states on structure and function of the GM in addition to the gut epithelium, the gut-associated lymphoid tissue, and the enteric nervous system. Their article revealed the complexity of the interactions between the components of gut barrier in depleted states due to food restriction and protein energy wasting and shows that these interactions are multi-directional nature to suggest the existence of feedbacks pathway [12] . One of the interesting aspect of GM is that its status in obese subjects is different from that of lean subjects, implying the possibility of its involvement in the maintenance of the body metabolism such as energy utilization and fat metabolism.…”

Section: Aloe Vera Gel On Immune Modulationmentioning

confidence: 99%

Gut Microbiota: Influence of Aloe vera gel and Calorie Restriction

Yagi

2017

Journal of Gastroenterology and Hepatology Research

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The health-promoting potential of a balanced gut microbiota status modulated by calorie restriction (CR) posits a possible close link between gut microbiota (GM) and healthy aging. Short chain fatty acids (SCFAs) generated from intestinal bacterial fermentation may act as mediators between the microbiota and the immune system. In this review, a putative prophylactic role of butyric acid from endophytic bacteria fermentation of Aloe vera gel was described to suggest that the consumption of fermented extract of Aloe vera gel may be beneficial for health and QOL as an immune modulator.

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Alterations of gut barrier and gut microbiota in food restriction, food deprivation and protein-energy wasting

Cited by 107 publications

References 105 publications

The intestinal microbiota, energy balance, and malnutrition: emphasis on the role of short-chain fatty acids

The intestinal microbiota, energy balance, and malnutrition: emphasis on the role of short-chain fatty acids

Significant difference in active metabolite levels of ginseng in humans consuming Asian or Western diet: The link with enteric microbiota

Gut Microbiota: Influence of Aloe vera gel and Calorie Restriction

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