Alterations of erythrocyte antioxidant mechanisms: Antioxidant enzymes, lipid peroxidation and serum trace elements associated with anemia in bovine tropical theileriosis

Razavi, S. M.; Nazifi, Saeed; Bateni, Masoumeh Heidari; Rakhshandehroo, Ehsan

doi:10.1016/j.vetpar.2011.03.011

Cited by 38 publications

(21 citation statements)

References 23 publications

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“…Parasitol., 10 (4): 151-159, 2015 stress through autoxidation of Hcy yielding hydrogen peroxide (Loscalzo, 1996). Thus, the elevation of Hcy in parasitized cattle in our study can also corroborate the results of preceding studies that implicate the role of oxidative stress on damaging erythrocytes and the anemia Razavi et al, 2011), as well as emphasize the probable formation of endothelial injuries and coagulation disorders (like disseminated intravascular coagulation) due to occurred hyperhomocysteinemia, which, in turn, could help the appearance of anemia.…”

Section: Discussionsupporting

confidence: 90%

“…Although this finding has been discussed in the cases of bovine (Shiono et al, 2003;Razavi et al, 2011) and ovine theileriosis , the underlying mechanisms of such a progressive anemia are still not clearly understood. However, low levels of RBCs, PCV and hemoglobin concentration in bovine theileriosis due to T. annulata have been attributed to erythrocytes destruction by macrophages in the lymph nodes, spleen and other organs of the monocyte-macrophage system (Singh et al, 2001) and also one recent hypothesis indicates the interference of the parasite with protective antioxidant mechanisms of RBCs against oxidative damages (Shiono et al, 2003;Razavi et al, 2011).…”

Section: Discussionmentioning

confidence: 95%

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Bovine Theileriosis: Effects on the Status of Thyroid Hormones, Homocystein, Serum Lipids and Lipoproteins

Razavi¹,

Moghaddas²,

Rakhshande³

et al. 2015

Research J. of Parasitology

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Tropical theileriosis of cattle is a common tick-borne disease in tropical and subtropical regions and is recognized as a disease of major economic importance. This study aimed to determine whether Theileria annulata infection influences the plasma homocystein (Hcy), thyroid activity and serum lipid status in infected cattle. Fifty crossbred Holstein cattle, naturally infected with Theileria annulata were selected and divided into 3 subgroups according to their parasitemia rates (<2, 2-4, 4-8%). Also, 10 non-infected cattle were assigned as controls. Blood samples were collected and hematological parameters, plasma Homocystein (Hcy), thyroid hormones (T 3 , T 4 , free T3 (fT 3 ) and free T 4 (fT 4 )) and the concentrations of serum lipid and lipoproteins (cholesterol, triglyceride and lipoproteins including HDL, LDL and VLDL cholesterol) and phosphatidylserine (PS) on erythrocytes were measured. According to the results, significant elevations were observed in the concentration of plasma Hcy (hyperhomocysteinemia) in the infected groups compared to controls. In addition, we conclude that T. annulata can interfere with the lipid metabolism, which is particularly characterized by substantial decreases in the levels of cholesterol, LDL and HDL in the serum of affected animals. In spite of remarkable influences of the parasite on Hcy and lipid contents of the serum, our study proved that tropical theileriosis did not affect the thyroid hormones during parasitemia. This study demonstrates that the infection of cattle with Theileria annulata is mainly characterized by the anemia. Also, evidenced elevation in the level of homocystein (hyperhomocysteinemia) in parasitized cattle can result in oxidative stress on erythrocytes and the probable endothelial injuries. In addition, T. annulata can induce failure in lipid metabolism which is particularly featured by a decrease in the cholesterol, LDL-cholesterol and HDL-cholesterol concentrations; however the parasite cannot implement significant influences on the thyroid hormones in the affected cattle.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 95%

Bovine Theileriosis: Effects on the Status of Thyroid Hormones, Homocystein, Serum Lipids and Lipoproteins

Razavi¹,

Moghaddas²,

Rakhshande³

et al. 2015

Research J. of Parasitology

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“…This finding is in line with the cases discussed in bovine (Shiono et al, 2003;Razavi et al, 2011) and ovine theileriosis , however, the underlying mechanisms of anemia are still a matter of debate. Low levels of RBCs, PCV and hemoglobin concentration in bovine theileriosis due to T. annulata have been attributed to erythrocytes destruction by macrophages in the lymph nodes, spleen and other organs of the monocyte-macrophage system (Singh et al, 2001).…”

Section: Discussionsupporting

confidence: 89%

Correlations Among the Level of Homocysteine, Antioxidant Enzymes, Antioxidant Vitamins and Lipid Peroxidation of Erythrocytes in Malignant Ovine Theileriosis

Razavi¹,

Nazifi²,

Mokhtari³

et al. 2015

Research J. of Parasitology

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Malignant ovine theileriosis is a fatal disease of sheep caused by Theileria hirci. The present study was designed to estimate the levels of plasma Homocysteine (Hcy), antioxidant enzymes, antioxidant vitamins and lipid peroxidation of erythrocytes and also to evaluate their correlations in different parasitemia rates in naturally infected sheep. Fifty Iranian sheep, about 1-2 years old, naturally infected with T. hirci were selected and divided into 2 subgroups according to their parasitemia rates (<2%, 2-4%). Ten non-infected animals were also selected as controls. Blood samples were collected and Hcy, antioxidant enzymes, antioxidant vitamins and lipid peroxidation of erythrocytes were measured. Our results showed that the activities of erythrocytic antioxidant enzymes including SOD, GPX and catalase were substantially reduced in infected sheep. Furthermore, the animals with higher parasitemia rate showed remarkable declines in SOD, GPX and catalase activities. There was a significant rise in the level of MDA, particularly in the animals with the higher (2-4%) parasitemia rates. In addition, it was evident that coinciding with the elevation of the parasite-bearing erythrocytes in infected animals, the level of lipid peroxidation in RBC membrane was significantly increased. Although the concentration of vitamin C showed a significant decrease in infected sheep with <2% parasitemia rate, the concentrations of antioxidant vitamins (A and E) generally showed no remarkable alterations. In our study, a significant increase was evident in the level of homocysteine in sheep suffering from theileriosis. Our data also showed that the increase in of parasitemia was coupled with the elevation of homocysteine level (r = 0.34, p<0.05).

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“…These results were confirmed by Priscila and Heather (2000) and Jens and Ove et al, (2006). A significant decrease of glutathione peroxidase of respiratory manifested calves was supported by AlQudah (2009);Razavi (2011) andPour (2013) who stated that GSH-Px activity is a major mechanism for intracellular decomposition of lipid peroxides and has a crucial role in membranes protection from them, particularly airspace epithelium of lung Cantin et al, (1989). Therefore (GSH-Px) would limit production of radical oxygen species at the beginning of the bronchopneumonia (acute form) until cellular amounts of the reduced glutathione would become insufficient for hydroperoxide reduction by GSH-Px.…”

Section: Discussionmentioning

confidence: 85%

Clinical and Haematobiochemical Evaluation of Pneumonia in Calves with Special Reference to Oxidant/Antioxidant Indices

Ismael¹,

El-Sayed²,

Metwally³

et al. 2017

AJVS

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Key words:Oxidative stress, antioxidants, pneumonia in calves.Pneumonia and pneumoenteritis are the major problems affect health and performance of calves and induce many losses even with treatment. Thirty calves were subjected to study; fifteen calves (group 1) showed fever, cough, bilateral mucopurulent nasal discharges with abnormal lung sound on auscultation. The remained fifteen calves were apparently clinically healthy and kept as control group (group 2). Clinical observation had been done and complete blood picture, oxidant/antioxidant profile and serum sodium, potassium and chloride were evaluated. Results of hematological analysis of group 1 showed a significant reduction in the RBCs count, Hb content, PCV and MCV indicating microcytic hypochromic anemia associated with a non-significant increase in the MCH and significant increase in both of MCHC and WBCs indicating leukocytosis. Results of oxidant/antioxidant profile of group 1 showed a significant reduction in the activity of CAT, SOD, GSH, GSH-Px and TAC values associated with a significant increase in the MDA level. While levels of serum electrolytes of group 1 showed a significant reduction in Na and Cl with a significant increase in K.

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Alterations of erythrocyte antioxidant mechanisms: Antioxidant enzymes, lipid peroxidation and serum trace elements associated with anemia in bovine tropical theileriosis

Cited by 38 publications

References 23 publications

Bovine Theileriosis: Effects on the Status of Thyroid Hormones, Homocystein, Serum Lipids and Lipoproteins

Bovine Theileriosis: Effects on the Status of Thyroid Hormones, Homocystein, Serum Lipids and Lipoproteins

Correlations Among the Level of Homocysteine, Antioxidant Enzymes, Antioxidant Vitamins and Lipid Peroxidation of Erythrocytes in Malignant Ovine Theileriosis

Clinical and Haematobiochemical Evaluation of Pneumonia in Calves with Special Reference to Oxidant/Antioxidant Indices

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