Alterations of Circulating Biomarkers During Late Term Pregnancy Complications in the Horse Part II: Steroid Hormones and Alpha-Fetoprotein

Fedorka, Carleigh E.; Ball, Barry A.; Wynn, Michelle A.A.; McCormick, Meghan; Scoggin, Kirsten E.; Esteller-Vico, A.; Curry, Thomas E.; Kennedy, Laura; Squires, E.L.; Troedsson, Mats H.T.

doi:10.1016/j.jevs.2021.103395

Cited by 5 publications

(3 citation statements)

References 39 publications

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“…It is possible that if more frequent sampling were used, we could have observed differences. In addition, it is possible that placentitis may alter AFP concentrations more profoundly than other high-risk conditions [29]. The hypothesis of the present study that AFP is higher in mares with high-risk pregnancies has not been confirmed.…”

Section: Discussioncontrasting

confidence: 64%

“…Concentrations of AFP did not change in plasma of mares with high-risk pregnancies herein. A previous study demonstrated that AFP increased in plasma of mares with experimentally induced ascending placentitis [15,28] and another field study demonstrated that AFP increased in plasma of mares with ascending and focal mucoid placentitis [29]. The lack of change in AFP concentration in the present study could be due to an heterogenous population of mares included or because the plasma sampling was too spread out, not allowing us to detect differences between groups.…”

Section: Discussioncontrasting

confidence: 61%

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High-Risk Pregnancy Is Associated With Increased Alpha-Fetoprotein Concentrations in the Amniotic Fluid and Foal Plasma

Lanci

Mariella

Ellero

et al. 2022

Journal of Equine Veterinary Science

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Section: Discussioncontrasting

confidence: 64%

Section: Discussioncontrasting

confidence: 61%

High-Risk Pregnancy Is Associated With Increased Alpha-Fetoprotein Concentrations in the Amniotic Fluid and Foal Plasma

Lanci

Mariella

Ellero

et al. 2022

Journal of Equine Veterinary Science

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“…In the context of asymptomatic first- and second-trimester pregnancies (at 11–13, 15–20, and 24–28 weeks), previous reports have shown that serum AFP concentrations are significantly elevated in women who subsequently develop spontaneous and medically indicated PTB compared with those who deliver at term 41 – 43 . In the context of experimentally induced ascending placentitis, animal experiments using horses demonstrated that AFP concentrations are significantly elevated in the blood of the ascending placentitis group compared with controls 44 , 45 . However, to our knowledge, no data in humans are currently available concerning altered AFP expression in the maternal plasma associated with MIAC, IAI, or SPTB in the PTL setting.…”

Section: Discussionmentioning

confidence: 99%

Identification and characterization of plasma proteins associated with intra-amniotic inflammation and/or infection in women with preterm labor

Cho,

Lee,

Park

et al. 2024

Sci Rep

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This study aimed to identify plasma proteins that could serve as potential biomarkers for microbial invasion of the amniotic cavity (MIAC) or intra-amniotic inflammation (IAI) in women with preterm labor (PTL). A retrospective cohort comprised singleton pregnant women with PTL (24–34 weeks) who underwent amniocentesis. Pooled plasma samples were analyzed by label-free liquid chromatography-tandem mass spectrometry for proteome profiling in a nested case–control study (concomitant MIAC/IAI cases vs. non-MIAC/IAI controls [n = 10 per group]). Eight target proteins associated with MIAC/IAI were further verified by immunoassays in a large cohort (n = 230). Shotgun proteomic analysis revealed 133 differentially expressed proteins (fold change > 1.5, P < 0.05) in the plasma of MIAC/IAI cases. Further quantification confirmed that the levels of AFP were higher and those of kallistatin and TGFBI were lower in the plasma of women with MIAC and that the levels of kallistatin and TGFBI were lower in the plasma of women with IAI than in those without these conditions. The area under the curves of plasma AFP, kallistatin, and TGFBI ranged within 0.67–0.81 with respect to each endpoint. In summary, plasma AFP, kallistatin, and TGFBI may represent valuable non-invasive biomarkers for predicting MIAC or IAI in women with PTL.

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Update on diagnosing and treating ascending placentitis in horses

Crabtree

2023

In Practice

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Background: Ascending placentitis is a relatively uncommon condition in horses; however, it can have significant consequences on the health of a pregnancy. If undiagnosed the condition commonly results in abortion which may come with a significant emotional and economic burden to horse breeders.Aim of the article: This article focuses on the diagnosis and treatment of ascending bacterial placentitis, bringing readers up to date with recent advances in the pathophysiology, diagnosis and treatment of clinical cases.

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Alterations of Circulating Biomarkers During Late Term Pregnancy Complications in the Horse Part II: Steroid Hormones and Alpha-Fetoprotein

Cited by 5 publications

References 39 publications

High-Risk Pregnancy Is Associated With Increased Alpha-Fetoprotein Concentrations in the Amniotic Fluid and Foal Plasma

High-Risk Pregnancy Is Associated With Increased Alpha-Fetoprotein Concentrations in the Amniotic Fluid and Foal Plasma

Identification and characterization of plasma proteins associated with intra-amniotic inflammation and/or infection in women with preterm labor

Update on diagnosing and treating ascending placentitis in horses

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