Alterations of Cholesterol Biosynthesis in Liver Cell Fractions from Rats in Various Experimental Conditions

Cholesterol Inhibition of Pentacyclic Triterpenoid Biosynthesis in Tetrahymena pyriformis*†

“…Further, inhibition of squalene conversion to the pentacyclic alcohols by cholesterol has been established. lic triterpene bio'synthesis was a feedback mechanism similar to that noted by a number of investigators (4,5,20,21,36) in mammalian tissues. To answer this question, further knowledge about tetrahymanol biosynthesis was required in order to determine the site or sites of the inhibition induced by the addition of cholesterol to the growth medium.…”