Abstract:Summary: Persistent hyperglycemia in diabetes mellitus (DM) leads to progression of secondary complications, such as neuropathy, nephropathy and retinopathy, which cause irreversible damage once initiated. During states of hyperglycemia, the polyol pathway has increased activity. As a result of the increased polyol pathway activity and the overutilization of NADPH by the enzyme aldose reductase (AR), a number of other homeostatic mechanisms are compromised. In view of the complex metabolic changes induced by h… Show more
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