Alterations in XRCC1 gene profile in pathogenesis of oral cavity cancer: A population-based study from Kamrup Urban District of Assam, India

Borkotoky, Raktim; Malakar, Biswajit; Saikia, Anjan; Mukherjee, Shambhu N.; Bose, Sujoy

doi:10.1016/j.currproblcancer.2019.03.003

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…Another study compared proteomic profiles in saliva samples from healthy donors and tamol chewers, which tend to form ulcers in the oral cavity ( Kumar et al, 2021 ) predisposing to develop oral cancer ( Phukan et al, 2001 ; Borkotoky et al, 2020 ). ANXA4 expression levels showed a 20.22% increase in tamol chewers versus healthy controls, which led to propose ANXA4 as a population screening marker for the early detection of OSCC in tamol consumers (lepcha et al, 2021).…”

Section: Annexin A4mentioning

confidence: 99%

Pathobiological functions and clinical implications of annexin dysregulation in human cancers

Prieto-Fernández

Menéndez

Otero-Rosales

et al. 2022

Front. Cell Dev. Biol.

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Annexins are an extensive superfamily of structurally related calcium- and phospholipid-binding proteins, largely conserved and widely distributed among species. Twelve human annexins have been identified, referred to as Annexin A1-13 (A12 remains as of yet unassigned), whose genes are spread throughout the genome on eight different chromosomes. According to their distinct tissue distribution and subcellular localization, annexins have been functionally implicated in a variety of biological processes relevant to both physiological and pathological conditions. Dysregulation of annexin expression patterns and functions has been revealed as a common feature in multiple cancers, thereby emerging as potential biomarkers and molecular targets for clinical application. Nevertheless, translation of this knowledge to the clinic requires in-depth functional and mechanistic characterization of dysregulated annexins for each individual cancer type, since each protein exhibits varying expression levels and phenotypic specificity depending on the tumor types. This review specifically and thoroughly examines the current knowledge on annexin dysfunctions in carcinogenesis. Hence, available data on expression levels, mechanism of action and pathophysiological effects of Annexin A1-13 among different cancers will be dissected, also further discussing future perspectives for potential applications as biomarkers for early diagnosis, prognosis and molecular-targeted therapies. Special attention is devoted to head and neck cancers (HNC), a complex and heterogeneous group of aggressive malignancies, often lately diagnosed, with high mortality, and scarce therapeutic options.

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Section: Annexin A4mentioning

confidence: 99%

Pathobiological functions and clinical implications of annexin dysregulation in human cancers

Prieto-Fernández

Menéndez

Otero-Rosales

et al. 2022

Front. Cell Dev. Biol.

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“…Comprises strong chemical compound in slaked lime which further forms scars or ulcers by burns the soft tissue in the oral cavity. Which can further be a main contributing factor for developing oral cancer (Phukan et al, 2001;Borkotoky et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Besides diagnosis based on tissue, and body fluids like saliva and blood are the extensively studied samples that may comprise consistent biomarkers for cancer analysis. The saliva sample is an enlightening body fluid containing a range of analytes such as protein (Singh et al,2020;Roi et al, 2020), mRNA (Oh et al, 2020), antioxidant profile (Lepcha et al, 2019), and DNA (Lepcha et al, 2021;Borkotoky et al, 2020) which can be used as diagnostic and prognostic markers for clinical and therapeutic applications. Several studies have investigated the use of salivary proteins as a potential diagnostic marker for oral cancer.…”

Section: Introductionmentioning

confidence: 99%

Protein Profile of Human Saliva as a Predictive and Prognostic Tool for OSCC in Tamol Chewer’s Population in Assam

Lepcha

Sarma

Kataki

et al. 2021

Asian Pac J Cancer Prev

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Objective: To identify potential proteomic salivary biomarker in tamol chewers and comparing it to healthy and Oral squamous cell carcinoma cases. Methods: A total of fifty unstimulated saliva samples were collected from the healthy volunteers, tamol chewers (without tobacco), and OSCC patients referred to North-East cancer Hospital, Jorabat, Assam, India. The 2-D gel analysis and western blotting were performed to analyze protein profiling. Results: The identified proteins were serum albumin, HSP (Heat shock protein) 27, gamma actin, SCC (Squamous cell carcinoma) 1, and Annexin A4. All the proteins were associated with OSCC development when their values were compared with those of normal healthy subjects. HSP27 was subjected to further validation using western blotting methods. An increase of 18.39% (Serum Albumin), 15.04% (gamma actin), 14.01% (SSC 1), and 20.22% (ANX4) were observed in Tamol chewers when compared with healthy control subjects. Conclusion: Our results revealed that the identified salivary proteins have a positive association with OSCC development. Profiling of these saliva proteomes especially HSP (Heat shock protein) 27 as a potential biomarker for OSCC detection in the high-risk population is recommended.

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The XRCC1 Arg194Trp polymorphism was associated with the risk of head and neck squamous cell carcinoma development: Results from a systematic review and meta‐analysis

2022

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Background: The X-ray repair cross complementing group 1 (XRCC1) is a DNA repair gene. Various studies have examined the association between XRCC1 Arg194Trp polymorphism and head and neck squamous cell carcinoma (HNSCC) susceptibility with contradictory results. So, this systematic review and meta-analysis aimed to assess whether variants of this polymorphism increase the HNSCC risk or not.Recent findings: Thirty three studies consisting of 14282 subjects (6012 cases and 8270 controls) were included in this meta-analysis. Variants of XRCC1 Arg194Trp polymorphism were associated with increased HNSCC risk and the associations were significant based on heterozygous and dominant models (heterozygous model:

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Alterations in XRCC1 gene profile in pathogenesis of oral cavity cancer: A population-based study from Kamrup Urban District of Assam, India

Cited by 6 publications

References 20 publications

Pathobiological functions and clinical implications of annexin dysregulation in human cancers

Pathobiological functions and clinical implications of annexin dysregulation in human cancers

Protein Profile of Human Saliva as a Predictive and Prognostic Tool for OSCC in Tamol Chewer’s Population in Assam

The XRCC1 Arg194Trp polymorphism was associated with the risk of head and neck squamous cell carcinoma development: Results from a systematic review and meta‐analysis

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