Alterations in white matter microstructures and cognitive dysfunctions in benign childhood epilepsy with centrotemporal spikes

Kim, S. E.; Lee, J. H.; Chung, Hae Sun; Lim, Soo Mee; Lee, H. W.

doi:10.1111/ene.12301

Cited by 54 publications

(47 citation statements)

References 32 publications

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“…The total number of people with epilepsy and controls was 1027 and 1122, respectively. Sixteen voxel-based studies were included, with 312 patients and 500 controls (Amarreh et al, 2014, Bonilha et al, 2015, Concha et al, 2012, Focke et al, 2014, Keller et al, 2013, Kim et al, 2012, Kim et al, 2014, Li et al, 2010, Liu et al, 2015, O'Muircheartaigh et al, 2011, Peng et al, 2014, Riley et al, 2010, Rugg-Gunn et al, 2001, Wang et al, 2011, Whelan et al, 2015, Yang et al, 2012). One of these studies was also included in the meta-analysis (Li et al, 2010).…”

Section: Resultsmentioning

confidence: 99%

White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis

Slinger

Sinke

Braun

et al. 2016

NeuroImage: Clinical

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ObjectiveSince the introduction of diffusion tensor imaging, white matter abnormalities in epilepsy have been studied extensively. However, the affected areas reported, the extent of abnormalities and the association with relevant clinical parameters are highly variable. We aimed to obtain a more consistent estimate of white matter abnormalities and their association with clinical parameters in different epilepsy types.MethodsWe systematically searched for differences in white matter fractional anisotropy and mean diffusivity, at regional and voxel level, between people with epilepsy and healthy controls. Meta-analyses were used to quantify the directionality and extent of these differences. Correlations between white matter differences and age of epilepsy onset, duration of epilepsy and sex were assessed with meta-regressions.ResultsForty-two studies, with 1027 people with epilepsy and 1122 controls, were included with regional data. Sixteen voxel-based studies were also included. People with temporal or frontal lobe epilepsy had significantly decreased fractional anisotropy (Δ –0.021, 95% confidence interval –0.026 to –0.016) and increased mean diffusivity (Δ0.026 × 10–3 mm2/s, 0.012 to 0.039) in the commissural, association and projection white matter fibers. White matter was much less affected in generalized epilepsy. White matter changes in people with focal epilepsy correlated with age at onset, epilepsy duration and sex.SignificanceThis study provides a better estimation of white matter changes in different epilepsies. Effects are particularly found in people with focal epilepsy. Correlations with the duration of focal epilepsy support the hypothesis that these changes are, at least partly, a consequence of seizures and may warrant early surgery. Future studies need to guarantee adequate group sizes, as white matter differences in epilepsy are small.

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Section: Resultsmentioning

confidence: 99%

White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis

Slinger

Sinke

Braun

et al. 2016

NeuroImage: Clinical

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“…For example, the left insula and bilateral middle/superior frontal gyrus have been implicated in language function in typically developing children and children with BECTS . The essential role of prefrontal cortex in attention and executive function is well established, and executive function deficit, a common comorbidity in BECTS, has been related to abnormal frontooccipital white matter connectivity . We note that these structural–functional associations remain tentative and future studies are needed to target this question.…”

Section: Discussionmentioning

confidence: 99%

Cognition and brain development in children with benign epilepsy with centrotemporal spikes

et al. 2015

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Objective Benign epilepsy with centrotemporal spikes (BECTS), the most common focal childhood epilepsy, is associated with subtle abnormalities in cognition and possible developmental alterations in brain structure when compared to healthy participants as indicated by previous cross-sectional studies. To examine the natural history of BECTS, we investigated cognition, cortical thickness, and subcortical volumes in children with new/recent onset BECTS and healthy controls (HC). Methods Participants were 8–15 years of age, including 24 children with new onset BECTS and 41 age- and gender-matched HC. At baseline and two years later, all participants completed a cognitive assessment and a subset (13 BECTS, 24 HC) underwent T1 volumetric MRI scans focusing on cortical thickness and subcortical volumes. Results Baseline cognitive abnormalities associated with BECTS (object naming, verbal learning, arithmetic computation, psychomotor speed/dexterity) persisted over two years, with the rate of cognitive development paralleling that of HC. Baseline neuroimaging revealed thinner cortex in BECTS compared to controls in frontal, temporal, and occipital regions. Longitudinally, HC showed widespread cortical thinning in both hemispheres, while BECTS participants showed sparse regions of both cortical thinning and thickening. Analyses of subcortical volumes showed larger left and right putamens persisting over two years in BECTS compared to HC. Significance Cognitive and structural brain abnormalities associated with BECTS are present at onset and persist (cognition) and/or evolve (brain structure) over time. Atypical maturation of cortical thickness antecedent to BECTS onset results in early-identified abnormalities that further continue to abnormally develop over time. However, cognition appears more resistant to further change over time compared to anatomical development.

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“…Принципиально важно то, что более низкий показатель IQ (и особенно -вербального интеллекта) отмечался в группе больных РЭ, у которых на МРТ выявлялись нарушения структуры белого вещества головного мозга. Сделан вывод о том, что даже небольшие структурные изменения в белом веществе (более значимо -левого полушария) могут приводить к когнитивным нарушениям у больных РЭ [67].…”

Section: Ch I Ld Neurology R U S S I a N J O U R N A L O Funclassified

Benign epileptiform discharges of childhood and associated conditions

Мухин¹

2018

Rus. ž. det. nevrol.

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This article provides a detailed description of benign epileptiform discharges of childhood (BEDC) as one of electroencephalography patterns in children. We emphasize that BEDC are not specific for both idiopathic (genetic) focal epilepsy and epilepsy in general. BEDC can be observed in a number of various disorders and also in neurologically healthy children. We developed a detailed classification of BEDC-associated states that are divided into 3 groups: neurologically healthy children, children with various forms of epilepsy, and patients with various neurological disorders without epilepsy. We found that there are 2 main factors responsible for BEDC in electroencephalogram: genetic predisposition and white matter lesions, usually occurring during the antenatal or perinatal period. BEDC should be considered rather a manifestation of congenital abnormalities in brain maturation than a marker of epilepsy. We also discuss the need for therapy in patients with BEDC-associated states.

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Alterations in white matter microstructures and cognitive dysfunctions in benign childhood epilepsy with centrotemporal spikes

Abstract: White matter microstructural changes predominantly in the left hemisphere might contribute to their cognitive abnormalities especially verbal IQ in BECTS patients.

Cited by 54 publications

References 32 publications

White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis

White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis

Cognition and brain development in children with benign epilepsy with centrotemporal spikes

Benign epileptiform discharges of childhood and associated conditions

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