Alterations in Vitamin A and E Levels in Liver and Testis of Wild Ungulates from a Lead Mining Area

Rodríguez-Estival, Jaime; Taggart, Mark A.; Mateo, Rafael

doi:10.1007/s00244-010-9597-z

Cited by 30 publications

(11 citation statements)

References 39 publications

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“…Plasma uric acid decreased in mallards exposed to Pb contaminated sediment . The effect of Pb exposure on plasma vitamin A has not been described previously; however, other environmental pollutants cause severe disturbances in vitamin A metabolism (Zile, 1992;Rolland, 2000;Rodríguez-Estival et al, 2011).…”

Section: Oxidative Stressmentioning

confidence: 94%

Effects of lead exposure on oxidative stress biomarkers and plasma biochemistry in waterbirds in the field

Martínez-Haro

Green

Mateo

2011

Environmental Research

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114

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and in all common pochards (Aythya ferina) (n ¼ 4), but common coots (Fulica atra) (n ¼ 37) and moorhens (Gallinula chloropus) (n ¼ 12) were all o 20 mg/dl. ALAD ratio in mallards and coots decreased with PbB levels 4 6 mg/dl. In mallards, an inhibition of glutathione peroxidase (GPx) and an increased level of oxidized glutathione (oxGSH) in red blood cells (RBC) were associated with PbB levels 4 20 mg/ dl. In coots, PbB levels were negatively related to vitamin A and carotenoid levels in plasma, and total glutathione in RBCs; and positively related with higher superoxide dismutase and GPx activities and % oxGSH in RBCs. Overall, the results indicate that previously assumed background levels of PbB for birds need to be revised.

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Section: Oxidative Stressmentioning

confidence: 94%

Effects of lead exposure on oxidative stress biomarkers and plasma biochemistry in waterbirds in the field

Martínez-Haro

Green

Mateo

2011

Environmental Research

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114

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“…Previous studies concerned with the effect of lead and cadmium on reproductive function in males focused on passive changes induced by exposure to heavy metals on testis (histology and function in animals) [18–20]or semen parameters (in humans and animals) [17, 21–25]with fewer studies on the effect of these metals on pregnancy rate [26]. …”

Section: Discussionmentioning

confidence: 99%

Correlation between seminal lead and cadmium and seminal parameters in idiopathic oligoasthenozoospermic males

Taha¹,

Sayed

Ghandour³

et al. 2013

cejurol1/2013

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IntroductionThe exact causes of the decline in semen quality are not yet known, environmental factors have been considered to play an important role. Lead (Pb) and Cadmium (Cd) are two of the well-known reproductive toxicants to which humans are exposed occupationally and environmentally and can lead to negative effects on the testicular functions. The aim of this study was to evaluate lead and cadmium levels in seminal plasma of men with idiopathic oligoasthenozoospermia in comparison to fertile healthy controls and to correlate these levels with conventional semen parameters, sperm hypo-osmotic swelling (HOS) percentage, sperm DNA fragmentation percentage, and semen reactive oxygen species (ROS) levels.Material and MethodsThirty infertile male patients with idiopathic oligo and/or asthenozoospermia and thirty healthy fertile men, which was the control group, were included in the study. Lead and cadmium levels in seminal plasma, semen parameters, sperm HOS, sperm DNA fragmentation percentage and semen ROS assay were measured in all subjects.ResultsThere was a significant increase in seminal lead and cadmium levels among infertile males in comparison to controls. There were significant negative correlations between seminal lead and cadmium levels on one hand and certain semen parameters especially progressive sperm motility and vitality (HOS). Importantly, significant positive correlations were noted between seminal lead and cadmium levels on one hand and sperm DNA fragmentation percentage and semen ROS level in infertile men and controls on the other hand.ConclusionsThus, men with idiopathic male infertility had higher levels of lead and cadmium in their semen which correlated with impairment of sperm motility and vitality percentages and more importantly with higher sperm DNA fragmentation% and semen ROS level.

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“…1). The predominant landscape is Mediterranean forest [17], although the soils affected by mines and dumps remain unvegetated or sparsely vegetated. Control sites were located in the northern part of the province of Ciudad Real, where natural habitats are similar to those found in the mining area but are not known to be rich in mineralized zones with high metal concentrations in soils, plants, or sediments [18].…”

Section: Study Areamentioning

confidence: 99%

“…Statistical analyses were developed after testing the normality and the homogeneity of variances for each variable and logtransforming those variables that did not display a normal distribution [16,17]. Generalized linear models (GLMs) were used to test for differences in each variable between the control and mining areas, including the area and gender as factors.…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Moreover, assessing the effects of Pb exposure on the immune response of wildlife becomes more relevant when it concerns big game species such as red deer (Cervus elaphus) and wild boar (Sus scrofa), because both species are actors in the epidemiology of chronic infectious diseases (e.g., tuberculosis) shared with livestock [15]. Previous studies have found that Pb alters the cellular redox state in the liver of red deer and wild boar exposed to mining pollution [11,16] and that Pb-mediated oxidative stress might be involved in changes of sperm quality detected in red deer from a mining area [12,17]. Studies also have found changes in copper (Cu) and selenium (Se) homeostasis in tissues of wild ungulates [11,12].…”

Section: Introductionmentioning

confidence: 99%

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Expression of immunoregulatory genes and its relationship to lead exposure and lead‐mediated oxidative stress in wild ungulates from an abandoned mining area

Rodríguez-Estival

Lastra

Ortiz‐Santaliestra

et al. 2013

Enviro Toxic and Chemistry

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Abstract-Lead (Pb) is a highly toxic metal that can induce oxidative stress and affect the immune system by modifying the expression of immunomodulator-related genes. The aim of the present study was to investigate the association between Pb exposure and the transcriptional profiles of some cytokines, as well as the relationship between Pb exposure and changes in oxidative stress biomarkers observed in the spleen of wild ungulates exposed to mining pollution. Red deer and wild boar from the mining area studied had higher spleen, liver, and bone Pb levels than controls, indicating a chronic exposure to Pb pollution. Such exposure caused a depletion of spleen glutathione levels in both species and disrupted the activity of antioxidant enzymes, suggesting the generation of oxidative stress conditions. Deer from the mining area also showed an induced T-helper (T h )-dependent immune response toward the T h 2 pathway, whereas boar from the mining area showed a cytokine profile suggesting an inclination of the immune response toward the T h 1 pathway. These results indicate that environmental exposure to Pb may alter immune responses in wild ungulates exposed to mining pollution. However, evidence of direct relationships between Pb-mediated oxidative stress and the changes detected in immune responses were not found. Further research is needed to evaluate the immunotoxic potential of Pb pollution, also considering the prevalence of chronic infectious diseases in wildlife in environments affected by mining activities. Environ. Toxicol. Chem. 2013;32:876-883.

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Alterations in Vitamin A and E Levels in Liver and Testis of Wild Ungulates from a Lead Mining Area

Cited by 30 publications

References 39 publications

Effects of lead exposure on oxidative stress biomarkers and plasma biochemistry in waterbirds in the field

Effects of lead exposure on oxidative stress biomarkers and plasma biochemistry in waterbirds in the field

Correlation between seminal lead and cadmium and seminal parameters in idiopathic oligoasthenozoospermic males

Expression of immunoregulatory genes and its relationship to lead exposure and lead‐mediated oxidative stress in wild ungulates from an abandoned mining area

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